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The map label for this gene is lpxD [H]

Identifier: 54293498

GI number: 54293498

Start: 596534

End: 597553

Strand: Direct

Name: lpxD [H]

Synonym: lpl0547

Alternate gene names: 54293498

Gene position: 596534-597553 (Clockwise)

Preceding gene: 54293497

Following gene: 54293499

Centisome position: 17.83

GC content: 41.96

Gene sequence:

>1020_bases
TTGCTAACCTTAGAGGAACTGGCAAACTATTTAAATGGCGTCTGGCATGGCAATGCCAATCACGCCATTTTTAGTCTATC
CTCGTTGGCTCGAGCTTCATCTAAGGATCTTGCGTATTTTGATAATCCTTTATTGCAGTCTGTCTTAAACTCTACCAGAG
CAGGTGCTGTTTTATTAAAGCCCGAGCATAAAGATTGGTGTCCTGTGAACTGTATTGTAGTTCCCAATCCGTCAGAATCA
ATGTTTAAAGCAGCAAAGTTCCTGCCTCACCCTGGTACCAATGTTTGCGGAATTCATCCTACAGCTCAAATCCACAAATC
TGCCCAAATAGGCCAACACGTATCAGTTGGTGCTAACAGCGTGATTGGTGAAAATGTACAATTGGATGATTACGTATCTA
TTGGTTCTGGTACGACCATTGAATCTTCAGTACTGATTGGCAGAGGAAGTCAGCTGGGTTCTGGAGCAATAATTCATTCT
GGTACAGTTTTGGGCCAATCTGTAATTATTGATTCTGGGTGTATTGTTGGTGCTGCCCCGTTTAATTGCTACAAGGAACA
TGGTGTCTGGCAACAAGCACCAAACTTTGGTGGAGTTGTAATTGGCCAAAGAACTCAAATCGGTGCAAATACAGTAATTC
ACAGAGGCTCAATTGGCGATACTTATTTAGGTGATGGAGTCTGTATAGACAGTTTAGTACTCATCGCGCATGATGTTTAT
ATAGGGAATAACACTGCTATTGCAGGTTCTGCTGCAATTGGTGCTTTAGTGCAAATAGGCAGTGATTGTATCATAGGTGG
AGCAAGTTGCCTTGCAGCGAACATTCGTTTGACTAATGATGTAGTAATAACAGGAATGTCTACTGTGACAAAATCCATCG
CTCGCCCCGGGATTTATTCTTCGGGAACGACGGTTCACGATCATCGCAAGTGGCGTCGTAACACAGCGCGATTCAGACAT
TTGGATGACTACATTACAAAGCTGATAACAATAGAAAAAAAATTGAATAATAACAACTAA

Upstream 100 bases:

>100_bases
TACGATATTATTGTTCAGAAAGATGCAGCGCCCTTCAGCAGCGAATCTCTTGATGTAACAGATAAAGTTATCAAAGCAAT
TAATTAATTCGGCGGATGCG

Downstream 100 bases:

>100_bases
TTATGTTTTATCAATTTGAAGTAACATTATTTTTGAAATTTTTAATTGATTAGAATGAGCTAAACCAAGATAATGAGCCA
TTTTGTAATGCAATAGGCGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPNPSES
MFKAAKFLPHPGTNVCGIHPTAQIHKSAQIGQHVSVGANSVIGENVQLDDYVSIGSGTTIESSVLIGRGSQLGSGAIIHS
GTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAHDVY
IGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTARFRH
LDDYITKLITIEKKLNNNN

Sequences:

>Translated_339_residues
MLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPNPSES
MFKAAKFLPHPGTNVCGIHPTAQIHKSAQIGQHVSVGANSVIGENVQLDDYVSIGSGTTIESSVLIGRGSQLGSGAIIHS
GTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAHDVY
IGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTARFRH
LDDYITKLITIEKKLNNNN
>Mature_339_residues
MLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPNPSES
MFKAAKFLPHPGTNVCGIHPTAQIHKSAQIGQHVSVGANSVIGENVQLDDYVSIGSGTTIESSVLIGRGSQLGSGAIIHS
GTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAHDVY
IGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTARFRH
LDDYITKLITIEKKLNNNN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=35.4838709677419, Blast_Score=218, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 35841; Mature: 35841

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLK
CCCHHHHHHHHCCEEECCCCCEEEEHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCEEEEC
PEHKDWCPVNCIVVPNPSESMFKAAKFLPHPGTNVCGIHPTAQIHKSAQIGQHVSVGANS
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCEEECCCCC
VIGENVQLDDYVSIGSGTTIESSVLIGRGSQLGSGAIIHSGTVLGQSVIIDSGCIVGAAP
CCCCCCEECCEEECCCCCEEECEEEEECCCCCCCCEEEECCCEECCEEEEECCCEEECCC
FNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAHDVY
CHHHHHCCCHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEHHEEEE
IGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYS
ECCCCEECCHHHHHHHHHCCCCEEECCHHHEEEEEEEECCEEEECHHHHHHHHHCCCCCC
SGTTVHDHRKWRRNTARFRHLDDYITKLITIEKKLNNNN
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLK
CCCHHHHHHHHCCEEECCCCCEEEEHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCEEEEC
PEHKDWCPVNCIVVPNPSESMFKAAKFLPHPGTNVCGIHPTAQIHKSAQIGQHVSVGANS
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCEEECCCCC
VIGENVQLDDYVSIGSGTTIESSVLIGRGSQLGSGAIIHSGTVLGQSVIIDSGCIVGAAP
CCCCCCEECCEEECCCCCEEECEEEEECCCCCCCCEEEECCCEECCEEEEECCCEEECCC
FNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAHDVY
CHHHHHCCCHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEHHEEEE
IGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYS
ECCCCEECCHHHHHHHHHCCCCEEECCHHHEEEEEEEECCEEEECHHHHHHHHHCCCCCC
SGTTVHDHRKWRRNTARFRHLDDYITKLITIEKKLNNNN
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA