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The map label for this gene is murC

Identifier: 52842820

GI number: 52842820

Start: 2949745

End: 2951154

Strand: Reverse

Name: murC

Synonym: lpg2614

Alternate gene names: 52842820

Gene position: 2951154-2949745 (Counterclockwise)

Preceding gene: 52842821

Following gene: 52842819

Centisome position: 86.86

GC content: 42.34

Gene sequence:

>1410_bases
TTGAATAACTCAGAGCAATTTTTATCTCCGCGCATGGGGCGTGTAGAGCAAATTCATTTTGTTGGCATTGGTGGTGCTGG
TATGTGTGGTATTGCCGAAGTATTGCATAACCAGGGCTACCGTATTACTGGTTCGGATCTCGGAGAAAGTGGCACGGTAC
AACGCTTAAGGTCATTAGGTATTCAAGTCTATATCGGTCACAGGCTGGAAAACATTAAAGGCGCTGATGTTGTAGTAAGG
TCTTCGGCCGTTGATTTTAATAATCCTGAAATTGTGGCTGCTCGTGAGTTAATGATTCCAGTTATTCCTAGAGCAGCTAT
GCTTGCTGAGCTAATGCGATTTAGGCATGGTATAGCAATTGCCGGCACTCATGGCAAAACGACAACAACGAGCTTGGTCA
GTAGTTTGCTTGCTGAAGGTGGTTTGGATCCCAGTTTTGTTATTGGCGGAAAGCTGAATAGTTGTGGTGCGAATGCTCAG
CTTGGAAAGTCAGCTTATTTTGTTGTAGAGGCTGATGAGAGCGACGCCTCGTTTTTGTTTTTGAAGCCTATGATGGCGGT
AGTGACTAATATTGATGCTGATCACATGGATACTTATGAAGGTGATTTTGAAAAATTAAGAACAACATTTTTGGAATTTT
TGCATCATTTGCCTTTTTATGGATTAGCAGTAGTTTGTTTGGAAGATGAAGAAATTTGCCGTATCCTCCCGGCTATTCAA
AGACCAACCTTAACTTATGGGTTTAAAGAAGAGGCTCATTATCGGGCAATTAATTGGACTCAAAAGGGCATGCTGAGTGA
GTTTGTGGTCGTTCGACCTGCACCACATAAACAACTGACTATACAATTTCAGTATCCAGGCCGTCACAATGTATTAAATG
CATTAGCTTCTATAGCAATTGCCACTGAGTTGGGAGTTGATGACGATTCCATTGTTCGTGGCTTACAAAAATTCCAAGGG
GTGGGACGCCGCTTTCAAATGCTTGGTGAAAAACAGTTCGAAAAAGGCGCGGCGATTATTGTGGATGATTATGGACATCA
TCCACAGGAAATTTTATCCACAATTGATGCTTTTAGACGTGTTTGGCCCGAGAGACGTTTGGTTCATGTCTTTCAACCCC
ATCGTTATACCAGAACACAGTCCTTGCATAGACAATTTGTCGATGTTTTAAGTTTATCGGATGAGCTGTTATTGATGGAT
ATCTATGCAGCGGGAGAAACAGCTATTCCAGGCGTTACCAGTGAAAATCTGGCCAATGAAATACGATCCAGGGATAAACG
AGTGACCATAGTGAGCGAGCAATCGTTGAAAGCCACCTTAGATGAATTTATTAAAGATGGTGACGTTATTTTGATGCAGG
GAGCTGGAAGTATCGGCCAAATAGCAGTGAACCTGATGAAAAACATGTGA

Upstream 100 bases:

>100_bases
GGTAATTAATTGTATCGTTATTGCACTATTATTGCGCATAGATCATGAAAATCGTTGGCAGTCTCTTGGGTTGAGACCGC
TAACGGCTTAAGGGGGAATA

Downstream 100 bases:

>100_bases
GAATGAACATGAGCATAACGGGAATGGACAGCAGTCATGTAACAGAGTCTCAGGGCACTTTGCTTTTCAATGAGCCTTTG
GCTGAGTATACTACCTGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQIAVNLMKNM

Sequences:

>Translated_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQIAVNLMKNM
>Mature_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQIAVNLMKNM

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=54.2116630669546, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=28.6075949367089, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51965; Mature: 51965

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQIAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQIAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA