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The map label for this gene is murA1

Identifier: 54293560

GI number: 54293560

Start: 665033

End: 666556

Strand: Direct

Name: murA1

Synonym: lpl0612

Alternate gene names: 54293560

Gene position: 665033-666556 (Clockwise)

Preceding gene: 54293559

Following gene: 54293564

Centisome position: 19.88

GC content: 39.37

Gene sequence:

>1524_bases
ATGTTAAGCAAATATGAGCTAATTAAACCTGACATAGGATCCAGTCACGGCAATATCACAAAAGTGTATGAAATAGTCGG
CGGCAAACCGCTCAGAGGGCAAGTCAAAGTAAGCGGGTCTAAAAATGCTGCTCTGCCTGTACTGGCAGCGAGTTTATTAT
GCAAAGAGCCGCTGCAGTTAACCAATTTACCGAAAATATTAGATGTTACCAATATGATTCAATGCATGGAAGCATTAGGT
AAAAGATTTGAATTTATCAATACTAACACGATTAAAATTGGCAATAGAGAAATGGATACACTGACTATTCCAAAGGAGGC
AGCCAGACAAATTCGTGCTTCAATTATTTTATTAGGCCCTTTGGTTGCGCAGTATCCAAAGGTGATATTGCCATTACCAG
GTGGATGCTCTATTGGGAAACGTCCCATTGATTTGCACATCAGTGCGCTTAATGCGTTGGGTGTAGATATTGTTGAGCTA
CCAGATTGTTTAGTATGTTCTCGCCGTTATGCTCGGCTTCAAGGAAATACTATTAACTTTTCCATCAAGACTGTGACTGG
AACAGAAAATGCGATGATGGCGGCTGTATTGGCAGAAGGAACAACTATTATAAATAATGCTGCAATGGAACCCGAGATAG
TTGATTTGGCTAATTTTTTAAATAGGCTTGGAGCAAAAATTAATGGGGGGGGTAGCGACAGAATCACAATTTCCGGTGTA
GATAAATTAAATTCTTGTGGAAGTTATTCCATCATGGCAGATAGAATCGAGGCTGGTACTTATTTAGTAGCAGCAGCGAT
GACTCGCGGTTCTATTTCCGTTAAAGGAGTCAATCCGGATTATCTGGTTGCAGTTTTGAGCGAATTAAAATGTGCAGGTG
CAAAAATTACCTGTGATTCTGACTCAATCCAGCTTGATATGGGAGAAGAGTATGGTGAATCGTTAAATATAACCACAAAA
CCCTATCCAGGCTTTCCAACAGATCTGCAATCTCTCTTTTTAAGTCTGACTTGTGTTTTAAGGGGTAACTCTTATTTGTG
TGAGACTCTATTTGAAGATCGTTTTCAAATAGTCCAAGAGCTTAAAAAAATGGGAGCCAATATTTCTTTAAAGGATAACA
CTGCCCACATAAAGGGTGTTTCAAGATTAAGGGGTTCTCAAGTCAATGCTACTGATTTACGCTCAGGTGCCGCTTTAGTA
TGTGCCAGTTTGGCAGCGGAGGGTATCACGCAGATTTTTGCCATAGAGCATATAGAGCGCGGTTATGAAGATTTAATATT
AAAATTAAAAGCACTTGGCGCCAATATTAAATTAATTGAGAATACCCATGTAACAAGCACGGAATTATCTGACAGTCATT
TCAAAGAGGCGACTAGTAGTGAAACTCGAATACAACGAGCATCGTTGATTGAAACCATAGTAACACCATCTATAACAACA
TTTGGACAGTTTAAAAGAGTACCTACAGGAGAAGTGACGGAATTGGAAAAACAGCAGACACCTTATCTGCATCACATTAT
GTAA

Upstream 100 bases:

>100_bases
GTTATGGTTTGGAAGTATAGTGCTTTTATATGATAAAGCAGTATCAATAAGTAACAGACAGAAAGAGCTATAAGTATTTC
AAGATTAAGATTGGTGGTTA

Downstream 100 bases:

>100_bases
GGTATCTATCCTTTAATCTTATATAATGCCCGGCAGAATATTCAATTTGCTCTATCTCTTTTGCAGTTAATTTTCTGACG
GCTTGAACTGGGCTGCCCAA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MLSKYELIKPDIGSSHGNITKVYEIVGGKPLRGQVKVSGSKNAALPVLAASLLCKEPLQLTNLPKILDVTNMIQCMEALG
KRFEFINTNTIKIGNREMDTLTIPKEAARQIRASIILLGPLVAQYPKVILPLPGGCSIGKRPIDLHISALNALGVDIVEL
PDCLVCSRRYARLQGNTINFSIKTVTGTENAMMAAVLAEGTTIINNAAMEPEIVDLANFLNRLGAKINGGGSDRITISGV
DKLNSCGSYSIMADRIEAGTYLVAAAMTRGSISVKGVNPDYLVAVLSELKCAGAKITCDSDSIQLDMGEEYGESLNITTK
PYPGFPTDLQSLFLSLTCVLRGNSYLCETLFEDRFQIVQELKKMGANISLKDNTAHIKGVSRLRGSQVNATDLRSGAALV
CASLAAEGITQIFAIEHIERGYEDLILKLKALGANIKLIENTHVTSTELSDSHFKEATSSETRIQRASLIETIVTPSITT
FGQFKRVPTGEVTELEKQQTPYLHHIM

Sequences:

>Translated_507_residues
MLSKYELIKPDIGSSHGNITKVYEIVGGKPLRGQVKVSGSKNAALPVLAASLLCKEPLQLTNLPKILDVTNMIQCMEALG
KRFEFINTNTIKIGNREMDTLTIPKEAARQIRASIILLGPLVAQYPKVILPLPGGCSIGKRPIDLHISALNALGVDIVEL
PDCLVCSRRYARLQGNTINFSIKTVTGTENAMMAAVLAEGTTIINNAAMEPEIVDLANFLNRLGAKINGGGSDRITISGV
DKLNSCGSYSIMADRIEAGTYLVAAAMTRGSISVKGVNPDYLVAVLSELKCAGAKITCDSDSIQLDMGEEYGESLNITTK
PYPGFPTDLQSLFLSLTCVLRGNSYLCETLFEDRFQIVQELKKMGANISLKDNTAHIKGVSRLRGSQVNATDLRSGAALV
CASLAAEGITQIFAIEHIERGYEDLILKLKALGANIKLIENTHVTSTELSDSHFKEATSSETRIQRASLIETIVTPSITT
FGQFKRVPTGEVTELEKQQTPYLHHIM
>Mature_507_residues
MLSKYELIKPDIGSSHGNITKVYEIVGGKPLRGQVKVSGSKNAALPVLAASLLCKEPLQLTNLPKILDVTNMIQCMEALG
KRFEFINTNTIKIGNREMDTLTIPKEAARQIRASIILLGPLVAQYPKVILPLPGGCSIGKRPIDLHISALNALGVDIVEL
PDCLVCSRRYARLQGNTINFSIKTVTGTENAMMAAVLAEGTTIINNAAMEPEIVDLANFLNRLGAKINGGGSDRITISGV
DKLNSCGSYSIMADRIEAGTYLVAAAMTRGSISVKGVNPDYLVAVLSELKCAGAKITCDSDSIQLDMGEEYGESLNITTK
PYPGFPTDLQSLFLSLTCVLRGNSYLCETLFEDRFQIVQELKKMGANISLKDNTAHIKGVSRLRGSQVNATDLRSGAALV
CASLAAEGITQIFAIEHIERGYEDLILKLKALGANIKLIENTHVTSTELSDSHFKEATSSETRIQRASLIETIVTPSITT
FGQFKRVPTGEVTELEKQQTPYLHHIM

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=46.88995215311, Blast_Score=364, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_LEGPL (Q5WYX3)

Other databases:

