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The map label for this gene is coaBC [H]

Identifier: 52842696

GI number: 52842696

Start: 2801951

End: 2803339

Strand: Reverse

Name: coaBC [H]

Synonym: lpg2488

Alternate gene names: 52842696

Gene position: 2803339-2801951 (Counterclockwise)

Preceding gene: 52842699

Following gene: 52842695

Centisome position: 82.51

GC content: 41.11

Gene sequence:

>1389_bases
TTGTTACCCGAACTGATGAAAACGGCTAACAATTCAATATCAGAGAGGCTATGTACTCCATTAGTAAGTAGTTTTTCGCG
CAAGTCAAGTTGCTGCGCTGTATGGGCAACCATCATTTTGTATTCCTTTTATATTCCTTTATTGCGAAGTTTGTGCTTTG
ATCGGGGTTATTCTTATCAAAAATGGCGATCCATGCAAGATTTTATTAATAAAAAAATTCTACTTGGTGTTTGTGGCGGC
ATTGCTGCTTATAAATCTGCTCATCTGGTTAGAGAGTTAACTCGTTTGGGGGCCGATGTGAGGGTTGTCATGACTCATTC
AGCACAACAGTTCATTAACCCTTTATTGATGCAGGCATTATCAGGCAATGAAGTGAGGATTGATTTATTCGACACTCAAG
CTGAACGGGCTATGGGACATATTGAATTAGCCAGATGGGCAGATTATTTGCTCATTGCTCCTGCGTCTGCAAATTGTCTT
GCTAAAATGGCTCAAGGTCTTGCTGATGATTTGCTTTCAACATTATATCTCGTTACTGAAACGCCAGTTATTGTTTGTCC
TGCCATGAACAGAAGCATGTGGGCACATCCAGCAACCAAGGCAAATTGTGAATTGTTAAAAGAACGAGGTGTGTTTTTTG
TCGGGCCTGAAGAAGGCTCCCAGGCCTGTGGGGAACATGGATTGGGAAGAGTCAGCGAGGCGGATCAAATTGTGAATACC
TTGCGCTTACTGGATGTGAATCAACTATTGCATGGCAAACGAATTGTGATTACTGCAGGCCCTACTCGCGAGTCGATTGA
TCCAGTTCGTTATTTAAGCAATTACAGTTCAGGGAAGATGGGTTTTGCAATGGCTGAAGCCGCCGCTATGGCAGGCGCAC
AAGTGACATTAATTAGTGGTCCTTGTCATTTACAAACGTTTTCGGACATCGAGGTCATAAGAGTGGAGTCTGCACAATCG
ATGCTGGAAGAAGTGAACAGACATGTACAACAGGGAGATGTATTTATTGGAACAGCCGCAGTATCAGATTATAGAGTGCT
GAATCCTGCTTCGGAAAAAATGAAAAAAAATGAAAACTCTGAACTCACTCTCCAGCTTGTTAGAAATGCAGATATTCTTT
CTGAAGTAGCTAAAAGTGGTAAAGCTTCCTTTGTTGTTGGGTTTGCAGCTGAAACAACTGATGTGATTTCCTATGCAAAA
GAAAAAATGAAAAATAAAAAACTGGATATGATTATCGCCAATCAGGTAGGTAATGGAATGGGATTCGAAAGTGATGTAAA
TCAAGTAACAGTGATTACAAAAAACAAACAAATAGAGCTGCCATTAACCCATAAAACACGCCTGGCAGGCCAAATTATTG
CAATCCTTGCTGCAAGTCTGCAAAATTAG

Upstream 100 bases:

>100_bases
ATGGATTGATTTAAAGCTTTGCAGATCAGCATTGAGGATATTACGTAAATTTCCCAAGTGTTTGGTGAGCTCATAGGCTA
GTTGCAAACAAGATTTTTTA

Downstream 100 bases:

>100_bases
GCGCAATAAAACGATTGAGAATTATTATGCATCAAGTTATTCAGTTAAAAATTCTGGATTCAAGGATAGGAGATACCATT
CCATTGCCTGCCTATGCCAC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MLPELMKTANNSISERLCTPLVSSFSRKSSCCAVWATIILYSFYIPLLRSLCFDRGYSYQKWRSMQDFINKKILLGVCGG
IAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEVRIDLFDTQAERAMGHIELARWADYLLIAPASANCL
AKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNT
LRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHLQTFSDIEVIRVESAQS
MLEEVNRHVQQGDVFIGTAAVSDYRVLNPASEKMKKNENSELTLQLVRNADILSEVAKSGKASFVVGFAAETTDVISYAK
EKMKNKKLDMIIANQVGNGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN

Sequences:

>Translated_462_residues
MLPELMKTANNSISERLCTPLVSSFSRKSSCCAVWATIILYSFYIPLLRSLCFDRGYSYQKWRSMQDFINKKILLGVCGG
IAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEVRIDLFDTQAERAMGHIELARWADYLLIAPASANCL
AKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNT
LRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHLQTFSDIEVIRVESAQS
MLEEVNRHVQQGDVFIGTAAVSDYRVLNPASEKMKKNENSELTLQLVRNADILSEVAKSGKASFVVGFAAETTDVISYAK
EKMKNKKLDMIIANQVGNGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN
>Mature_462_residues
MLPELMKTANNSISERLCTPLVSSFSRKSSCCAVWATIILYSFYIPLLRSLCFDRGYSYQKWRSMQDFINKKILLGVCGG
IAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEVRIDLFDTQAERAMGHIELARWADYLLIAPASANCL
AKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNT
LRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHLQTFSDIEVIRVESAQS
MLEEVNRHVQQGDVFIGTAAVSDYRVLNPASEKMKKNENSELTLQLVRNADILSEVAKSGKASFVVGFAAETTDVISYAK
EKMKNKKLDMIIANQVGNGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=174, Percent_Identity=35.0574712643678, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI87082301, Length=389, Percent_Identity=50.1285347043702, Blast_Score=335, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=31.9371727748691, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=30.5699481865285, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=229, Percent_Identity=24.8908296943231, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24657262, Length=183, Percent_Identity=30.6010928961749, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 50667; Mature: 50667

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPELMKTANNSISERLCTPLVSSFSRKSSCCAVWATIILYSFYIPLLRSLCFDRGYSYQ
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KWRSMQDFINKKILLGVCGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQAL
HHHHHHHHHCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHC
SGNEVRIDLFDTQAERAMGHIELARWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTE
CCCEEEEEEECCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
TPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNT
CCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHH
LRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISG
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEC
PCHLQTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYRVLNPASEKMKKNENS
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHCCCCC
ELTLQLVRNADILSEVAKSGKASFVVGFAAETTDVISYAKEKMKNKKLDMIIANQVGNGM
CEEEEEHHCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN
CCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPELMKTANNSISERLCTPLVSSFSRKSSCCAVWATIILYSFYIPLLRSLCFDRGYSYQ
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KWRSMQDFINKKILLGVCGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQAL
HHHHHHHHHCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHC
SGNEVRIDLFDTQAERAMGHIELARWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTE
CCCEEEEEEECCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
TPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNT
CCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHH
LRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISG
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEC
PCHLQTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYRVLNPASEKMKKNENS
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHCCCCC
ELTLQLVRNADILSEVAKSGKASFVVGFAAETTDVISYAKEKMKNKKLDMIIANQVGNGM
CEEEEEHHCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN
CCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]