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The map label for this gene is nadA

Identifier: 52786644

GI number: 52786644

Start: 2799070

End: 2800179

Strand: Reverse

Name: nadA

Synonym: BLi02912

Alternate gene names: 52786644

Gene position: 2800179-2799070 (Counterclockwise)

Preceding gene: 52786645

Following gene: 52786643

Centisome position: 66.31

GC content: 46.67

Gene sequence:

>1110_bases
ATGTCTATTTTAAAAGTGATTCATGACAGGAACGCCGGCATGATGCCGGAGGTGTATAAAGAATTGACTGAGGAAGAAAT
GGCCGGAAGGATTTTGAAAATCAAAAAGAAATTCGGAGCAAGGCTGTTTATCCCGGGGCATCACTACCAAAAAGACGAAG
TGATTCAATTTGCGGACGCGACGGGCGATTCGCTCCAGCTGGCACAGGTCGCCCAAAAAAATAAAAAAGCGGAATATATC
GTGTTCTGCGGCGTACATTTTATGGCGGAAACAGCCGATATGCTCACTTCGGACGAACAGATTGTCGTTTTGCCGGACAT
GCGCGCAGGCTGTTCGATGGCCGATATGGCCAATATGCGGCAGACAAATCGCGCCTGGGAAGAGCTGACGAAGCTGTTTG
GCGATACGGTCATTCCGCTCACATATGTCAATTCGACAGCTGAAATTAAGGCTTTTGTGGGAAGAAACGGAGGAGCGTCC
GTGACATCCTCAAATGCGGCGCGCATGTTGACATGGGCGCTATCGCAAAAGGAGAGGATTTTATTTCTTCCGGATCAGCA
CTTGGGACGCAACACGGCATTTGACCTCGGCATTCCTCTAAGCAGGATGGCGGTATGGGATCCAATTGCAGAAAAACTTG
AGTATAACGGCGATATGAAAGACATAATAATCATTTTGTGGAAGGGGCATTGTTCAGTTCACGAAAAATTTACCGTGGCG
AATATCAAAAGTGTTAAAGAGCGGGATCCGGACATCAATGTTATCGTTCATCCGGAATGCACCCACGAAGTCGTTGCGCT
CAGCGATTTCAGCGGATCTACAAAAAAAATCATCGACTCCATTAATGAAGCAAAACCGGGGAGCAAATGGGCGATTGGAA
CAGAGATGAACCTTGTTTCACGCATCATTCAAGAACATCCTGATAAACAAATCGAATCCCTTAACCCTGATATGTGTCCT
TGTTTGACAATGAACAGAATCGACATGCCGCATTTGCTGTGGTCGCTGGAGCAGATCGACAAAGGTGAACCGACAGGCGT
GATCAAAGTGGATCAAGATATTGCAAAAGATGCCATTCTTGCGCTGAATCGGATGTTAACGATCCGTTAA

Upstream 100 bases:

>100_bases
GCACTGTATTTCATTGGGCTACTTGACTCATTCGGCGAAAAGCCTTGATATCAGCATGAATGTTGATCTGAAAAAATAAG
CGGGATTGGAGAGGGTACAG

Downstream 100 bases:

>100_bases
CTTTTTGGAGAACAAGTTTTTATCATAACCCCTCCGCTATGCGCATAAATTTGTGGAGAAGCATATTTGTTATTCTCATC
TGTTCGTTCACGTTTTTGCA

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSILKVIHDRNAGMMPEVYKELTEEEMAGRILKIKKKFGARLFIPGHHYQKDEVIQFADATGDSLQLAQVAQKNKKAEYI
VFCGVHFMAETADMLTSDEQIVVLPDMRAGCSMADMANMRQTNRAWEELTKLFGDTVIPLTYVNSTAEIKAFVGRNGGAS
VTSSNAARMLTWALSQKERILFLPDQHLGRNTAFDLGIPLSRMAVWDPIAEKLEYNGDMKDIIIILWKGHCSVHEKFTVA
NIKSVKERDPDINVIVHPECTHEVVALSDFSGSTKKIIDSINEAKPGSKWAIGTEMNLVSRIIQEHPDKQIESLNPDMCP
CLTMNRIDMPHLLWSLEQIDKGEPTGVIKVDQDIAKDAILALNRMLTIR

Sequences:

>Translated_369_residues
MSILKVIHDRNAGMMPEVYKELTEEEMAGRILKIKKKFGARLFIPGHHYQKDEVIQFADATGDSLQLAQVAQKNKKAEYI
VFCGVHFMAETADMLTSDEQIVVLPDMRAGCSMADMANMRQTNRAWEELTKLFGDTVIPLTYVNSTAEIKAFVGRNGGAS
VTSSNAARMLTWALSQKERILFLPDQHLGRNTAFDLGIPLSRMAVWDPIAEKLEYNGDMKDIIIILWKGHCSVHEKFTVA
NIKSVKERDPDINVIVHPECTHEVVALSDFSGSTKKIIDSINEAKPGSKWAIGTEMNLVSRIIQEHPDKQIESLNPDMCP
CLTMNRIDMPHLLWSLEQIDKGEPTGVIKVDQDIAKDAILALNRMLTIR
>Mature_368_residues
SILKVIHDRNAGMMPEVYKELTEEEMAGRILKIKKKFGARLFIPGHHYQKDEVIQFADATGDSLQLAQVAQKNKKAEYIV
FCGVHFMAETADMLTSDEQIVVLPDMRAGCSMADMANMRQTNRAWEELTKLFGDTVIPLTYVNSTAEIKAFVGRNGGASV
TSSNAARMLTWALSQKERILFLPDQHLGRNTAFDLGIPLSRMAVWDPIAEKLEYNGDMKDIIIILWKGHCSVHEKFTVAN
IKSVKERDPDINVIVHPECTHEVVALSDFSGSTKKIIDSINEAKPGSKWAIGTEMNLVSRIIQEHPDKQIESLNPDMCPC
LTMNRIDMPHLLWSLEQIDKGEPTGVIKVDQDIAKDAILALNRMLTIR

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 3 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=380, Percent_Identity=27.1052631578947, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_BACLD (Q65GN4)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080056.1
- RefSeq:   YP_092473.1
- HSSP:   O57767
- ProteinModelPortal:   Q65GN4
- SMR:   Q65GN4
- STRING:   Q65GN4
- EnsemblBacteria:   EBBACT00000054626
- EnsemblBacteria:   EBBACT00000060270
- GeneID:   3028013
- GeneID:   3098281
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02912
- KEGG:   bli:BL01153
- NMPDR:   fig|279010.5.peg.3239
- eggNOG:   COG0379
- GeneTree:   EBGT00050000002444
- HOGENOM:   HBG291157
- OMA:   GTELNLV
- ProtClustDB:   PRK09375
- BioCyc:   BLIC279010-1:BLI02912-MONOMER
- BioCyc:   BLIC279010:BL01153-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00569
- InterPro:   IPR003473
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 41417; Mature: 41286

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: BINDING 47-47 BINDING 64-64 BINDING 142-142 BINDING 163-163 BINDING 257-257 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILKVIHDRNAGMMPEVYKELTEEEMAGRILKIKKKFGARLFIPGHHYQKDEVIQFADA
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHEEEECC
TGDSLQLAQVAQKNKKAEYIVFCGVHFMAETADMLTSDEQIVVLPDMRAGCSMADMANMR
CCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
QTNRAWEELTKLFGDTVIPLTYVNSTAEIKAFVGRNGGASVTSSNAARMLTWALSQKERI
HHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHEECCCCCEE
LFLPDQHLGRNTAFDLGIPLSRMAVWDPIAEKLEYNGDMKDIIIILWKGHCSVHEKFTVA
EECCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEHH
NIKSVKERDPDINVIVHPECTHEVVALSDFSGSTKKIIDSINEAKPGSKWAIGTEMNLVS
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHH
RIIQEHPDKQIESLNPDMCPCLTMNRIDMPHLLWSLEQIDKGEPTGVIKVDQDIAKDAIL
HHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHH
ALNRMLTIR
HHHHHHCCC
>Mature Secondary Structure 
SILKVIHDRNAGMMPEVYKELTEEEMAGRILKIKKKFGARLFIPGHHYQKDEVIQFADA
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHEEEECC
TGDSLQLAQVAQKNKKAEYIVFCGVHFMAETADMLTSDEQIVVLPDMRAGCSMADMANMR
CCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
QTNRAWEELTKLFGDTVIPLTYVNSTAEIKAFVGRNGGASVTSSNAARMLTWALSQKERI
HHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHEECCCCCEE
LFLPDQHLGRNTAFDLGIPLSRMAVWDPIAEKLEYNGDMKDIIIILWKGHCSVHEKFTVA
EECCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEHH
NIKSVKERDPDINVIVHPECTHEVVALSDFSGSTKKIIDSINEAKPGSKWAIGTEMNLVS
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHH
RIIQEHPDKQIESLNPDMCPCLTMNRIDMPHLLWSLEQIDKGEPTGVIKVDQDIAKDAIL
HHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHH
ALNRMLTIR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA