Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 52787420

GI number: 52787420

Start: 3560619

End: 3561260

Strand: Reverse

Name: hisG

Synonym: BLi03737

Alternate gene names: 52787420

Gene position: 3561260-3560619 (Counterclockwise)

Preceding gene: 52787421

Following gene: 52787419

Centisome position: 84.34

GC content: 49.22

Gene sequence:

>642_bases
ATGGGTAAGGAATTGACGATTGCGATGCCGAAAGGGCGGATATTTGAGGAAGCGGCCGATATGCTTCGAAAAGCAGGCTA
TCAGCTCCCGGAAGAATTCGACGATTCGAGAAAGCTGATCATTCAAGTGCCTGAAGAAAACCTTCGCTTTATCCTCGCTA
AGCCGATGGATGTCACAACATATGTCGAGCACGGGGTGGCCGATGTCGGAATCGCAGGCAAAGATGTCTTGCTAGAAGAA
GAACGAGATGTCTATGAGGTTCTTGATTTAAACATCAGCAAATGCCGTCTTGCCGTAGCCGGCCTGCCCGAGACGGCGGC
AGACACCGTTGCGCCCCGGGTTGCGACCAAGTACCCGAATGTCGCATCAAGCTACTTCAGAGAACAGGGAGAACAAGTGG
AAATCATCAAGCTCAACGGGTCGATTGAACTCGCTCCGCTGATCGGGCTTGCCGGCCGAATCGTTGATATCGTATCAACA
GGGCAGACTTTGCGTGAAAACGGGCTAGTTGAAACTGAAAAAATTTGCGACATCACATCCCGCTTAATCGTAAATCCTGT
CAGCTATCGAATGAAAGACGCAGTCATCGATGAAATGGCTTCAAGACTTTCTCTTATTGTGGAAGGAGAAAAAGCAAAAT
GA

Upstream 100 bases:

>100_bases
GTCGTCATGCAGGACTTAGCGGGAATCGGAGATATTGATCAAATGACAAAGTCTTTTCAAAACGTGACCTATTTTATCGG
AGCCAGAAAGGAAGAGAAGC

Downstream 100 bases:

>100_bases
AGATCAAATCCATCAGCGGAAATACGTCGGTTTCACTAAAACGCTCTATTGACGCCGGAACGGAGGAACAAAGAAAAGCA
GTCCGCGGCATTATCGAAGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MGKELTIAMPKGRIFEEAADMLRKAGYQLPEEFDDSRKLIIQVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVLLEE
ERDVYEVLDLNISKCRLAVAGLPETAADTVAPRVATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLAGRIVDIVST
GQTLRENGLVETEKICDITSRLIVNPVSYRMKDAVIDEMASRLSLIVEGEKAK

Sequences:

>Translated_213_residues
MGKELTIAMPKGRIFEEAADMLRKAGYQLPEEFDDSRKLIIQVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVLLEE
ERDVYEVLDLNISKCRLAVAGLPETAADTVAPRVATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLAGRIVDIVST
GQTLRENGLVETEKICDITSRLIVNPVSYRMKDAVIDEMASRLSLIVEGEKAK
>Mature_212_residues
GKELTIAMPKGRIFEEAADMLRKAGYQLPEEFDDSRKLIIQVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVLLEEE
RDVYEVLDLNISKCRLAVAGLPETAADTVAPRVATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLAGRIVDIVSTG
QTLRENGLVETEKICDITSRLIVNPVSYRMKDAVIDEMASRLSLIVEGEKAK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=224, Percent_Identity=30.3571428571429, Blast_Score=87, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=221, Percent_Identity=27.1493212669683, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_BACLD (Q65EF8)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080823.1
- RefSeq:   YP_093249.1
- ProteinModelPortal:   Q65EF8
- SMR:   Q65EF8
- STRING:   Q65EF8
- EnsemblBacteria:   EBBACT00000057388
- EnsemblBacteria:   EBBACT00000059190
- GeneID:   3028691
- GeneID:   3100934
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03737
- KEGG:   bli:BL03407
- NMPDR:   fig|279010.5.peg.3802
- eggNOG:   COG0040
- GeneTree:   EBGT00050000002951
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   BLIC279010-1:BLI03737-MONOMER
- BioCyc:   BLIC279010:BL03407-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23505; Mature: 23374

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKELTIAMPKGRIFEEAADMLRKAGYQLPEEFDDSRKLIIQVPEENLRFILAKPMDVTT
CCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCEEEEECCCCHHH
YVEHGVADVGIAGKDVLLEEERDVYEVLDLNISKCRLAVAGLPETAADTVAPRVATKYPN
HHHCCCHHCCCCCCHHEECCCCHHHHHHCCCHHHHEEEECCCCCHHHHHHCCHHHHCCCC
VASSYFREQGEQVEIIKLNGSIELAPLIGLAGRIVDIVSTGQTLRENGLVETEKICDITS
HHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
RLIVNPVSYRMKDAVIDEMASRLSLIVEGEKAK
HHHHCHHHHHHHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure 
GKELTIAMPKGRIFEEAADMLRKAGYQLPEEFDDSRKLIIQVPEENLRFILAKPMDVTT
CCCEEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCEEEEECCCCHHH
YVEHGVADVGIAGKDVLLEEERDVYEVLDLNISKCRLAVAGLPETAADTVAPRVATKYPN
HHHCCCHHCCCCCCHHEECCCCHHHHHHCCCHHHHEEEECCCCCHHHHHHCCHHHHCCCC
VASSYFREQGEQVEIIKLNGSIELAPLIGLAGRIVDIVSTGQTLRENGLVETEKICDITS
HHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
RLIVNPVSYRMKDAVIDEMASRLSLIVEGEKAK
HHHHCHHHHHHHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA