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The map label for this gene is serA [H]

Identifier: 52787382

GI number: 52787382

Start: 3525851

End: 3526801

Strand: Reverse

Name: serA [H]

Synonym: BLi03698

Alternate gene names: 52787382

Gene position: 3526801-3525851 (Counterclockwise)

Preceding gene: 52787383

Following gene: 52787381

Centisome position: 83.52

GC content: 49.95

Gene sequence:

>951_bases
ATGAAAGTCGTATGTACATCACCGTCATTTGCGAAATACTCAGACGATCCCGTCTTGTTTTTGGAAAAAAAGGGCATGTC
GCTGGAACGCCTTCCTGCAGATATAACCGAGGAGCAGTTTATTGAAGCAGCAGAAGGAGCGGATGCCGCGATCGTGGCGT
TTAACCAGATTACGCCGTATGTCCTGGATCGTCTCCCTTCTTTAAAAATTGTCTGCAAACATGGCGTCGGTGTCGACAAT
ATCGATCTGCACGCTGCGAAAGAGCGCAACGTCTGGGTGACGAATGCCCCCAACGCCAACAAGCATGCAGTCGCCGATTT
TGTATTCGGTCTCATGCTGTCGGCTGCAAGACAGATTCCTGCAGCCGACAGGGAGACAAAGCTGGGAAAATGGCCGAGGA
TTTTTGGATCTGACGTTTACGGCAAAACACTCGGCATCGTCGGACTTGGCATGATCGGAAAAGAAGTCGCCAAACGGGCG
CAAGGCTTCAATATGACTGTTTTAGCCTATGATGTGTTTCCTGATCGTGCATTCGCAGCCGATCATCACATCCATTTTAC
AGAGCTTGATCAGCTCTTGAAAGAATGCGACTTTATCACTCTTCATATGCCGCTCACAGCCGAAACGGAAAACATGATCG
GTGAAAAAGAATTAGCCGCTATGAAAGAAACGGCTTATCTGATCAATGCTTCAAGGGGAGGCATCGTGTCCGAGTGTGCG
TTATATGATGCCTTGGCGAGCGGGGGCATCGCTGGAGCTGCGCTTGACGTGTATCAAACCGAACCGCTGAAGCAGCACCC
TCTCTTTGAGCTGGACCGTTTTATCGCCGTGCCGCATATCGCGGGGTATACCCGAGATGCCGTACAGAACCTTGGCATGA
TATGCGTCAAAAACATCGCTAGTGTACTGATCGACAAACAAAAACCGGAGTTTGTCGTCAACGGGTTGTGA

Upstream 100 bases:

>100_bases
GCAGAACAAAGCCGATGAAAGAAGCATGCTCGCTGCTTTGCGGTCAGCCGCTGAGCTGGCGCCCAAATCGTAGAAAAATG
AAAGAAGGTTGGTGCATCTT

Downstream 100 bases:

>100_bases
ATGTGTTTTCATTCATGCCCTGCATCATGATTTGAAAGCGTTTTCTACAAATGGGATGAGGTGGATAACATGTTGAATCA
CCCGATTCAAAAAAAGTCAA

Product: hypothetical protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKVVCTSPSFAKYSDDPVLFLEKKGMSLERLPADITEEQFIEAAEGADAAIVAFNQITPYVLDRLPSLKIVCKHGVGVDN
IDLHAAKERNVWVTNAPNANKHAVADFVFGLMLSAARQIPAADRETKLGKWPRIFGSDVYGKTLGIVGLGMIGKEVAKRA
QGFNMTVLAYDVFPDRAFAADHHIHFTELDQLLKECDFITLHMPLTAETENMIGEKELAAMKETAYLINASRGGIVSECA
LYDALASGGIAGAALDVYQTEPLKQHPLFELDRFIAVPHIAGYTRDAVQNLGMICVKNIASVLIDKQKPEFVVNGL

Sequences:

>Translated_316_residues
MKVVCTSPSFAKYSDDPVLFLEKKGMSLERLPADITEEQFIEAAEGADAAIVAFNQITPYVLDRLPSLKIVCKHGVGVDN
IDLHAAKERNVWVTNAPNANKHAVADFVFGLMLSAARQIPAADRETKLGKWPRIFGSDVYGKTLGIVGLGMIGKEVAKRA
QGFNMTVLAYDVFPDRAFAADHHIHFTELDQLLKECDFITLHMPLTAETENMIGEKELAAMKETAYLINASRGGIVSECA
LYDALASGGIAGAALDVYQTEPLKQHPLFELDRFIAVPHIAGYTRDAVQNLGMICVKNIASVLIDKQKPEFVVNGL
>Mature_316_residues
MKVVCTSPSFAKYSDDPVLFLEKKGMSLERLPADITEEQFIEAAEGADAAIVAFNQITPYVLDRLPSLKIVCKHGVGVDN
IDLHAAKERNVWVTNAPNANKHAVADFVFGLMLSAARQIPAADRETKLGKWPRIFGSDVYGKTLGIVGLGMIGKEVAKRA
QGFNMTVLAYDVFPDRAFAADHHIHFTELDQLLKECDFITLHMPLTAETENMIGEKELAAMKETAYLINASRGGIVSECA
LYDALASGGIAGAALDVYQTEPLKQHPLFELDRFIAVPHIAGYTRDAVQNLGMICVKNIASVLIDKQKPEFVVNGL

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=278, Percent_Identity=36.6906474820144, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=33.2, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI61743967, Length=241, Percent_Identity=34.8547717842324, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4557497, Length=241, Percent_Identity=34.8547717842324, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=33.1932773109244, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=33.1932773109244, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=33.1932773109244, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=36.4341085271318, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789279, Length=280, Percent_Identity=33.9285714285714, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=32, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87081824, Length=146, Percent_Identity=33.5616438356164, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788660, Length=222, Percent_Identity=31.981981981982, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=222, Percent_Identity=41.4414414414414, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=264, Percent_Identity=31.0606060606061, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=292, Percent_Identity=34.5890410958904, Blast_Score=166, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322116, Length=292, Percent_Identity=33.5616438356164, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=295, Percent_Identity=27.7966101694915, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=328, Percent_Identity=27.4390243902439, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=181, Percent_Identity=31.4917127071823, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=26, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=280, Percent_Identity=37.5, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=28.673835125448, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574286, Length=271, Percent_Identity=32.4723247232472, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=309, Percent_Identity=27.831715210356, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574282, Length=309, Percent_Identity=27.831715210356, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551003, Length=308, Percent_Identity=27.9220779220779, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574284, Length=309, Percent_Identity=27.831715210356, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552429, Length=308, Percent_Identity=27.9220779220779, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571528, Length=281, Percent_Identity=31.3167259786477, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=32.5581395348837, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34532; Mature: 34532

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVCTSPSFAKYSDDPVLFLEKKGMSLERLPADITEEQFIEAAEGADAAIVAFNQITPY
CEEEECCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCHH
VLDRLPSLKIVCKHGVGVDNIDLHAAKERNVWVTNAPNANKHAVADFVFGLMLSAARQIP
HHHCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
AADRETKLGKWPRIFGSDVYGKTLGIVGLGMIGKEVAKRAQGFNMTVLAYDVFPDRAFAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
DHHIHFTELDQLLKECDFITLHMPLTAETENMIGEKELAAMKETAYLINASRGGIVSECA
CCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHCCHHHHHHHHHHHEEEECCCCCHHHHHH
LYDALASGGIAGAALDVYQTEPLKQHPLFELDRFIAVPHIAGYTRDAVQNLGMICVKNIA
HHHHHHCCCCCHHEEEHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
SVLIDKQKPEFVVNGL
HHHHCCCCCCEEECCC
>Mature Secondary Structure
MKVVCTSPSFAKYSDDPVLFLEKKGMSLERLPADITEEQFIEAAEGADAAIVAFNQITPY
CEEEECCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCHH
VLDRLPSLKIVCKHGVGVDNIDLHAAKERNVWVTNAPNANKHAVADFVFGLMLSAARQIP
HHHCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
AADRETKLGKWPRIFGSDVYGKTLGIVGLGMIGKEVAKRAQGFNMTVLAYDVFPDRAFAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
DHHIHFTELDQLLKECDFITLHMPLTAETENMIGEKELAAMKETAYLINASRGGIVSECA
CCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHCCHHHHHHHHHHHEEEECCCCCHHHHHH
LYDALASGGIAGAALDVYQTEPLKQHPLFELDRFIAVPHIAGYTRDAVQNLGMICVKNIA
HHHHHHCCCCCHHEEEHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
SVLIDKQKPEFVVNGL
HHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]