Click here to switch to the map view.

The map label for this gene is gcvPA

Identifier: 52786368

GI number: 52786368

Start: 2544602

End: 2545948

Strand: Reverse

Name: gcvPA

Synonym: BLi02630

Alternate gene names: 52786368

Gene position: 2545948-2544602 (Counterclockwise)

Preceding gene: 52786369

Following gene: 52786367

Centisome position: 60.29

GC content: 49.89

Gene sequence:

>1347_bases
ATGAAGCACCGTTACCTGCCAGCTACAGATCAGGATAAAAAGGAGATGCTTGAGGCAATTGGAGTCGAGAGAATCGACGA
GCTATTCTCCGATATACCCGAAAGCGTCAGATTTAAAGGGGAATACCAAATTAAAAAGGCAAAGTCCGAGACGGAGCTTA
CAAAAGAGCTGACGAAACTCGCGGCTAAAAATAAAGATACAGTGACGTACGCCTCTTTTTTGGGAGCGGGCGTATACGAT
CATTACCAGCCCGTCATCGTGGATCACGTGATTTCGCGGTCGGAATTTTACACGGCCTACACACCGTATCAGCCAGAAAT
TTCTCAAGGGGAGCTCCAGGCGATTTTCGAATTTCAAACGATGATTTGCGAGCTGACGGGCATGGATATCAGCAACTCGT
CGATGTATGACGGAGGAACGGCGTTAGCCGAAGCGGCAATGCTTGCTTCAGGACATACAAAAAAGAAAAAAATCGTCGTT
TCGGAAACCGTCCATCCCGAATCGCGCGAGGTTCTAAAAACGTATGCGAAAGGACAGTACATCGATGTGGTAGAAGTCCC
TTCCAAAAACGGAACAGCGGATCTTGAGGCTCTTGATGAAGCCGTCTGCGAAGATACAGCAGCAGTGATCGTCCAATATC
CCAACTTTTTCGGGCGAATTGAGCCGCTGAAAGACATTAAACCGATCGCCCATAAAGGGAAAAGCATGTTCATCGTTTCC
GCCAATCCGCTGGCTCTCGGGCTTTTAACACCGCCCGGGGCGTTGGGCGCTGACATCGTTGTCGGAGATGCCCAGCCGTT
CGGAATCCCTGCTGCTTTCGGCGGTCCGCACTGCGGATTCTTTGCCGTCACGAAAAAATTGATGAGAAAAGTGCCTGGCC
GTCTAGTCGGTCAGACGGAAGATGAAAACGGGAAAAGGGGATTCGTTCTCACCCTGCAGGCCCGCGAGCAGCATATCAGA
CGGGATAAAGCAACATCAAATATATGCTCCAACCAGGCGCTCAACGCGCTTGCTGCGTCAGTCGCCATGACGGCGCTCGG
AAAAAAAGGCGTCAAGGAAATCGCATGGCAGAACCTGCAAAAAGCGGCTTACGCAAAAGAAGCAGCTAAACGGGCCGGTC
TTGAAGTCGCGTTTGAGGGGCCGATGTTCAACGAGTTTGTCATCAGACTCAATGAACCTGTCGAAAAAGCGAATGAACGC
CTGCTTGAGAAAAATATTATCGGAGGCTACGATCTCGGCGCTTCATATCCGGATTTAAAACGGCACATGCTGATCGCCGT
GACAGAGCTCAGAACAAAAGAGGAAATCGATACACTCATGAATGAATTGGGGGATTGCCATGAATAA

Upstream 100 bases:

>100_bases
AGTGGAGATCAGAAATAAACGTTTGAAAGCCAAAATCGTGAAAACCCCATTTTACAAACGGCAGCCGTAAGTTTGCCAAG
ACCTTGAAAGGAGACTGAAG

Downstream 100 bases:

>100_bases
TCAGGATCAATCGCTTATTTTTGAAGTATCAAAAGAAGGGCGGGTCGGCTACAGCCTTCCTGAGCTTGACGTCCCTGAAA
CAGATGTGACAGACGTCATT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKHRYLPATDQDKKEMLEAIGVERIDELFSDIPESVRFKGEYQIKKAKSETELTKELTKLAAKNKDTVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDISNSSMYDGGTALAEAAMLASGHTKKKKIVV
SETVHPESREVLKTYAKGQYIDVVEVPSKNGTADLEALDEAVCEDTAAVIVQYPNFFGRIEPLKDIKPIAHKGKSMFIVS
ANPLALGLLTPPGALGADIVVGDAQPFGIPAAFGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKKGVKEIAWQNLQKAAYAKEAAKRAGLEVAFEGPMFNEFVIRLNEPVEKANER
LLEKNIIGGYDLGASYPDLKRHMLIAVTELRTKEEIDTLMNELGDCHE

Sequences:

>Translated_448_residues
MKHRYLPATDQDKKEMLEAIGVERIDELFSDIPESVRFKGEYQIKKAKSETELTKELTKLAAKNKDTVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDISNSSMYDGGTALAEAAMLASGHTKKKKIVV
SETVHPESREVLKTYAKGQYIDVVEVPSKNGTADLEALDEAVCEDTAAVIVQYPNFFGRIEPLKDIKPIAHKGKSMFIVS
ANPLALGLLTPPGALGADIVVGDAQPFGIPAAFGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKKGVKEIAWQNLQKAAYAKEAAKRAGLEVAFEGPMFNEFVIRLNEPVEKANER
LLEKNIIGGYDLGASYPDLKRHMLIAVTELRTKEEIDTLMNELGDCHE
>Mature_448_residues
MKHRYLPATDQDKKEMLEAIGVERIDELFSDIPESVRFKGEYQIKKAKSETELTKELTKLAAKNKDTVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDISNSSMYDGGTALAEAAMLASGHTKKKKIVV
SETVHPESREVLKTYAKGQYIDVVEVPSKNGTADLEALDEAVCEDTAAVIVQYPNFFGRIEPLKDIKPIAHKGKSMFIVS
ANPLALGLLTPPGALGADIVVGDAQPFGIPAAFGGPHCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKKGVKEIAWQNLQKAAYAKEAAKRAGLEVAFEGPMFNEFVIRLNEPVEKANER
LLEKNIIGGYDLGASYPDLKRHMLIAVTELRTKEEIDTLMNELGDCHE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=405, Percent_Identity=36.7901234567901, Blast_Score=274, Evalue=1e-73,
Organism=Escherichia coli, GI1789269, Length=358, Percent_Identity=36.0335195530726, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=396, Percent_Identity=40.4040404040404, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6323843, Length=363, Percent_Identity=40.495867768595, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24645648, Length=409, Percent_Identity=37.1638141809291, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_BACLD (Q65HG0)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079783.1
- RefSeq:   YP_092197.1
- HSSP:   Q5SKW8
- ProteinModelPortal:   Q65HG0
- SMR:   Q65HG0
- STRING:   Q65HG0
- EnsemblBacteria:   EBBACT00000054947
- EnsemblBacteria:   EBBACT00000059728
- GeneID:   3027813
- GeneID:   3097436
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02630
- KEGG:   bli:BL01561
- NMPDR:   fig|279010.5.peg.475
- eggNOG:   COG0403
- GeneTree:   EBGT00050000001780
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   BLIC279010-1:BLI02630-MONOMER
- BioCyc:   BLIC279010:BL01561-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49307; Mature: 49307

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRYLPATDQDKKEMLEAIGVERIDELFSDIPESVRFKGEYQIKKAKSETELTKELTKL
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHCCCCCEEEHHHHHHHHHHHHHHHH
AAKNKDTVTYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDISNSSMYDGGTALAEAAMLASGHTKKKKIVVSETVHPESREVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCE
IDVVEVPSKNGTADLEALDEAVCEDTAAVIVQYPNFFGRIEPLKDIKPIAHKGKSMFIVS
EEEEECCCCCCCCHHHHHHHHHHCCHHHEEEECCCHHCCCCCHHHCCHHHHCCCEEEEEE
ANPLALGLLTPPGALGADIVVGDAQPFGIPAAFGGPHCGFFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKKGVKEIAWQNLQ
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAAYAKEAAKRAGLEVAFEGPMFNEFVIRLNEPVEKANERLLEKNIIGGYDLGASYPDLK
HHHHHHHHHHHCCCEEEECCCCHHHHHHEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RHMLIAVTELRTKEEIDTLMNELGDCHE
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHRYLPATDQDKKEMLEAIGVERIDELFSDIPESVRFKGEYQIKKAKSETELTKELTKL
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHCCCCCEEEHHHHHHHHHHHHHHHH
AAKNKDTVTYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDISNSSMYDGGTALAEAAMLASGHTKKKKIVVSETVHPESREVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCE
IDVVEVPSKNGTADLEALDEAVCEDTAAVIVQYPNFFGRIEPLKDIKPIAHKGKSMFIVS
EEEEECCCCCCCCHHHHHHHHHHCCHHHEEEECCCHHCCCCCHHHCCHHHHCCCEEEEEE
ANPLALGLLTPPGALGADIVVGDAQPFGIPAAFGGPHCGFFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKKGVKEIAWQNLQ
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAAYAKEAAKRAGLEVAFEGPMFNEFVIRLNEPVEKANERLLEKNIIGGYDLGASYPDLK
HHHHHHHHHHHCCCEEEECCCCHHHHHHEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RHMLIAVTELRTKEEIDTLMNELGDCHE
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA