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The map label for this gene is hisD

Identifier: 52787419

GI number: 52787419

Start: 3559342

End: 3560622

Strand: Reverse

Name: hisD

Synonym: BLi03736

Alternate gene names: 52787419

Gene position: 3560622-3559342 (Counterclockwise)

Preceding gene: 52787420

Following gene: 52787418

Centisome position: 84.32

GC content: 50.66

Gene sequence:

>1281_bases
ATGAAGATCAAATCCATCAGCGGAAATACGTCGGTTTCACTAAAACGCTCTATTGACGCCGGAACGGAGGAACAAAGAAA
AGCAGTCCGCGGCATTATCGAAGAAGTGAAAAAGAACGGAAATGCAGCTGTTTCCGCATTCACAAGACAATTTGACGGAG
CGGATGTGGCCGGCTTTCGCGTTTCCGAAGAGGAAATCAAGGAAGCATACAGCGCGCTCGAAGAACGTGATCTCGAGATT
ATTCAGGCGGCGATTTTCAACATTAAAGAATATCATGAGCGTCAGCTCGCAACATCTTGGTTTTACCACCGCAAGGACGG
AACGATGCTCGGCCAAAAAATTACGCCGCTTGATTCAGCGGGGGTGTATGTGCCCGGCGGAACGGCTGCTTACCCATCAT
CCGTTCTGATGAATGTCATTCCGGCGCTTGTTGCAGGCGTCGACCGCATTGTCCTTGCCTCACCTCCGGGAAAAGACGGT
AAATTGTCGGCGGGAGTGCTGGCTGCTGCTGCGGAGCTTGGCGTCACAGAGATTTACAAAATGGGCGGTGCCCAAGCGAT
TGCCGCATTGGCTTACGGAACGGAAACGATTACCCCCGTCGATAAAATTACGGGACCCGGAAATATTTACGTCGCCTTGG
CTAAACGGGAAGTATTCGGCCAGGTTGATATCGATATGATCGCGGGTCCAAGTGAAATCGCCATACTCGCTGACAGTACG
GCAAACTACCGGGAAATCGCCGCAGATCTACTTTCACAGGCTGAACACGATGCGATGGCATCGAGCATTCTTGTCACCGA
TTCAGAGACGCTTGCCGAATCCGTTTTAAAAGAGGTTTACAGACAGCTCGAACATCTTCCGAGAAAAGAGATTGCACGGC
AGTCGATTGACAACTATGGCCTGATCTATGTTACAGAGACGATGAATGAAGCAGTTTCCGTCATCAATGAGCTCGCTCCT
GAACATTTGGAAATTTTAACAGTTCAACCCGATGCGCTGCTGGGACAGATCAAACATGCGGGCGCCATTTTCCTGGGCCG
CTACAGTTCAGAGCCGGTGGGCGATTATTTTGCAGGCCCTAATCATGTCCTGCCGACTAACGGTACAGCCAGATTTTCAA
GCCCGCTAAATGTGACAGACTTCCAAAAGCGCTCCAGCATCATTTCCTACAGCAGGGAAGCTTTCCGCGCGAATGCTGAG
AAAATTGCGGCCTTTGCCAGATTGGAAGGGCTTGAAGCCCATGCAAGAGCAATTGAATCCAGAAACCGGGAGGAAGACTG
A

Upstream 100 bases:

>100_bases
CCCGCTTAATCGTAAATCCTGTCAGCTATCGAATGAAAGACGCAGTCATCGATGAAATGGCTTCAAGACTTTCTCTTATT
GTGGAAGGAGAAAAAGCAAA

Downstream 100 bases:

>100_bases
TGAGAAAAGCCGAACGGGCAAGAAAAACCAATGAAACTGATATTAAATTATCCTTTCATATTGACGGAGAAGGAAAAGCG
GATATTCAAACGGATGTCCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKIKSISGNTSVSLKRSIDAGTEEQRKAVRGIIEEVKKNGNAAVSAFTRQFDGADVAGFRVSEEEIKEAYSALEERDLEI
IQAAIFNIKEYHERQLATSWFYHRKDGTMLGQKITPLDSAGVYVPGGTAAYPSSVLMNVIPALVAGVDRIVLASPPGKDG
KLSAGVLAAAAELGVTEIYKMGGAQAIAALAYGTETITPVDKITGPGNIYVALAKREVFGQVDIDMIAGPSEIAILADST
ANYREIAADLLSQAEHDAMASSILVTDSETLAESVLKEVYRQLEHLPRKEIARQSIDNYGLIYVTETMNEAVSVINELAP
EHLEILTVQPDALLGQIKHAGAIFLGRYSSEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKRSSIISYSREAFRANAE
KIAAFARLEGLEAHARAIESRNREED

Sequences:

>Translated_426_residues
MKIKSISGNTSVSLKRSIDAGTEEQRKAVRGIIEEVKKNGNAAVSAFTRQFDGADVAGFRVSEEEIKEAYSALEERDLEI
IQAAIFNIKEYHERQLATSWFYHRKDGTMLGQKITPLDSAGVYVPGGTAAYPSSVLMNVIPALVAGVDRIVLASPPGKDG
KLSAGVLAAAAELGVTEIYKMGGAQAIAALAYGTETITPVDKITGPGNIYVALAKREVFGQVDIDMIAGPSEIAILADST
ANYREIAADLLSQAEHDAMASSILVTDSETLAESVLKEVYRQLEHLPRKEIARQSIDNYGLIYVTETMNEAVSVINELAP
EHLEILTVQPDALLGQIKHAGAIFLGRYSSEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKRSSIISYSREAFRANAE
KIAAFARLEGLEAHARAIESRNREED
>Mature_426_residues
MKIKSISGNTSVSLKRSIDAGTEEQRKAVRGIIEEVKKNGNAAVSAFTRQFDGADVAGFRVSEEEIKEAYSALEERDLEI
IQAAIFNIKEYHERQLATSWFYHRKDGTMLGQKITPLDSAGVYVPGGTAAYPSSVLMNVIPALVAGVDRIVLASPPGKDG
KLSAGVLAAAAELGVTEIYKMGGAQAIAALAYGTETITPVDKITGPGNIYVALAKREVFGQVDIDMIAGPSEIAILADST
ANYREIAADLLSQAEHDAMASSILVTDSETLAESVLKEVYRQLEHLPRKEIARQSIDNYGLIYVTETMNEAVSVINELAP
EHLEILTVQPDALLGQIKHAGAIFLGRYSSEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKRSSIISYSREAFRANAE
KIAAFARLEGLEAHARAIESRNREED

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=411, Percent_Identity=40.8759124087591, Blast_Score=286, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=37.8896882494005, Blast_Score=255, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BACLD (Q65EF9)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080822.1
- RefSeq:   YP_093248.1
- ProteinModelPortal:   Q65EF9
- SMR:   Q65EF9
- STRING:   Q65EF9
- EnsemblBacteria:   EBBACT00000056383
- EnsemblBacteria:   EBBACT00000062370
- GeneID:   3027872
- GeneID:   3100933
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03736
- KEGG:   bli:BL03408
- NMPDR:   fig|279010.5.peg.3801
- eggNOG:   COG0141
- GeneTree:   EBGT00050000002843
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   BLIC279010-1:BLI03736-MONOMER
- BioCyc:   BLIC279010:BL03408-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46028; Mature: 46028

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 321-321 ACT_SITE 322-322 BINDING 123-123 BINDING 185-185 BINDING 208-208 BINDING 231-231 BINDING 253-253 BINDING 256-256 BINDING 322-322 BINDING 355-355 BINDING 409-409 BINDING 414-414

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKSISGNTSVSLKRSIDAGTEEQRKAVRGIIEEVKKNGNAAVSAFTRQFDGADVAGFR
CEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
VSEEEIKEAYSALEERDLEIIQAAIFNIKEYHERQLATSWFYHRKDGTMLGQKITPLDSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
GVYVPGGTAAYPSSVLMNVIPALVAGVDRIVLASPPGKDGKLSAGVLAAAAELGVTEIYK
CEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
MGGAQAIAALAYGTETITPVDKITGPGNIYVALAKREVFGQVDIDMIAGPSEIAILADST
CCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECHHHHCCCCEEEECCCCEEEEEECCC
ANYREIAADLLSQAEHDAMASSILVTDSETLAESVLKEVYRQLEHLPRKEIARQSIDNYG
CCHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
LIYVTETMNEAVSVINELAPEHLEILTVQPDALLGQIKHAGAIFLGRYSSEPVGDYFAGP
EEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
NHVLPTNGTARFSSPLNVTDFQKRSSIISYSREAFRANAEKIAAFARLEGLEAHARAIES
CCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHH
RNREED
CCCCCC
>Mature Secondary Structure
MKIKSISGNTSVSLKRSIDAGTEEQRKAVRGIIEEVKKNGNAAVSAFTRQFDGADVAGFR
CEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
VSEEEIKEAYSALEERDLEIIQAAIFNIKEYHERQLATSWFYHRKDGTMLGQKITPLDSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
GVYVPGGTAAYPSSVLMNVIPALVAGVDRIVLASPPGKDGKLSAGVLAAAAELGVTEIYK
CEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
MGGAQAIAALAYGTETITPVDKITGPGNIYVALAKREVFGQVDIDMIAGPSEIAILADST
CCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECHHHHCCCCEEEECCCCEEEEEECCC
ANYREIAADLLSQAEHDAMASSILVTDSETLAESVLKEVYRQLEHLPRKEIARQSIDNYG
CCHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
LIYVTETMNEAVSVINELAPEHLEILTVQPDALLGQIKHAGAIFLGRYSSEPVGDYFAGP
EEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
NHVLPTNGTARFSSPLNVTDFQKRSSIISYSREAFRANAEKIAAFARLEGLEAHARAIES
CCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHH
RNREED
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA