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The map label for this gene is uvrB

Identifier: 54020288

GI number: 54020288

Start: 842990

End: 845029

Strand: Direct

Name: uvrB

Synonym: mhp669

Alternate gene names: 54020288

Gene position: 842990-845029 (Clockwise)

Preceding gene: 54020287

Following gene: 54020289

Centisome position: 94.43

GC content: 32.25

Gene sequence:

>2040_bases
ATGTTTTGTGTTAAAATTTTCTTAAAAAATTTTAAAAAAGTAATCGGTTTTAATATGTTAATTGAAAAAGAATTTAAAAA
ATTCAAACTAGTTGCAAATTATAAACCAAGCGGTGATCAGCCAAAAGCAATAAAAAATTTAATCAACGGGATAAAATCCG
GAAAAAAATCCCAAGTTTTGCTTGGAGTAACAGGATCTGGAAAAACCTTTACAATGGCGAATGTAATTGCCTATTTTAAC
AAACCAGTAATAATTTTATCACATAATAAAACTTTAGCCTCACAATTATATAGTGAATTTAAGGAGTTTTTCCCGGAAAA
CCGCGTTGAATTTTATATTTCCTACTTTGATTTTTACCGGCCAGAAGCTTATTTGCCAACAAAAGATGTCTATTTAGAAA
AAACTAGTAAAACAAATTTTGACCTTGAAACTATGCGAATGTCAGCCCTAAACGCCTTGATGATGCGAAATGATACAATC
GTTATTGCCTCGGTTGCTGCAATTTATGGGACCTTAAACCCGGATGAATATCAGGATAATTTCTTAGTTTTAGAGGTAGA
TCAGGAAATAAAACCAAATGAATTAGCCCTAAAACTTGCCAGAATCAAGTATGAAAATAATCAAATTGAGCAAAAACCGG
GAATTTTTTCTTTAAAAGGTGATGTTTTAGAAATTTTTCCAGCTTGAAGTGATGCTTTTAATATCAGAGTGGAATTTTTT
GGAAATATAATTGAGACAATAAACATAATTCATCCAGTTTCAAAATCAATAATAAAATCATATAATTCTTTCACAGTTTA
TCCCGCAACTGCTTATAGTGTGAAAAAAAATATAATTAACAGAGCAATCGAAACCATCAAAATTGAGCTGGCTGAACAGC
TCCAATTTTTTGAAAAAAATAATAAATTAGTCGAAAAACAACGACTAAAAGACCGAGTCAATAATGATGTTGACTCGCTT
TCTGAATTCGGAATTTGTTCAGGAATTGAGAATTATGCCCGTCATATTGACGGACGACAAAAAGGCGAAAAACCATTTAG
TTTACTAGATTATTTACCGCAAGACGGCCTAATTTTTATTGATGAATCCCATATTATGATCAGCCAAATTAAGGGCATGT
ATGAAGGTGATCGAAGCCGAAAACAAACCTTGGTTGACTATGGTTATCGACTACCTTCAGCTCTTGATAATCGGCCTTTA
AAACTCAGTGAATTTGAGGAATATCAGCATGCAAAAATTTATGTTTCAGCCACACCAGCCAGCTATGAAATTGATAAAGC
AAATGGCGAAATTGTCTCGCAAATTATCAGGCCAACCGGACTAATTGATCCAGAAATAGTAATTGAATCTACCAAAAATC
AAATGGAGAAAATTTTTCAGTATTTACTAAAACAGAAGAAAAAAAAAGAAAGAAGTCTCATCTTAACTACCACAAAACGA
CTGGCCGAAGAAATCAGCAAGTATCTCCAGGAAGAAAAATTACAAAATGTCTATTATTTGCACTCAGAAATGACGACTTT
TGAACGCGATGAAATCATAATTAAGCTTCGAAAAGGAATTTATGATGCAATTGTCGGTATAAATTTACTTCGTGAAGGCG
TTGATATCCCGGAAGTTTCTTTGATTTTTGTTCTTGAAGCCGGTCTTGTTTCTTTTCTGCGATCAGAATCTTCCTTAATC
CAAATTATCGGGCGGGCTGCCCGTAACGATCATGGAAAAGTTATCCTTTTTACCGATACAGTCACTGAAACTATTGAAAA
AGTTTTAAAAGATAATGAAAATAAAAGAAAAATTCAAATTGAATACAACCAAAAAAACAAAATTATCCCAAAAACAATAA
AAAAACCGATTCCCGACAGCATCAATCCAAACAGTTTGAAAATCAGCAAAGTCCTTCGTGAAAAACAAAAAAACAAAAAA
GAGGTGGAAAATTACATCAAAATTCTCGAAAAAGAAATGAAAATAGCCGCAGATGCAAATCGTTTTGAGGAAGCAATTCA
AATTCGTGATTTGATTGCCGAAATTAAATTAAAAATTTAA

Upstream 100 bases:

>100_bases
AGTGGCTTTTCTAAAAAAGAAAAATTACAAATATTTAAAAAAGTACTAATTCCAAAAGCATTTTTTGAATATAAAAACCA
AAAAATGCTTAAAAACAAAG

Downstream 100 bases:

>100_bases
TAAATTATAAAAAATTCAGCTATGAATACAAAAATTCAGATAATTTTTGGGCAAAAAGGTGCTAATTTGACCTTTTTAGA
TTCACAAAGTCAAAAAAAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MFCVKIFLKNFKKVIGFNMLIEKEFKKFKLVANYKPSGDQPKAIKNLINGIKSGKKSQVLLGVTGSGKTFTMANVIAYFN
KPVIILSHNKTLASQLYSEFKEFFPENRVEFYISYFDFYRPEAYLPTKDVYLEKTSKTNFDLETMRMSALNALMMRNDTI
VIASVAAIYGTLNPDEYQDNFLVLEVDQEIKPNELALKLARIKYENNQIEQKPGIFSLKGDVLEIFPAWSDAFNIRVEFF
GNIIETINIIHPVSKSIIKSYNSFTVYPATAYSVKKNIINRAIETIKIELAEQLQFFEKNNKLVEKQRLKDRVNNDVDSL
SEFGICSGIENYARHIDGRQKGEKPFSLLDYLPQDGLIFIDESHIMISQIKGMYEGDRSRKQTLVDYGYRLPSALDNRPL
KLSEFEEYQHAKIYVSATPASYEIDKANGEIVSQIIRPTGLIDPEIVIESTKNQMEKIFQYLLKQKKKKERSLILTTTKR
LAEEISKYLQEEKLQNVYYLHSEMTTFERDEIIIKLRKGIYDAIVGINLLREGVDIPEVSLIFVLEAGLVSFLRSESSLI
QIIGRAARNDHGKVILFTDTVTETIEKVLKDNENKRKIQIEYNQKNKIIPKTIKKPIPDSINPNSLKISKVLREKQKNKK
EVENYIKILEKEMKIAADANRFEEAIQIRDLIAEIKLKI

Sequences:

>Translated_679_residues
MFCVKIFLKNFKKVIGFNMLIEKEFKKFKLVANYKPSGDQPKAIKNLINGIKSGKKSQVLLGVTGSGKTFTMANVIAYFN
KPVIILSHNKTLASQLYSEFKEFFPENRVEFYISYFDFYRPEAYLPTKDVYLEKTSKTNFDLETMRMSALNALMMRNDTI
VIASVAAIYGTLNPDEYQDNFLVLEVDQEIKPNELALKLARIKYENNQIEQKPGIFSLKGDVLEIFPA*SDAFNIRVEFF
GNIIETINIIHPVSKSIIKSYNSFTVYPATAYSVKKNIINRAIETIKIELAEQLQFFEKNNKLVEKQRLKDRVNNDVDSL
SEFGICSGIENYARHIDGRQKGEKPFSLLDYLPQDGLIFIDESHIMISQIKGMYEGDRSRKQTLVDYGYRLPSALDNRPL
KLSEFEEYQHAKIYVSATPASYEIDKANGEIVSQIIRPTGLIDPEIVIESTKNQMEKIFQYLLKQKKKKERSLILTTTKR
LAEEISKYLQEEKLQNVYYLHSEMTTFERDEIIIKLRKGIYDAIVGINLLREGVDIPEVSLIFVLEAGLVSFLRSESSLI
QIIGRAARNDHGKVILFTDTVTETIEKVLKDNENKRKIQIEYNQKNKIIPKTIKKPIPDSINPNSLKISKVLREKQKNKK
EVENYIKILEKEMKIAADANRFEEAIQIRDLIAEIKLKI
>Mature_679_residues
MFCVKIFLKNFKKVIGFNMLIEKEFKKFKLVANYKPSGDQPKAIKNLINGIKSGKKSQVLLGVTGSGKTFTMANVIAYFN
KPVIILSHNKTLASQLYSEFKEFFPENRVEFYISYFDFYRPEAYLPTKDVYLEKTSKTNFDLETMRMSALNALMMRNDTI
VIASVAAIYGTLNPDEYQDNFLVLEVDQEIKPNELALKLARIKYENNQIEQKPGIFSLKGDVLEIFPA*SDAFNIRVEFF
GNIIETINIIHPVSKSIIKSYNSFTVYPATAYSVKKNIINRAIETIKIELAEQLQFFEKNNKLVEKQRLKDRVNNDVDSL
SEFGICSGIENYARHIDGRQKGEKPFSLLDYLPQDGLIFIDESHIMISQIKGMYEGDRSRKQTLVDYGYRLPSALDNRPL
KLSEFEEYQHAKIYVSATPASYEIDKANGEIVSQIIRPTGLIDPEIVIESTKNQMEKIFQYLLKQKKKKERSLILTTTKR
LAEEISKYLQEEKLQNVYYLHSEMTTFERDEIIIKLRKGIYDAIVGINLLREGVDIPEVSLIFVLEAGLVSFLRSESSLI
QIIGRAARNDHGKVILFTDTVTETIEKVLKDNENKRKIQIEYNQKNKIIPKTIKKPIPDSINPNSLKISKVLREKQKNKK
EVENYIKILEKEMKIAADANRFEEAIQIRDLIAEIKLKI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=46.6165413533835, Blast_Score=596, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78162; Mature: 78162

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCVKIFLKNFKKVIGFNMLIEKEFKKFKLVANYKPSGDQPKAIKNLINGIKSGKKSQVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEE
LGVTGSGKTFTMANVIAYFNKPVIILSHNKTLASQLYSEFKEFFPENRVEFYISYFDFYR
EEEECCCCEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
PEAYLPTKDVYLEKTSKTNFDLETMRMSALNALMMRNDTIVIASVAAIYGTLNPDEYQDN
CCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCC
FLVLEVDQEIKPNELALKLARIKYENNQIEQKPGIFSLKGDVLEIFPASDAFNIRVEFFG
EEEEEECCCCCCHHHHHHHHHEEECCCCCCCCCCEEEECCCEEEEEECCCCEEEEHHHHH
NIIETINIIHPVSKSIIKSYNSFTVYPATAYSVKKNIINRAIETIKIELAEQLQFFEKNN
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KLVEKQRLKDRVNNDVDSLSEFGICSGIENYARHIDGRQKGEKPFSLLDYLPQDGLIFID
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEE
ESHIMISQIKGMYEGDRSRKQTLVDYGYRLPSALDNRPLKLSEFEEYQHAKIYVSATPAS
CCCCHHHHHCCHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHCCCCEEEEEEECCCC
YEIDKANGEIVSQIIRPTGLIDPEIVIESTKNQMEKIFQYLLKQKKKKERSLILTTTKRL
EEEECCCHHHHHHHHHHCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHH
AEEISKYLQEEKLQNVYYLHSEMTTFERDEIIIKLRKGIYDAIVGINLLREGVDIPEVSL
HHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IFVLEAGLVSFLRSESSLIQIIGRAARNDHGKVILFTDTVTETIEKVLKDNENKRKIQIE
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEE
YNQKNKIIPKTIKKPIPDSINPNSLKISKVLREKQKNKKEVENYIKILEKEMKIAADANR
ECCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEEAIQIRDLIAEIKLKI
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFCVKIFLKNFKKVIGFNMLIEKEFKKFKLVANYKPSGDQPKAIKNLINGIKSGKKSQVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEE
LGVTGSGKTFTMANVIAYFNKPVIILSHNKTLASQLYSEFKEFFPENRVEFYISYFDFYR
EEEECCCCEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
PEAYLPTKDVYLEKTSKTNFDLETMRMSALNALMMRNDTIVIASVAAIYGTLNPDEYQDN
CCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCC
FLVLEVDQEIKPNELALKLARIKYENNQIEQKPGIFSLKGDVLEIFPASDAFNIRVEFFG
EEEEEECCCCCCHHHHHHHHHEEECCCCCCCCCCEEEECCCEEEEEECCCCEEEEHHHHH
NIIETINIIHPVSKSIIKSYNSFTVYPATAYSVKKNIINRAIETIKIELAEQLQFFEKNN
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KLVEKQRLKDRVNNDVDSLSEFGICSGIENYARHIDGRQKGEKPFSLLDYLPQDGLIFID
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEE
ESHIMISQIKGMYEGDRSRKQTLVDYGYRLPSALDNRPLKLSEFEEYQHAKIYVSATPAS
CCCCHHHHHCCHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHCCCCEEEEEEECCCC
YEIDKANGEIVSQIIRPTGLIDPEIVIESTKNQMEKIFQYLLKQKKKKERSLILTTTKRL
EEEECCCHHHHHHHHHHCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHH
AEEISKYLQEEKLQNVYYLHSEMTTFERDEIIIKLRKGIYDAIVGINLLREGVDIPEVSL
HHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IFVLEAGLVSFLRSESSLIQIIGRAARNDHGKVILFTDTVTETIEKVLKDNENKRKIQIE
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEE
YNQKNKIIPKTIKKPIPDSINPNSLKISKVLREKQKNKKEVENYIKILEKEMKIAADANR
ECCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEEAIQIRDLIAEIKLKI
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]