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The map label for this gene is gcvPB

Identifier: 52786367

GI number: 52786367

Start: 2543152

End: 2544609

Strand: Reverse

Name: gcvPB

Synonym: BLi02629

Alternate gene names: 52786367

Gene position: 2544609-2543152 (Counterclockwise)

Preceding gene: 52786368

Following gene: 52786366

Centisome position: 60.26

GC content: 50.55

Gene sequence:

>1458_bases
ATGAATAATCAGGATCAATCGCTTATTTTTGAAGTATCAAAAGAAGGGCGGGTCGGCTACAGCCTTCCTGAGCTTGACGT
CCCTGAAACAGATGTGACAGACGTCATTGACGAAGCGTATATCAGAGACGAACCGGCAGATCTCCCCGAAGTGTCCGAGC
TTGATATTATGCGCCATTATACGGCTTTATCTAGGCGCAACCACGGAGTGGATTCGGGATTTTATCCGCTCGGTTCGTGC
ACGATGAAGTACAATCCGAAGATTAACGAAAAAATCGCGAGAATCCCTGGATTTTCTGCGATCCATCCGCTCCAGGATGA
AGCGACCGTGCAGGGTGCGCTGGAACTTTTGTACGACTTGAGCGAGCATTTGGAAGAGATCACAGGAATGGATGAGGTCA
CCCTTCAGCCGGCTGCCGGCGCGCACGGCGAGTGGACCGGGCTGATGATGATCCGCGCGTTCCATGAGGCAAACGGCGAT
CATAAAAGGACGAAGGTTATTGTTCCTGATTCGGCCCACGGTACAAATCCGGCGTCTGCGACTGTTGCCGGATTTGAAAC
GGTCACCGTCAAATCGAATGACGACGGCCTTGTTGATCTGGAAGATTTAAAGCGTGTCGTAGACGAAGAAACTGCCGCGT
TAATGCTGACCAATCCAAATACGCTCGGCCTTTTTGAGGAAAATATTTTAGAAATGGCTGAAATCGTCCATAGTGCCGGA
GGAAAGCTGTACTATGACGGAGCGAACCTCAACGCCGTACTCAGCAAAGCAAGGCCGGGTGACATGGGATTCGACGTCGT
CCATTTGAATCTTCACAAAACCTTTACGGGACCGCACGGAGGCGGAGGACCTGGGTCAGGTCCTGTCGGCGTTAAGAAGG
AATTGATACCGTATTTGCCGAAGCCGGTGCTTGTGAAAAAAGACGGACGCTATACTTTTGACCATGACCGTCCGCATTCG
ATCGGCAGGGTGAAACCTTACTACGGAAACTTCGGGATCAATGTGAGGGCATATACGTACATTCGTTCAATGGGGCCGGA
CGGGCTCAAAGAAGTGACGGAAAACGCCGTTTTAAATGCGAATTATATGATGAGAAAGCTTGCTCCTTACTACGATCTGC
CGTTTGACCGACACTCCAAGCACGAATTTGTGCTGTCGGGAAGGCGCCAGAAAAAGCTGGGAGTCAGAACGCTTGACATT
GCAAAGCGCCTTTTGGACTTCGGCTTCCATCCGCCGACCATCTATTTCCCGCTCAATGTCGAGGAATGCATCATGATTGA
ACCGACAGAAACAGAGTCGAAAGAAACGCTCGATGCGTTTATCGATACGATGATCCAGATCGCAAAAGAAGCGGAGGAAA
CGCCTGAAGTCGTTCAGGAAGCACCGCATACAACCGTTGTGAAACGCATGGATGAAACAAAAGCTGCGCGGAAGCCCGTG
CTGCGCTATGAAAAATGA

Upstream 100 bases:

>100_bases
GCTTCATATCCGGATTTAAAACGGCACATGCTGATCGCCGTGACAGAGCTCAGAACAAAAGAGGAAATCGATACACTCAT
GAATGAATTGGGGGATTGCC

Downstream 100 bases:

>100_bases
TAAGAAAGCCGGCGGATCGATTTCGCCGGTTTTTTTTATGTGAAAAATAATATCTTTATGTAAGCGATTTACTGATTGAA
TGAGAAGGATGTCTCCCGTA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MNNQDQSLIFEVSKEGRVGYSLPELDVPETDVTDVIDEAYIRDEPADLPEVSELDIMRHYTALSRRNHGVDSGFYPLGSC
TMKYNPKINEKIARIPGFSAIHPLQDEATVQGALELLYDLSEHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAFHEANGD
HKRTKVIVPDSAHGTNPASATVAGFETVTVKSNDDGLVDLEDLKRVVDEETAALMLTNPNTLGLFEENILEMAEIVHSAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELIPYLPKPVLVKKDGRYTFDHDRPHS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKEVTENAVLNANYMMRKLAPYYDLPFDRHSKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGFHPPTIYFPLNVEECIMIEPTETESKETLDAFIDTMIQIAKEAEETPEVVQEAPHTTVVKRMDETKAARKPV
LRYEK

Sequences:

>Translated_485_residues
MNNQDQSLIFEVSKEGRVGYSLPELDVPETDVTDVIDEAYIRDEPADLPEVSELDIMRHYTALSRRNHGVDSGFYPLGSC
TMKYNPKINEKIARIPGFSAIHPLQDEATVQGALELLYDLSEHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAFHEANGD
HKRTKVIVPDSAHGTNPASATVAGFETVTVKSNDDGLVDLEDLKRVVDEETAALMLTNPNTLGLFEENILEMAEIVHSAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELIPYLPKPVLVKKDGRYTFDHDRPHS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKEVTENAVLNANYMMRKLAPYYDLPFDRHSKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGFHPPTIYFPLNVEECIMIEPTETESKETLDAFIDTMIQIAKEAEETPEVVQEAPHTTVVKRMDETKAARKPV
LRYEK
>Mature_485_residues
MNNQDQSLIFEVSKEGRVGYSLPELDVPETDVTDVIDEAYIRDEPADLPEVSELDIMRHYTALSRRNHGVDSGFYPLGSC
TMKYNPKINEKIARIPGFSAIHPLQDEATVQGALELLYDLSEHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAFHEANGD
HKRTKVIVPDSAHGTNPASATVAGFETVTVKSNDDGLVDLEDLKRVVDEETAALMLTNPNTLGLFEENILEMAEIVHSAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELIPYLPKPVLVKKDGRYTFDHDRPHS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKEVTENAVLNANYMMRKLAPYYDLPFDRHSKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGFHPPTIYFPLNVEECIMIEPTETESKETLDAFIDTMIQIAKEAEETPEVVQEAPHTTVVKRMDETKAARKPV
LRYEK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=414, Percent_Identity=43.4782608695652, Blast_Score=288, Evalue=6e-78,
Organism=Escherichia coli, GI1789269, Length=446, Percent_Identity=39.6860986547085, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17535605, Length=410, Percent_Identity=41.7073170731707, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI32564013, Length=366, Percent_Identity=43.1693989071038, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=43.6781609195402, Blast_Score=321, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=41.9902912621359, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_BACLD (Q65HG1)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079782.1
- RefSeq:   YP_092196.1
- HSSP:   Q5SKW7
- ProteinModelPortal:   Q65HG1
- STRING:   Q65HG1
- EnsemblBacteria:   EBBACT00000055890
- EnsemblBacteria:   EBBACT00000061742
- GeneID:   3029135
- GeneID:   3097435
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02629
- KEGG:   bli:BL01560
- NMPDR:   fig|279010.5.peg.474
- eggNOG:   COG1003
- GeneTree:   EBGT00050000001780
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   BLIC279010-1:BLI02629-MONOMER
- BioCyc:   BLIC279010:BL01560-MONOMER
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 54017; Mature: 54017

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQDQSLIFEVSKEGRVGYSLPELDVPETDVTDVIDEAYIRDEPADLPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TALSRRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFSAIHPLQDEATVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
SEHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAFHEANGDHKRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCE
TVAGFETVTVKSNDDGLVDLEDLKRVVDEETAALMLTNPNTLGLFEENILEMAEIVHSAG
EEECEEEEEEECCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCC
KPVLVKKDGRYTFDHDRPHSIGRVKPYYGNFGINVRAYTYIRSMGPDGLKEVTENAVLNA
CCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHEECH
NYMMRKLAPYYDLPFDRHSKHEFVLSGRRQKKLGVRTLDIAKRLLDFGFHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDAFIDTMIQIAKEAEETPEVVQEAPHTTVVKRMDETKAARKPV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCC
LRYEK
CCCCC
>Mature Secondary Structure
MNNQDQSLIFEVSKEGRVGYSLPELDVPETDVTDVIDEAYIRDEPADLPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TALSRRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFSAIHPLQDEATVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
SEHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAFHEANGDHKRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCE
TVAGFETVTVKSNDDGLVDLEDLKRVVDEETAALMLTNPNTLGLFEENILEMAEIVHSAG
EEECEEEEEEECCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKELIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCC
KPVLVKKDGRYTFDHDRPHSIGRVKPYYGNFGINVRAYTYIRSMGPDGLKEVTENAVLNA
CCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHEECH
NYMMRKLAPYYDLPFDRHSKHEFVLSGRRQKKLGVRTLDIAKRLLDFGFHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDAFIDTMIQIAKEAEETPEVVQEAPHTTVVKRMDETKAARKPV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCC
LRYEK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA