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The map label for this gene is trpC

Identifier: 52786145

GI number: 52786145

Start: 2344831

End: 2345589

Strand: Reverse

Name: trpC

Synonym: BLi02401

Alternate gene names: 52786145

Gene position: 2345589-2344831 (Counterclockwise)

Preceding gene: 52786146

Following gene: 52786144

Centisome position: 55.55

GC content: 47.17

Gene sequence:

>759_bases
ATGCTTAATCAAATTATTGATAGAAAACGAGAAGACATCCTAAAGATCAAGCTGTCGGAAGATTTAAAACTGCCAAAGCG
GTCATTTAAAAAAGCGCTCCTTTCTCCGAACCGGTTTGTCGCTTTAATTGCGGAGGTGAAAAAAGCTTCTCCGTCAAAAG
GCGTGATTCAGGAGGGTTTTGAGCCCGTCAAGATCGCAAAACAATACGAACAGGCTAAAGCCGATTGTTTGTCTGTTCTG
ACAGATACACCTTTTTTTCAAGGGAAGAACAGTTATTTGTCAGATGTGAAACGCTCGGTTTCCCTGCCTGTGCTGCGCAA
GGATTTTATCATTGATTCCATTCAGGTTGAAGAAGCGGACCGCATCGGAGCGGATGCGATCCTGCTGATCGGTGAAGCGC
TTGAACCGCAAAAGCTGTTTGAACTCTATCAGCAAGCCGTTGAAAAAGGCATGGATGTGCTCGTCGAAGTACATGGCGAA
GAGACGCTTGAGGGCATTTTAAATGTCTTTACACCCGAAATCATCGGCGTAAACAATCGAAATCTAAAAAACTTTGAAAC
GACCGTCGGACAAACGGAGCGAATGGCGAAACTCGTTCCGCCGGGGACCGTTCTCATCAGCGAAAGCGGCATCGGAAAAT
CGGAAGACCTGACTTTTGTAAAAACGTGCGGAGCCCAAGCCGTGCTTGTCGGCGAATCGCTGATGAGAGAGACGTCACAG
CTGAAGGCTGTCTATGCGTTATTCGGAGAGGACGGCTGA

Upstream 100 bases:

>100_bases
GCGGATTTAAAAGAGGGCGTTGCGCTCGCTTTAGAAGCTGTTGCTGGCGGTGAAGCGCTCAATCAGCTGGAGCGATTAAA
ACAGAAAGAGGAAGAGTTGT

Downstream 100 bases:

>100_bases
TGAAGAAACCGAGTCTAAAATATTGCGGGATTCATTCATTGGAAGATTTAAAGGTGACAGCCCGCTCGAAAGCCGATTAT
CTCGGATTTATTTTCGCCGA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MLNQIIDRKREDILKIKLSEDLKLPKRSFKKALLSPNRFVALIAEVKKASPSKGVIQEGFEPVKIAKQYEQAKADCLSVL
TDTPFFQGKNSYLSDVKRSVSLPVLRKDFIIDSIQVEEADRIGADAILLIGEALEPQKLFELYQQAVEKGMDVLVEVHGE
ETLEGILNVFTPEIIGVNNRNLKNFETTVGQTERMAKLVPPGTVLISESGIGKSEDLTFVKTCGAQAVLVGESLMRETSQ
LKAVYALFGEDG

Sequences:

>Translated_252_residues
MLNQIIDRKREDILKIKLSEDLKLPKRSFKKALLSPNRFVALIAEVKKASPSKGVIQEGFEPVKIAKQYEQAKADCLSVL
TDTPFFQGKNSYLSDVKRSVSLPVLRKDFIIDSIQVEEADRIGADAILLIGEALEPQKLFELYQQAVEKGMDVLVEVHGE
ETLEGILNVFTPEIIGVNNRNLKNFETTVGQTERMAKLVPPGTVLISESGIGKSEDLTFVKTCGAQAVLVGESLMRETSQ
LKAVYALFGEDG
>Mature_252_residues
MLNQIIDRKREDILKIKLSEDLKLPKRSFKKALLSPNRFVALIAEVKKASPSKGVIQEGFEPVKIAKQYEQAKADCLSVL
TDTPFFQGKNSYLSDVKRSVSLPVLRKDFIIDSIQVEEADRIGADAILLIGEALEPQKLFELYQQAVEKGMDVLVEVHGE
ETLEGILNVFTPEIIGVNNRNLKNFETTVGQTERMAKLVPPGTVLISESGIGKSEDLTFVKTCGAQAVLVGESLMRETSQ
LKAVYALFGEDG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=226, Percent_Identity=36.283185840708, Blast_Score=114, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=35.4700854700855, Blast_Score=122, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACLD (Q65I33)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079565.1
- RefSeq:   YP_091974.1
- HSSP:   Q56319
- ProteinModelPortal:   Q65I33
- SMR:   Q65I33
- STRING:   Q65I33
- EnsemblBacteria:   EBBACT00000054941
- EnsemblBacteria:   EBBACT00000059914
- GeneID:   3028345
- GeneID:   3100736
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02401
- KEGG:   bli:BL02773
- NMPDR:   fig|279010.5.peg.251
- eggNOG:   COG0134
- GeneTree:   EBGT00050000001798
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   BLIC279010-1:BLI02401-MONOMER
- BioCyc:   BLIC279010:BL02773-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27868; Mature: 27868

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQIIDRKREDILKIKLSEDLKLPKRSFKKALLSPNRFVALIAEVKKASPSKGVIQEGF
CCHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHCCC
EPVKIAKQYEQAKADCLSVLTDTPFFQGKNSYLSDVKRSVSLPVLRKDFIIDSIQVEEAD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
RIGADAILLIGEALEPQKLFELYQQAVEKGMDVLVEVHGEETLEGILNVFTPEIIGVNNR
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHCCCEECCCCC
NLKNFETTVGQTERMAKLVPPGTVLISESGIGKSEDLTFVKTCGAQAVLVGESLMRETSQ
CCCHHHHHHCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHH
LKAVYALFGEDG
HHHHHHHHCCCC
>Mature Secondary Structure
MLNQIIDRKREDILKIKLSEDLKLPKRSFKKALLSPNRFVALIAEVKKASPSKGVIQEGF
CCHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHCCC
EPVKIAKQYEQAKADCLSVLTDTPFFQGKNSYLSDVKRSVSLPVLRKDFIIDSIQVEEAD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
RIGADAILLIGEALEPQKLFELYQQAVEKGMDVLVEVHGEETLEGILNVFTPEIIGVNNR
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHCCCEECCCCC
NLKNFETTVGQTERMAKLVPPGTVLISESGIGKSEDLTFVKTCGAQAVLVGESLMRETSQ
CCCHHHHHHCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHH
LKAVYALFGEDG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA