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The map label for this gene is nox

Identifier: 54020439

GI number: 54020439

Start: 344263

End: 345645

Strand: Reverse

Name: nox

Synonym: mhp299

Alternate gene names: 54020439

Gene position: 345645-344263 (Counterclockwise)

Preceding gene: 54020440

Following gene: 54020438

Centisome position: 38.72

GC content: 33.19

Gene sequence:

>1383_bases
ATGAAAATTATATCAATTGGGACAAATCATGCTGGAACTTCGTTTCTAAGAACATTAAAAACTATTTATCCGCAGGCTGA
ACTTGTTACTTATGATAGAAATACTGATATCTCATTTTTAGGCTGTGGAATTGCGCTTTGAGTTTCTGATGAATTCAGTG
ATCCATCCGGACTTTTTTATTCAAGTCCTGAGCAATTAAAAAGTATGGGAATTAGCGTTAATTTAGAACATGATGTAATA
GGAATTGATCGTAAAAATAAGGAAGTTACTGTTAAAAACTTAGTTACTGGTCAAATTTTTAAGGATAATTATGATAAATT
AGTGTTTGCTGGTGGAACTTGGCCAATTATTCCTCCATTTGAAGGAATTAGTCTTGAAAATATTTTGGTCTCCAAAACTT
TTACCCATGCAAAAACCATTAAAGAAAAAGCGGTTGATCCATCTATAAAAAATGTAATTATTATTGGTGGAGGCTATATT
GGGATTGAATTACTTGAAGCTTTTCATAAATATGGCAAAAAAACTACCTTGATTGATATGCAAGATCGAATTATCCCAAA
CTACTTTGATCATGAATTTACCCAAAAAATGGAGGAAAAAATTCGTGCTGAAGGGATAAATCTTCAATTCGGGCAAAAAG
TTATGCGGTTTATCGCTGATGAAACAGGCAAAAAAGTAGCATTTGTTGAAACCGATAAAGGAAAATATGCCGCAGACCTT
GTTATTTTAGCAATCGGCTTTTCTCCGAATACAAAAATTTTAGCTGATGTTGAAAAAACTCCAAATGGTGCTATCAAAGT
TGATCAATTTCAACGTAGTTTAAGTGATGAAGATCTTTATGTAATTGGTGATTCAGCAGCTATGTTTCATAATGTAACTG
AAAAACATGCTCATATTGCCTTAGCAACAAATGCCGTAAAATCAGGAATAGTTGCTGCTTTTCACCTTGCTGGTCGCAGT
GATATTCCTTTTCCAGGTTATGTTGGAACTAATGCAATTTCCGTCTTCGGATTTAATTATGCATCAACTGGTTATTCTGA
AAGAGGTTGTTCATTAATGGGGCTCGAGGAGGTTGCAACTGCATATCTTGAGGACTGAGATCGCCCTGAATTTATGCAGG
AAAAAGCAAAAGTTTGAATTAAAATTACCTACCATAAACCAACTTTAAGATTACTTGGGGCCCAAATTGGATCATATGGG
AAACAATTTAACCATACAGAAGTAATTTATTTTCTTTCCCTGGCAATCCAAAAAAGGCTGAAATTAACAGAAATTGCTCT
TTCAGATTTTTATTTTCTCCCGCATTTTAACAAACCGTTTAACTTTGTAGTACAAGTAATTTTAAACGCTTTAGGGCTTA
GTTATAATAAAAAATTAAAATAA

Upstream 100 bases:

>100_bases
AATCTAAAAAAATGTTGTATAATTTTTTTAGATTAAAAATAAAATGATATTTATTTTTCCTTTTTATATAAATTTAAACC
AAAAACAGGAGTTATAATTT

Downstream 100 bases:

>100_bases
TTTTCTTAATTTTTTCCAATTTTCATTATTTAATAAAAACGGTTTCACTTTTAAAGTAGAACCGTTTTTTTTATTTTTTA
TAAAATTTTAGTAAAAAAAA

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKIISIGTNHAGTSFLRTLKTIYPQAELVTYDRNTDISFLGCGIALWVSDEFSDPSGLFYSSPEQLKSMGISVNLEHDVI
GIDRKNKEVTVKNLVTGQIFKDNYDKLVFAGGTWPIIPPFEGISLENILVSKTFTHAKTIKEKAVDPSIKNVIIIGGGYI
GIELLEAFHKYGKKTTLIDMQDRIIPNYFDHEFTQKMEEKIRAEGINLQFGQKVMRFIADETGKKVAFVETDKGKYAADL
VILAIGFSPNTKILADVEKTPNGAIKVDQFQRSLSDEDLYVIGDSAAMFHNVTEKHAHIALATNAVKSGIVAAFHLAGRS
DIPFPGYVGTNAISVFGFNYASTGYSERGCSLMGLEEVATAYLEDWDRPEFMQEKAKVWIKITYHKPTLRLLGAQIGSYG
KQFNHTEVIYFLSLAIQKRLKLTEIALSDFYFLPHFNKPFNFVVQVILNALGLSYNKKLK

Sequences:

>Translated_460_residues
MKIISIGTNHAGTSFLRTLKTIYPQAELVTYDRNTDISFLGCGIAL*VSDEFSDPSGLFYSSPEQLKSMGISVNLEHDVI
GIDRKNKEVTVKNLVTGQIFKDNYDKLVFAGGTWPIIPPFEGISLENILVSKTFTHAKTIKEKAVDPSIKNVIIIGGGYI
GIELLEAFHKYGKKTTLIDMQDRIIPNYFDHEFTQKMEEKIRAEGINLQFGQKVMRFIADETGKKVAFVETDKGKYAADL
VILAIGFSPNTKILADVEKTPNGAIKVDQFQRSLSDEDLYVIGDSAAMFHNVTEKHAHIALATNAVKSGIVAAFHLAGRS
DIPFPGYVGTNAISVFGFNYASTGYSERGCSLMGLEEVATAYLED*DRPEFMQEKAKV*IKITYHKPTLRLLGAQIGSYG
KQFNHTEVIYFLSLAIQKRLKLTEIALSDFYFLPHFNKPFNFVVQVILNALGLSYNKKLK
>Mature_460_residues
MKIISIGTNHAGTSFLRTLKTIYPQAELVTYDRNTDISFLGCGIAL*VSDEFSDPSGLFYSSPEQLKSMGISVNLEHDVI
GIDRKNKEVTVKNLVTGQIFKDNYDKLVFAGGTWPIIPPFEGISLENILVSKTFTHAKTIKEKAVDPSIKNVIIIGGGYI
GIELLEAFHKYGKKTTLIDMQDRIIPNYFDHEFTQKMEEKIRAEGINLQFGQKVMRFIADETGKKVAFVETDKGKYAADL
VILAIGFSPNTKILADVEKTPNGAIKVDQFQRSLSDEDLYVIGDSAAMFHNVTEKHAHIALATNAVKSGIVAAFHLAGRS
DIPFPGYVGTNAISVFGFNYASTGYSERGCSLMGLEEVATAYLED*DRPEFMQEKAKV*IKITYHKPTLRLLGAQIGSYG
KQFNHTEVIYFLSLAIQKRLKLTEIALSDFYFLPHFNKPFNFVVQVILNALGLSYNKKLK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1789065, Length=194, Percent_Identity=28.3505154639175, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786307, Length=368, Percent_Identity=25.8152173913043, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281359715, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281359713, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639250, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI18543267, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639252, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639257, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585130, Length=286, Percent_Identity=24.1258741258741, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 50801; Mature: 50801

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIISIGTNHAGTSFLRTLKTIYPQAELVTYDRNTDISFLGCGIALVSDEFSDPSGLFYS
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCC
SPEQLKSMGISVNLEHDVIGIDRKNKEVTVKNLVTGQIFKDNYDKLVFAGGTWPIIPPFE
CHHHHHHCCCEEEECCCEEECCCCCCEEEEEHHEECEEECCCCCEEEECCCCCCCCCCCC
GISLENILVSKTFTHAKTIKEKAVDPSIKNVIIIGGGYIGIELLEAFHKYGKKTTLIDMQ
CCCHHHEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECH
DRIIPNYFDHEFTQKMEEKIRAEGINLQFGQKVMRFIADETGKKVAFVETDKGKYAADLV
HCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEE
ILAIGFSPNTKILADVEKTPNGAIKVDQFQRSLSDEDLYVIGDSAAMFHNVTEKHAHIAL
EEEEECCCCCCEEEEECCCCCCCEEHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCEEEE
ATNAVKSGIVAAFHLAGRSDIPFPGYVGTNAISVFGFNYASTGYSERGCSLMGLEEVATA
EHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEECHHHHHHH
YLEDDRPEFMQEKAKVIKITYHKPTLRLLGAQIGSYGKQFNHTEVIYFLSLAIQKRLKLT
HHCCCCHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EIALSDFYFLPHFNKPFNFVVQVILNALGLSYNKKLK
HHHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKIISIGTNHAGTSFLRTLKTIYPQAELVTYDRNTDISFLGCGIALVSDEFSDPSGLFYS
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCC
SPEQLKSMGISVNLEHDVIGIDRKNKEVTVKNLVTGQIFKDNYDKLVFAGGTWPIIPPFE
CHHHHHHCCCEEEECCCEEECCCCCCEEEEEHHEECEEECCCCCEEEECCCCCCCCCCCC
GISLENILVSKTFTHAKTIKEKAVDPSIKNVIIIGGGYIGIELLEAFHKYGKKTTLIDMQ
CCCHHHEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECH
DRIIPNYFDHEFTQKMEEKIRAEGINLQFGQKVMRFIADETGKKVAFVETDKGKYAADLV
HCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEE
ILAIGFSPNTKILADVEKTPNGAIKVDQFQRSLSDEDLYVIGDSAAMFHNVTEKHAHIAL
EEEEECCCCCCEEEEECCCCCCCEEHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCEEEE
ATNAVKSGIVAAFHLAGRSDIPFPGYVGTNAISVFGFNYASTGYSERGCSLMGLEEVATA
EHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEECHHHHHHH
YLEDDRPEFMQEKAKVIKITYHKPTLRLLGAQIGSYGKQFNHTEVIYFLSLAIQKRLKLT
HHCCCCHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EIALSDFYFLPHFNKPFNFVVQVILNALGLSYNKKLK
HHHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]