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The map label for this gene is hemD [H]

Identifier: 52786676

GI number: 52786676

Start: 2828933

End: 2829724

Strand: Reverse

Name: hemD [H]

Synonym: BLi02944

Alternate gene names: 52786676

Gene position: 2829724-2828933 (Counterclockwise)

Preceding gene: 52786677

Following gene: 52786675

Centisome position: 67.01

GC content: 48.86

Gene sequence:

>792_bases
ATGAAGCATGATCTTCCTTTAGAGGGAAAGAAAGTGCTCGTCACCCGCAATAAAGCGCAAGCCCAATCTTTCAGGGAAAA
GGTGGAGGCTTTGGGCGGGGAAGCTGTTTTAACGTCATTGATTTCGTTTCGGCCCGCCCTTCCGCCAGAACAGGCCCGGC
GCTTTCGAGCAGATCTTGAAAGTGCGGACTGGCTTGTTTTTACAAGCGTGAACGGGGCAAAATTCTTTTTTTCTTATTTA
AAGGACGCCGGGTTGTGCGATCCTCCCGCATCAAAGGCGAAGGTTGCTGCTGTCGGTGAAAAAACAGCCCGGTATTTGCG
CGACAGGGGTCTTTCTGTCGATCTGATGCCGGAGTTATACGTGGCTGAACATTTGGCGGAGGCACTTAAGCAAAATGCCG
GACGTCATGACAAAGTGGTCGTTTTAAAAGGGAATTTATCCCGGGACGTCATCAAGAAAACCATCTCTCCTCTCGGAATT
CAAGTTTCGGAATGGATTTTGTATGAAACCGTGCGTGATGAAAGGGGAATTCTGGACCTGAAGGAAGCAGCAAAGCACGC
GTCTTTTGATTTTGTGACGTTTACCAGTTCTTCGACGGTACATACATTCATGTCCATTCTGAAAGAGGAGAGCTTAGCGT
GGGCCGAAAAGAACCGGACGGCTTTTATTACGATCGGGCCTTTGACAAAGAAGGCGCTGTCGGACTACGGAATTCCATCA
TATATGCCGGACGTCTATACAATCGACGGAATGCTGCGCGAAATGTGCCGCATTTCAAGAAAGGGAGAATGA

Upstream 100 bases:

>100_bases
GGAAAAGATCCGGAGGCTGTCGGCAGAGAATGCGCCGCAGTCATGTCGGAAAAAGGAGCAAAGGCACTGATTGACCGGGT
GAAACAGGAGCTGGAAGACC

Downstream 100 bases:

>100_bases
CTAATGGAAGCATCATTTCAAAGACACCGCCGCCTGCGGACGACAGCAGGTATGCGGAAATTGGTAAGGGAAACCGAGTT
AAGAGCATCTGATTTCATTT

Product: hypothetical protein

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKHDLPLEGKKVLVTRNKAQAQSFREKVEALGGEAVLTSLISFRPALPPEQARRFRADLESADWLVFTSVNGAKFFFSYL
KDAGLCDPPASKAKVAAVGEKTARYLRDRGLSVDLMPELYVAEHLAEALKQNAGRHDKVVVLKGNLSRDVIKKTISPLGI
QVSEWILYETVRDERGILDLKEAAKHASFDFVTFTSSSTVHTFMSILKEESLAWAEKNRTAFITIGPLTKKALSDYGIPS
YMPDVYTIDGMLREMCRISRKGE

Sequences:

>Translated_263_residues
MKHDLPLEGKKVLVTRNKAQAQSFREKVEALGGEAVLTSLISFRPALPPEQARRFRADLESADWLVFTSVNGAKFFFSYL
KDAGLCDPPASKAKVAAVGEKTARYLRDRGLSVDLMPELYVAEHLAEALKQNAGRHDKVVVLKGNLSRDVIKKTISPLGI
QVSEWILYETVRDERGILDLKEAAKHASFDFVTFTSSSTVHTFMSILKEESLAWAEKNRTAFITIGPLTKKALSDYGIPS
YMPDVYTIDGMLREMCRISRKGE
>Mature_263_residues
MKHDLPLEGKKVLVTRNKAQAQSFREKVEALGGEAVLTSLISFRPALPPEQARRFRADLESADWLVFTSVNGAKFFFSYL
KDAGLCDPPASKAKVAAVGEKTARYLRDRGLSVDLMPELYVAEHLAEALKQNAGRHDKVVVLKGNLSRDVIKKTISPLGI
QVSEWILYETVRDERGILDLKEAAKHASFDFVTFTSSSTVHTFMSILKEESLAWAEKNRTAFITIGPLTKKALSDYGIPS
YMPDVYTIDGMLREMCRISRKGE

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29369; Mature: 29369

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHDLPLEGKKVLVTRNKAQAQSFREKVEALGGEAVLTSLISFRPALPPEQARRFRADLE
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC
SADWLVFTSVNGAKFFFSYLKDAGLCDPPASKAKVAAVGEKTARYLRDRGLSVDLMPELY
CCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHH
VAEHLAEALKQNAGRHDKVVVLKGNLSRDVIKKTISPLGIQVSEWILYETVRDERGILDL
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCH
KEAAKHASFDFVTFTSSSTVHTFMSILKEESLAWAEKNRTAFITIGPLTKKALSDYGIPS
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
YMPDVYTIDGMLREMCRISRKGE
CCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKHDLPLEGKKVLVTRNKAQAQSFREKVEALGGEAVLTSLISFRPALPPEQARRFRADLE
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC
SADWLVFTSVNGAKFFFSYLKDAGLCDPPASKAKVAAVGEKTARYLRDRGLSVDLMPELY
CCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHH
VAEHLAEALKQNAGRHDKVVVLKGNLSRDVIKKTISPLGIQVSEWILYETVRDERGILDL
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCH
KEAAKHASFDFVTFTSSSTVHTFMSILKEESLAWAEKNRTAFITIGPLTKKALSDYGIPS
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
YMPDVYTIDGMLREMCRISRKGE
CCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]