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The map label for this gene is pdxA [H]

Identifier: 52787383

GI number: 52787383

Start: 3526829

End: 3527827

Strand: Reverse

Name: pdxA [H]

Synonym: BLi03699

Alternate gene names: 52787383

Gene position: 3527827-3526829 (Counterclockwise)

Preceding gene: 52787384

Following gene: 52787382

Centisome position: 83.55

GC content: 53.05

Gene sequence:

>999_bases
ATGAAGAAACCGGTTATCGGCATTACAATGGGCGACGCGGCAGGCGTCGGTCCGGAAATTATCGTAAAAGCCCTCACGTC
CCGCGAAGTGTATGATATGTGCAGGCCGCTCGTCATCGGCGATATGAAAATGCTGAAAAAAGCCGCCTTCCAAATCGGAT
CAGAGGTTGTTATTAACAAGGTCGGGCATCCGGACGAGGGCGGTTTTGTACATGGAAAGATCGATTGTCTCGATATTGAA
CTGCTGCCTGAAAACCTGCCTGTCGGAAAGGTGTCGGCTGAAGCTGGAAACGCCGCTTTCCATTTCGTGAAAAAAGCGGT
TGAGCTCGCTAAAAAAGGCTGTATTCAAGCGATTTGCACAGCGCCGTTAAATAAGGAGGCGCTGCATAAAGGCGGACACC
GATACCCGGGGCATACGGAAATTCTCGCTCATTTAACGAATACAACAGACTACAGCATGATGCTGGCTTCGCCAAAGCTG
AAGGTGATTCACCTGACAACGCATCAAGGGCTGATCGAGGCGATTCAGTCGATTACGCCGGAGCGGACCTATAAAGTCAT
CCGTCTCGCACATGATACATTGACAAGAGCCGGATTCGAACAGCCGAAAATTGCTGTTTGCGGAATCAACCCCCATGCAG
GGGAAAACGGCCTGTTTGGAAGCGGCGAGGAAGAACGGCAATTGCTTCCGGGGATTGAGCAGGCGGCAGCTGAGGGAATC
GATGCCGGCGGCCCATACCCCGCAGACACGCTGTTTTACAAAGCTGTCAGAGGAGATGTTGACCTTGTCGTAGCCTGCTA
CCACGACCAGGGGCATATACCGGTCAAAGTCCTCGGGTTGGAAGAGGGCGTCAACATTACAGTCGGATTAAACGGCGGGA
TCATACGCACCTCTGTCGACCACGGAACCGCATTTGACATTGCGGGGCAGAACAAAGCCGATGAAAGAAGCATGCTCGCT
GCTTTGCGGTCAGCCGCTGAGCTGGCGCCCAAATCGTAG

Upstream 100 bases:

>100_bases
AGCAGCCGGTGAAGAATTGTACATTGTGACAAAGGCCGGAAATTTTGGCTCGCGTTCGGTGATGGCAAGTGCGGCAATCA
AGCTACAAGGAGGATAAACA

Downstream 100 bases:

>100_bases
AAAAATGAAAGAAGGTTGGTGCATCTTATGAAAGTCGTATGTACATCACCGTCATTTGCGAAATACTCAGACGATCCCGT
CTTGTTTTTGGAAAAAAAGG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKKPVIGITMGDAAGVGPEIIVKALTSREVYDMCRPLVIGDMKMLKKAAFQIGSEVVINKVGHPDEGGFVHGKIDCLDIE
LLPENLPVGKVSAEAGNAAFHFVKKAVELAKKGCIQAICTAPLNKEALHKGGHRYPGHTEILAHLTNTTDYSMMLASPKL
KVIHLTTHQGLIEAIQSITPERTYKVIRLAHDTLTRAGFEQPKIAVCGINPHAGENGLFGSGEEERQLLPGIEQAAAEGI
DAGGPYPADTLFYKAVRGDVDLVVACYHDQGHIPVKVLGLEEGVNITVGLNGGIIRTSVDHGTAFDIAGQNKADERSMLA
ALRSAAELAPKS

Sequences:

>Translated_332_residues
MKKPVIGITMGDAAGVGPEIIVKALTSREVYDMCRPLVIGDMKMLKKAAFQIGSEVVINKVGHPDEGGFVHGKIDCLDIE
LLPENLPVGKVSAEAGNAAFHFVKKAVELAKKGCIQAICTAPLNKEALHKGGHRYPGHTEILAHLTNTTDYSMMLASPKL
KVIHLTTHQGLIEAIQSITPERTYKVIRLAHDTLTRAGFEQPKIAVCGINPHAGENGLFGSGEEERQLLPGIEQAAAEGI
DAGGPYPADTLFYKAVRGDVDLVVACYHDQGHIPVKVLGLEEGVNITVGLNGGIIRTSVDHGTAFDIAGQNKADERSMLA
ALRSAAELAPKS
>Mature_332_residues
MKKPVIGITMGDAAGVGPEIIVKALTSREVYDMCRPLVIGDMKMLKKAAFQIGSEVVINKVGHPDEGGFVHGKIDCLDIE
LLPENLPVGKVSAEAGNAAFHFVKKAVELAKKGCIQAICTAPLNKEALHKGGHRYPGHTEILAHLTNTTDYSMMLASPKL
KVIHLTTHQGLIEAIQSITPERTYKVIRLAHDTLTRAGFEQPKIAVCGINPHAGENGLFGSGEEERQLLPGIEQAAAEGI
DAGGPYPADTLFYKAVRGDVDLVVACYHDQGHIPVKVLGLEEGVNITVGLNGGIIRTSVDHGTAFDIAGQNKADERSMLA
ALRSAAELAPKS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=335, Percent_Identity=37.0149253731343, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35340; Mature: 35340

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPVIGITMGDAAGVGPEIIVKALTSREVYDMCRPLVIGDMKMLKKAAFQIGSEVVINK
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
VGHPDEGGFVHGKIDCLDIELLPENLPVGKVSAEAGNAAFHFVKKAVELAKKGCIQAICT
CCCCCCCCEEEEEEEEEEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
APLNKEALHKGGHRYPGHTEILAHLTNTTDYSMMLASPKLKVIHLTTHQGLIEAIQSITP
CCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEECHHHHHHHHHHCCC
ERTYKVIRLAHDTLTRAGFEQPKIAVCGINPHAGENGLFGSGEEERQLLPGIEQAAAEGI
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHCCC
DAGGPYPADTLFYKAVRGDVDLVVACYHDQGHIPVKVLGLEEGVNITVGLNGGIIRTSVD
CCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEEECC
HGTAFDIAGQNKADERSMLAALRSAAELAPKS
CCCEEEECCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKPVIGITMGDAAGVGPEIIVKALTSREVYDMCRPLVIGDMKMLKKAAFQIGSEVVINK
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
VGHPDEGGFVHGKIDCLDIELLPENLPVGKVSAEAGNAAFHFVKKAVELAKKGCIQAICT
CCCCCCCCEEEEEEEEEEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
APLNKEALHKGGHRYPGHTEILAHLTNTTDYSMMLASPKLKVIHLTTHQGLIEAIQSITP
CCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEECHHHHHHHHHHCCC
ERTYKVIRLAHDTLTRAGFEQPKIAVCGINPHAGENGLFGSGEEERQLLPGIEQAAAEGI
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHCCC
DAGGPYPADTLFYKAVRGDVDLVVACYHDQGHIPVKVLGLEEGVNITVGLNGGIIRTSVD
CCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEEECC
HGTAFDIAGQNKADERSMLAALRSAAELAPKS
CCCEEEECCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]