Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 54293559

GI number: 54293559

Start: 658317

End: 659522

Strand: Direct

Name: tyrS [H]

Synonym: lpl0611

Alternate gene names: 54293559

Gene position: 658317-659522 (Clockwise)

Preceding gene: 54293557

Following gene: 54293560

Centisome position: 19.68

GC content: 37.31

Gene sequence:

>1206_bases
ATGATAGTTCAAGATTCAGTTTGTTCCGAATTAATGCGGGGGTGTGAGGAAATTCTTCCTGTACCTGAGTTGGAGAAGAA
ATTACAAAAAGGTATCCCATTGAAAATAAAGGCAGGTTTTGATCCAACAGCGCCAGATCTTCATTTGGGACATACTGTAC
TGCTTAATAAATTGAGGCAGTTTCAGCAATTTGGTCATGAGGTTATTTTTTTGATTGGTGATTTCACAGCCATGATTGGT
GATCCAACTGGAAAAAATGTAACCCGAATGCCATTGAGTCAGGAAACGGTTCTGGAAAATGCAAAAACCTATCAACACCA
GGTATTTAAAATTCTTGACCCTGATAAGACTACGGTGGCTTTCAATTCACAATGGCTTAATAAATTTAATGCGGTTGATT
TGATTCGACTGGCTGCAACACATACTGTGGCAAGAATGCTGGAACGAGATGATTTCAATAAACGTTATACTACAGGACAG
CCTATCGCAATTCACGAATTTTTGTACCCGCTGTTACAAGGTTATGATTCAGTGGCATTAAAAGCTGACGTTGAACTTGG
CGGCACTGATCAGAAATTTAATTTATTGATGGGTAGAGAATTACAGAAGCATTATGGCTTTGAGCCTCAAGTTGTCATGA
TGACACCATTAATAGAGGGTTTGGATGGTGTAAAGAAAATGTCGAAATCCCTTGATAATTACATTGGGATCAATGAAACA
TCTGAGCAAATGTTCGGAAAAATCATGTCAGTTTCTGATGAGTTAATGTGGCGATATATTGATTTATTAAGCTTTAAAAC
AGGCAAGGAAATACAACAATTAAAACAATCTGTATTAGAAGGGAAAAATCCCAGAGATGTTAAGATTGATTTTGCCAAAG
AAATTGTTGCGCGATTTCATGATCAAACTCAGGCTGAATTCGCTCATAACAAGTTTATTGAACGATTTCAAAAAGGAAAT
ATTCCTGAAGACTTGGAAGAACTGTCGTTAGTTATTGCAGAGCCGATAGCTTTAGCACAATTATTAAAGCAAATTGATTT
GACAGCCAGCACATCAGAGTCTATAAGAATGGTGAAACAAGGGGCTGTTAAAGTGGATGGGGATAAAATTTCAGATCCTT
CCCTAAAATTACCTATTGGCAAGTCTTATATTATTCAAGTTGGAAAACGTCGAATTGCCAAGCTGAGCATTCAACAAGCA
CACTGA

Upstream 100 bases:

>100_bases
TATCTCAAAATGTATCATTTGGTATAGCAGGAAATTGCTAACCGGGCTAAGATACTCGCTGCGAGAAGATAGGTCAATCA
TTTATATGGGTTTTAATGAC

Downstream 100 bases:

>100_bases
GATAATTTTTTAAAAAAAATTAAAAAAGTATTTGACAGAGTTGTTGAAATGAGTAGAATACGCCCTACGCCACGAGGGCG
GGTTCATTAAGAAGAGAGAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQFQQFGHEVIFLIGDFTAMIG
DPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVAFNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQ
PIAIHEFLYPLLQGYDSVALKADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINET
SEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFHDQTQAEFAHNKFIERFQKGN
IPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQGAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQA
H

Sequences:

>Translated_401_residues
MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQFQQFGHEVIFLIGDFTAMIG
DPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVAFNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQ
PIAIHEFLYPLLQGYDSVALKADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINET
SEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFHDQTQAEFAHNKFIERFQKGN
IPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQGAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQA
H
>Mature_401_residues
MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQFQQFGHEVIFLIGDFTAMIG
DPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVAFNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQ
PIAIHEFLYPLLQGYDSVALKADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINET
SEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFHDQTQAEFAHNKFIERFQKGN
IPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQGAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQA
H

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=411, Percent_Identity=26.5206812652068, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1787925, Length=375, Percent_Identity=30.4, Blast_Score=131, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI25145802, Length=212, Percent_Identity=32.5471698113208, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325160, Length=437, Percent_Identity=24.4851258581236, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130383, Length=403, Percent_Identity=24.0694789081886, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45352; Mature: 45352

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50889 S4 ; PS00435 PEROXIDASE_1 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQ
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
FQQFGHEVIFLIGDFTAMIGDPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVA
HHHCCHHEEEEEHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
FNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQPIAIHEFLYPLLQGYDSVAL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
KADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINET
EEECEECCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCH
SEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
DQTQAEFAHNKFIERFQKGNIPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQAH
CCEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQ
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
FQQFGHEVIFLIGDFTAMIGDPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVA
HHHCCHHEEEEEHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
FNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQPIAIHEFLYPLLQGYDSVAL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
KADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINET
EEECEECCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCH
SEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
DQTQAEFAHNKFIERFQKGNIPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQAH
CCEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA