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The map label for this gene is mutL

Identifier: 52842903

GI number: 52842903

Start: 3049445

End: 3051175

Strand: Reverse

Name: mutL

Synonym: lpg2697

Alternate gene names: 52842903

Gene position: 3051175-3049445 (Counterclockwise)

Preceding gene: 52842904

Following gene: 52842902

Centisome position: 89.8

GC content: 40.79

Gene sequence:

>1731_bases
ATGGTCTTAAGGATACATCAACTTTCGCCAGCAATAGCCAATCAGATTGCAGCAGGAGAAGTTATAGAAAGACCTGCTTC
GGTAGTCAAGGAGCTGCTGGAAAACTCTTTGGATGCTGGTGCCAGTGTGATTGGTGTCGATGTCAATTATGGGGGATTGC
TGCAGATTACGGTTAGTGATAATGGTTCAGGAATCGTTGGAGACGACTTGCCTTTAGCTATTGCAGCTCATGCAACCAGT
AAAATCAGAACGCTTGATGATTTATATTCCATTGATAGTATGGGCTTTAGAGGGGAGGCATTGGCAAGTATTGCCTCTGT
TGCCAAAGTGACTATCATTTCAAAGCCTGAGGAGCAGGACAATGCAATGATGTTGCGAGTAGAGGGGGAGAACAGGACTC
TCTCTCCTTGTGCGCGCAATATTGGCACTACCATTGATGTTTCTGATTTGTTCTATAATGCCCCAGTTCGTAAGCGGTTT
TTAAAAAATGAAAAACTGGAATTTCAAGCTATTGAAATGGTTGTGAAACGGTTTGCATTAAGCGCTCCTCAGATTGCATT
AACGCTTAAGCATAATAAGAAACTGATTTTTTCATTACCGCCAGCCTTAAGTGAGCAAGCCAAAGCCATTCGTATGGGTC
GAATTTTGGGCAATACTTTCATGAGAGAAGCTATTTTTCTTGATGTGGAGCACAGTGGTATGCGTCTTTATGGCTGGATA
AGCAACCATCGCTTGCAACGCAGCCAGAATGATAGGCAGTGGATTTATGTGAATCAACGCATGGTAAAGGATAAATTACT
CCAACATGCAGTGAAACAAGCGTATGATGGCTTATTGCATGCAGGCAGATTTCCAATTTGTTTGTTGTATTTTACTTTAC
CTGCTTCTGAAGTGGATGTGAATGTACATCCTACAAAGCATGAAGTGAGATTCCAACAGCCCCGCCTGGTACATGATTTT
TTTACTTCCCAATTGACGAAAGCGTTGCAATCGACTCTTGACCATTCAGAAACAATGGAATACGCATATGCTGCTTCCTC
TTGTAATGAGCAGCAAAATACAGTTTCGGAACCTTCCCATATCTGCAATGACAGAGAGTCCTATGAAGGGGCAAGAGCTT
TATCCCCAAGCTGGAGTGACAATTCATTATCATCATCTATAACCTGCAAAGGGTATAAAAAAACCAGCTCTGTATATCAT
CCAGAAACAGAGTTCCAGTGGGTTATCTTAAATGAGCGGTTTATTTTGGTTTTGATAAAGCAACAGCCTTACCTTGTAGA
CATCGTAACATTGTTTCAAGAATGGATAGAAAAGCAGCTAATGCAAAAGGCATTGCCCTTGGAGAGCCGGCCTTTATTGA
TCTCAATTCGTTATCCATTACCAAACCAATGGATACATAAGCTGGATCACTTAAAGCATGAGTTGACTCGTGTTGGAATA
CAGATTGAGTACCCTAATGCTGATGACTTGTTAATTCGCAGCATCCCTTTGAATGCGCCCTATTTAGATGTTCGTCGTTT
TTTTAATGTTCTCTGCGAACTGGATTTTTTTGATACTGAGCAATTGATAGCGTTAATTAGCCGTTCTCAAATGTTTGACC
CAAAACAATTAACAGTTGAAGAGCGTATTGAAATGAATCAATTGTTGCTGGAACTCTCTCTTCAAGAAGAGAAATGTAAT
ACATGTAAAGCGTTAACCATTGATGATTGTCGGATGTTATTGCATGAATAA

Upstream 100 bases:

>100_bases
CTGCTCGATATAGGGTATCTGTGAACGCATTACAATCAATTAACCGCCTTCAGGCAAGGGCAAGACTTATGCCCGGGCAA
AAATTAGTGATACCTGGCAC

Downstream 100 bases:

>100_bases
GCTAGTGTTTTGTTTAATGGGACCAACTGCTTCAGGAAAGACAGGATTAGCATGCGAGTTGCTAACTCATTTCCCTTTTG
AAATTATTAGTGTTGATTCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAIAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPQIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSETMEYAYAASSCNEQQNTVSEPSHICNDRESYEGARALSPSWSDNSLSSSITCKGYKKTSSVYH
PETEFQWVILNERFILVLIKQQPYLVDIVTLFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKLDHLKHELTRVGI
QIEYPNADDLLIRSIPLNAPYLDVRRFFNVLCELDFFDTEQLIALISRSQMFDPKQLTVEERIEMNQLLLELSLQEEKCN
TCKALTIDDCRMLLHE

Sequences:

>Translated_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAIAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPQIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSETMEYAYAASSCNEQQNTVSEPSHICNDRESYEGARALSPSWSDNSLSSSITCKGYKKTSSVYH
PETEFQWVILNERFILVLIKQQPYLVDIVTLFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKLDHLKHELTRVGI
QIEYPNADDLLIRSIPLNAPYLDVRRFFNVLCELDFFDTEQLIALISRSQMFDPKQLTVEERIEMNQLLLELSLQEEKCN
TCKALTIDDCRMLLHE
>Mature_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAIAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPQIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSETMEYAYAASSCNEQQNTVSEPSHICNDRESYEGARALSPSWSDNSLSSSITCKGYKKTSSVYH
PETEFQWVILNERFILVLIKQQPYLVDIVTLFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKLDHLKHELTRVGI
QIEYPNADDLLIRSIPLNAPYLDVRRFFNVLCELDFFDTEQLIALISRSQMFDPKQLTVEERIEMNQLLLELSLQEEKCN
TCKALTIDDCRMLLHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=37.6996805111821, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=32.0121951219512, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=32.0121951219512, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=30.5295950155763, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4505913, Length=329, Percent_Identity=28.2674772036474, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=329, Percent_Identity=28.2674772036474, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI91992160, Length=265, Percent_Identity=28.3018867924528, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI91992162, Length=265, Percent_Identity=28.3018867924528, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI263191589, Length=224, Percent_Identity=33.4821428571429, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=26.1168384879725, Blast_Score=100, Evalue=7e-21,
Organism=Escherichia coli, GI1790612, Length=588, Percent_Identity=34.3537414965986, Blast_Score=309, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=33.4365325077399, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=349, Percent_Identity=27.2206303724928, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=390, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=414, Percent_Identity=31.1594202898551, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325093, Length=314, Percent_Identity=28.0254777070064, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=101, Percent_Identity=41.5841584158416, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=320, Percent_Identity=36.875, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=28.2122905027933, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65517; Mature: 65517

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
NGSGIVGDDLPLAIAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEEECCCCCEEEEHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHC
SAPQIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEH
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDV
HCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSETMEYAYAASSCNEQQNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCHH
ICNDRESYEGARALSPSWSDNSLSSSITCKGYKKTSSVYHPETEFQWVILNERFILVLIK
HHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCEEEEEECCCEEEEEEC
QQPYLVDIVTLFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKLDHLKHELTRVGI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEE
QIEYPNADDLLIRSIPLNAPYLDVRRFFNVLCELDFFDTEQLIALISRSQMFDPKQLTVE
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQLLLELSLQEEKCNTCKALTIDDCRMLLHE
HHHHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHHCC
>Mature Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
NGSGIVGDDLPLAIAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEEECCCCCEEEEHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHC
SAPQIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEH
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDV
HCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSETMEYAYAASSCNEQQNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCHH
ICNDRESYEGARALSPSWSDNSLSSSITCKGYKKTSSVYHPETEFQWVILNERFILVLIK
HHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCEEEEEECCCEEEEEEC
QQPYLVDIVTLFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKLDHLKHELTRVGI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEE
QIEYPNADDLLIRSIPLNAPYLDVRRFFNVLCELDFFDTEQLIALISRSQMFDPKQLTVE
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQLLLELSLQEEKCNTCKALTIDDCRMLLHE
HHHHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA