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The map label for this gene is hisB

Identifier: 52787418

GI number: 52787418

Start: 3558758

End: 3559342

Strand: Reverse

Name: hisB

Synonym: BLi03735

Alternate gene names: 52787418

Gene position: 3559342-3558758 (Counterclockwise)

Preceding gene: 52787419

Following gene: 52787417

Centisome position: 84.29

GC content: 45.81

Gene sequence:

>585_bases
ATGAGAAAAGCCGAACGGGCAAGAAAAACCAATGAAACTGATATTAAATTATCCTTTCATATTGACGGAGAAGGAAAAGC
GGATATTCAAACGGATGTCCCGTTTATGACACATATGCTTGATTTATTTACAAAACACGGGCAGTTTGACCTTTCAATTG
AAGCGAAAGGCGATGTTGAAATAGACGACCACCATACGACGGAAGATATCGGAATTTGTCTCGGACAGGCGCTTTTGGAA
GCGCTCGGAGATAAACAAGGAATCAAACGCTACGGTTCGAGCATGGTGCCGATGGATGAAGCGCTCGCCCAGGTTGCGAT
TGATCTGAGCAACAGGCCGCACCTCGAGTTCAGAGCTGAATTCCCAAGCAGGAAAATCGGAACATTTGATACAGAGCTTG
TCCATGAATTTTTGTGGAAGTTTGCACTGGAAGCGCGAATGAATCTGCATGTCATCGTTCATTACGGTACGAACACACAC
CATATGATCGAGGCCATTTTTAAAGCGCTGGGACGTGCGCTTGATGAAGCGGCATTGATCGATCCGCGGGTCAAGGGAAT
TCCATCAACGAAAGGAATGCTGTAA

Upstream 100 bases:

>100_bases
CTTTCCGCGCGAATGCTGAGAAAATTGCGGCCTTTGCCAGATTGGAAGGGCTTGAAGCCCATGCAAGAGCAATTGAATCC
AGAAACCGGGAGGAAGACTG

Downstream 100 bases:

>100_bases
ATGATCGGTGTCATAGATTACGGAATGGGAAACCTGTACAGCGTTTCTAAAGCGCTTGAACGGATTGATGCCCCTTATTT
TGTGTCCGAGCATCCGGATG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVEIDDHHTTEDIGICLGQALLE
ALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAEFPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTH
HMIEAIFKALGRALDEAALIDPRVKGIPSTKGML

Sequences:

>Translated_194_residues
MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVEIDDHHTTEDIGICLGQALLE
ALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAEFPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTH
HMIEAIFKALGRALDEAALIDPRVKGIPSTKGML
>Mature_194_residues
MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVEIDDHHTTEDIGICLGQALLE
ALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAEFPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTH
HMIEAIFKALGRALDEAALIDPRVKGIPSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=46.1538461538462, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.4495412844037, Blast_Score=148, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BACLD (Q65EG0)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080821.1
- RefSeq:   YP_093247.1
- ProteinModelPortal:   Q65EG0
- SMR:   Q65EG0
- STRING:   Q65EG0
- EnsemblBacteria:   EBBACT00000054525
- EnsemblBacteria:   EBBACT00000061226
- GeneID:   3028000
- GeneID:   3100887
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03735
- KEGG:   bli:BL03409
- NMPDR:   fig|279010.5.peg.3800
- eggNOG:   COG0131
- GeneTree:   EBGT00050000001667
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   BLIC279010-1:BLI03735-MONOMER
- BioCyc:   BLIC279010:BL03409-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21820; Mature: 21820

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVE
CCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEE
IDDHHTTEDIGICLGQALLEALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAE
ECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
FPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTHHMIEAIFKALGRALDEAALI
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
DPRVKGIPSTKGML
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVE
CCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEE
IDDHHTTEDIGICLGQALLEALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAE
ECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
FPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTHHMIEAIFKALGRALDEAALI
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
DPRVKGIPSTKGML
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA