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The map label for this gene is nadC [H]

Identifier: 52786645

GI number: 52786645

Start: 2800201

End: 2801040

Strand: Reverse

Name: nadC [H]

Synonym: BLi02913

Alternate gene names: 52786645

Gene position: 2801040-2800201 (Counterclockwise)

Preceding gene: 52786646

Following gene: 52786644

Centisome position: 66.33

GC content: 49.64

Gene sequence:

>840_bases
ATGCAGCGGTTCATACTTAGGAACATGCTTAAGGAATTTTTCAAGGAAGATATCGGCCGGGGGGATCTCACTTCAGAAGC
CGTTTTTGATGACAATCATCAATGCGAAGCTGTCATCACAGCGAAGGATGACGGCTTGTTTGCAGGAGAATTAGTGATTC
TGGAAGGCTTTCGGCTGCTTGATGAAACGATCGCCGTCCACATGCTGAAAACAGATGGCGAAGCGGTTCGTAAAGGGGAA
ACGATCGCGCGACTCAAAGGCCGTGCAGCTTCCCTCATGACCGGTGAACGGGTTGTGCTGAATCTCATTCAAAGAATGTC
CGGGATCGCCACATTAACAAAGCAGTCCATTATCAGGCTGAATGATCCGAATATCGCGATTTGCGATACGAGAAAGACGA
CCCCGGGCCTGCGCATCCTTGAAAAATACGCGGTCAAAACCGGCGGGGGCAGCAATCACCGCTTTGGATTGGACGGCGGC
ATCATGATTAAAGACAACCATATTGCCGCCTGCGGCTCGATTTCAAAAGCGGTTGAAAAAGCGCGGTCAGCGTGCGGCCA
TATGGTCAAGATCGAAGTGGAGATCGAATCTGAACAAGAGCTTCATGAAGCGATTGAGGCCGGCGCCGATATCATTATGT
TCGACAATTGCCCGCCCGAGACGGTGAAAGCATTTGCTGAAATGACACCCGCCGGCATTATAACGGAGGCTTCAGGCGGA
ATTTCATTTGAAAATCTCCCCGCTTACAGGGGAACAGGGGTGCACTGTATTTCATTGGGCTACTTGACTCATTCGGCGAA
AAGCCTTGATATCAGCATGAATGTTGATCTGAAAAAATAA

Upstream 100 bases:

>100_bases
TCGGATTGTCCGGCGCCTGATGATAAAAACTGGCACGGCAAGCAAATCGTTCACACAAAAGGCGGGATCAAGATCAGACA
AAACGAAGGGATTGTGAAAT

Downstream 100 bases:

>100_bases
GCGGGATTGGAGAGGGTACAGATGTCTATTTTAAAAGTGATTCATGACAGGAACGCCGGCATGATGCCGGAGGTGTATAA
AGAATTGACTGAGGAAGAAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLLDETIAVHMLKTDGEAVRKGE
TIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRLNDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGG
IMIKDNHIAACGSISKAVEKARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEASGG
ISFENLPAYRGTGVHCISLGYLTHSAKSLDISMNVDLKK

Sequences:

>Translated_279_residues
MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLLDETIAVHMLKTDGEAVRKGE
TIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRLNDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGG
IMIKDNHIAACGSISKAVEKARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEASGG
ISFENLPAYRGTGVHCISLGYLTHSAKSLDISMNVDLKK
>Mature_279_residues
MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLLDETIAVHMLKTDGEAVRKGE
TIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRLNDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGG
IMIKDNHIAACGSISKAVEKARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEASGG
ISFENLPAYRGTGVHCISLGYLTHSAKSLDISMNVDLKK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=35.1254480286738, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI1786299, Length=268, Percent_Identity=38.8059701492537, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=284, Percent_Identity=35.2112676056338, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30348; Mature: 30348

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLL
CCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEEECCCCEEECEEEEEHHHHHH
DETIAVHMLKTDGEAVRKGETIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRL
HHHHEEEEEECCCHHHHCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEE
NDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGGIMIKDNHIAACGSISKAVEK
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCEEEHHHHHHHHHH
ARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEASGG
HHHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCC
ISFENLPAYRGTGVHCISLGYLTHSAKSLDISMNVDLKK
CCCCCCCCCCCCCEEEEEEEEHHCCCCEEEEEEEEEECC
>Mature Secondary Structure
MQRFILRNMLKEFFKEDIGRGDLTSEAVFDDNHQCEAVITAKDDGLFAGELVILEGFRLL
CCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEEECCCCEEECEEEEEHHHHHH
DETIAVHMLKTDGEAVRKGETIARLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRL
HHHHEEEEEECCCHHHHCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEE
NDPNIAICDTRKTTPGLRILEKYAVKTGGGSNHRFGLDGGIMIKDNHIAACGSISKAVEK
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCEEEHHHHHHHHHH
ARSACGHMVKIEVEIESEQELHEAIEAGADIIMFDNCPPETVKAFAEMTPAGIITEASGG
HHHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCC
ISFENLPAYRGTGVHCISLGYLTHSAKSLDISMNVDLKK
CCCCCCCCCCCCCEEEEEEEEHHCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]