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The map label for this gene is hemK

Identifier: 54020409

GI number: 54020409

Start: 266761

End: 267477

Strand: Reverse

Name: hemK

Synonym: mhp242

Alternate gene names: 54020409

Gene position: 267477-266761 (Counterclockwise)

Preceding gene: 54020410

Following gene: 54020408

Centisome position: 29.96

GC content: 29.15

Gene sequence:

>717_bases
ATGCTAATAAATAAGCGCAAATTAGAACTTTTAAAAGAAAAACAGCGATATAATTTACCTCTTAAGATCTCAAAATTGGA
AAATTTAAAGTTAGAACTGGACTATCCGATCCAAAAAATTATTGGATTTATTGAAATGGAAGGCGTTAAAATTTTCCTTG
ATCAAAAAGTTTTCATCCCGCGCTATGAAACCCAGGAATTAATTCTTAAAATAAAAAAAGTAATAAAAAAAGGTGATTTG
GTCCTTGATTTATGTTCTGGATCAGGTTTTATCGGTCTTGCGCTTGCTAAATTTATTAATGCAAAAATAACTCTGGCAGA
TATAAGTGATGAGGCAATTCTTCAGGCAAAGCTTAATGCAAAATATAATAATTTAGAGCTAAATATCATAAAATCCGACC
TTTTTGCGAATATTCCTGAGCAAAAATTTAATATAATAGTTGCAAATCCGCCTTATTTAAAAGAAGAAAAACTAGCTAAT
TCAGTGCTTAATTTTGAACCAAAAACCGCCTTGTTTGCATGGCCTGAGCCTTTTTCATTCTATGAAAAAATTCTTGAAAA
AATTGGTAATTTTTTAGCCGACGATGGTTGAATTTTTTTTGAAATTGACTATAATAGTCAAGATTTTTTCAAGAAAAACT
ACCCTGATTTTATAATTGAAAAAGATATAAATGGGAAAACAAGATTTGCTTACTGACAAAAAACGGCAAAAAAGTAA

Upstream 100 bases:

>100_bases
AATTTTTCTACCTCACTAAAACCAATAATTCAAGGGAACCTAAATCCAATAATTGAAGCCTTACTTGCCCAAGAAAAAAC
GGAACTAATTCTCCAAAATT

Downstream 100 bases:

>100_bases
AGAATTTATAACATTTTTTAAAAATTAGTTTTTAAAAAATTTGACTTTGAAAGGAATTTAATGAAAATAAGAACTCGCTA
TGCTCCTTCACCGACCGGAT

Product: protoporphirogen oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLINKRKLELLKEKQRYNLPLKISKLENLKLELDYPIQKIIGFIEMEGVKIFLDQKVFIPRYETQELILKIKKVIKKGDL
VLDLCSGSGFIGLALAKFINAKITLADISDEAILQAKLNAKYNNLELNIIKSDLFANIPEQKFNIIVANPPYLKEEKLAN
SVLNFEPKTALFAWPEPFSFYEKILEKIGNFLADDGWIFFEIDYNSQDFFKKNYPDFIIEKDINGKTRFAYWQKTAKK

Sequences:

>Translated_238_residues
MLINKRKLELLKEKQRYNLPLKISKLENLKLELDYPIQKIIGFIEMEGVKIFLDQKVFIPRYETQELILKIKKVIKKGDL
VLDLCSGSGFIGLALAKFINAKITLADISDEAILQAKLNAKYNNLELNIIKSDLFANIPEQKFNIIVANPPYLKEEKLAN
SVLNFEPKTALFAWPEPFSFYEKILEKIGNFLADDG*IFFEIDYNSQDFFKKNYPDFIIEKDINGKTRFAY*QKTAKK
>Mature_238_residues
MLINKRKLELLKEKQRYNLPLKISKLENLKLELDYPIQKIIGFIEMEGVKIFLDQKVFIPRYETQELILKIKKVIKKGDL
VLDLCSGSGFIGLALAKFINAKITLADISDEAILQAKLNAKYNNLELNIIKSDLFANIPEQKFNIIVANPPYLKEEKLAN
SVLNFEPKTALFAWPEPFSFYEKILEKIGNFLADDG*IFFEIDYNSQDFFKKNYPDFIIEKDINGKTRFAY*QKTAKK

Specific function: Unknown

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=237, Percent_Identity=26.5822784810127, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87082085, Length=175, Percent_Identity=33.1428571428571, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787463, Length=203, Percent_Identity=29.064039408867, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR017127
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 27331; Mature: 27331

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINKRKLELLKEKQRYNLPLKISKLENLKLELDYPIQKIIGFIEMEGVKIFLDQKVFIP
CCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCHHHHHHHHEECCEEEEECCEEECC
RYETQELILKIKKVIKKGDLVLDLCSGSGFIGLALAKFINAKITLADISDEAILQAKLNA
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCEEEEECCC
KYNNLELNIIKSDLFANIPEQKFNIIVANPPYLKEEKLANSVLNFEPKTALFAWPEPFSF
CCCCEEEEEEECHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHH
YEKILEKIGNFLADDGIFFEIDYNSQDFFKKNYPDFIIEKDINGKTRFAYQKTAKK
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCEEEEECCCCCEEEEEHHHCCC
>Mature Secondary Structure
MLINKRKLELLKEKQRYNLPLKISKLENLKLELDYPIQKIIGFIEMEGVKIFLDQKVFIP
CCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCHHHHHHHHEECCEEEEECCEEECC
RYETQELILKIKKVIKKGDLVLDLCSGSGFIGLALAKFINAKITLADISDEAILQAKLNA
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCEEEEECCC
KYNNLELNIIKSDLFANIPEQKFNIIVANPPYLKEEKLANSVLNFEPKTALFAWPEPFSF
CCCCEEEEEEECHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHH
YEKILEKIGNFLADDGIFFEIDYNSQDFFKKNYPDFIIEKDINGKTRFAYQKTAKK
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCEEEEECCCCCEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]