- EMBL:   CR628337
- RefSeq:   YP_125975.1
- ProteinModelPortal:   Q5WYX3
- SMR:   Q5WYX3
- STRING:   Q5WYX3
- GeneID:   3116300
- GenomeReviews:   CR628337_GR
- KEGG:   lpf:lpl0612
- NMPDR:   fig|297245.3.peg.388
- LegioList:   lpl0612
- eggNOG:   COG0766
- HOGENOM:   HBG482701
- OMA:   KNEALQI
- PhylomeDB:   Q5WYX3
- ProtClustDB:   PRK09369
- BioCyc:   LPNE297245:LPL0612-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 54854; Mature: 54854

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKYELIKPDIGSSHGNITKVYEIVGGKPLRGQVKVSGSKNAALPVLAASLLCKEPLQL
CCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHH
TNLPKILDVTNMIQCMEALGKRFEFINTNTIKIGNREMDTLTIPKEAARQIRASIILLGP
CCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEECCHHHHHHHHHHHHEEHH
LVAQYPKVILPLPGGCSIGKRPIDLHISALNALGVDIVELPDCLVCSRRYARLQGNTINF
HHHHCCCEEEECCCCCCCCCCCEEEEEEEHHHCCCCHHHCCHHHHHHHHHHHHCCCEEEE
SIKTVTGTENAMMAAVLAEGTTIINNAAMEPEIVDLANFLNRLGAKINGGGSDRITISGV
EEEEEECCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCEECCCCCCEEEEECC
DKLNSCGSYSIMADRIEAGTYLVAAAMTRGSISVKGVNPDYLVAVLSELKCAGAKITCDS
HHCCCCCCCEEEHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCEEEECC
DSIQLDMGEEYGESLNITTKPYPGFPTDLQSLFLSLTCVLRGNSYLCETLFEDRFQIVQE
CCEEEECCHHCCCCCCEECCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
LKKMGANISLKDNTAHIKGVSRLRGSQVNATDLRSGAALVCASLAAEGITQIFAIEHIER
HHHCCCCEEECCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
GYEDLILKLKALGANIKLIENTHVTSTELSDSHFKEATSSETRIQRASLIETIVTPSITT
CHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
FGQFKRVPTGEVTELEKQQTPYLHHIM
CHHHCCCCCCCHHHHHHHCCCCHHHCC
>Mature Secondary Structure
MLSKYELIKPDIGSSHGNITKVYEIVGGKPLRGQVKVSGSKNAALPVLAASLLCKEPLQL
CCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHH
TNLPKILDVTNMIQCMEALGKRFEFINTNTIKIGNREMDTLTIPKEAARQIRASIILLGP
CCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEECCHHHHHHHHHHHHEEHH
LVAQYPKVILPLPGGCSIGKRPIDLHISALNALGVDIVELPDCLVCSRRYARLQGNTINF
HHHHCCCEEEECCCCCCCCCCCEEEEEEEHHHCCCCHHHCCHHHHHHHHHHHHCCCEEEE
SIKTVTGTENAMMAAVLAEGTTIINNAAMEPEIVDLANFLNRLGAKINGGGSDRITISGV
EEEEEECCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCEECCCCCCEEEEECC
DKLNSCGSYSIMADRIEAGTYLVAAAMTRGSISVKGVNPDYLVAVLSELKCAGAKITCDS
HHCCCCCCCEEEHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCEEEECC
DSIQLDMGEEYGESLNITTKPYPGFPTDLQSLFLSLTCVLRGNSYLCETLFEDRFQIVQE
CCEEEECCHHCCCCCCEECCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
LKKMGANISLKDNTAHIKGVSRLRGSQVNATDLRSGAALVCASLAAEGITQIFAIEHIER
HHHCCCCEEECCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
GYEDLILKLKALGANIKLIENTHVTSTELSDSHFKEATSSETRIQRASLIETIVTPSITT
CHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
FGQFKRVPTGEVTELEKQQTPYLHHIM
CHHHCCCCCCCHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA