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The map label for this gene is yacK

Identifier: 52783944

GI number: 52783944

Start: 106242

End: 107318

Strand: Direct

Name: yacK

Synonym: BLi00106

Alternate gene names: 52783944

Gene position: 106242-107318 (Clockwise)

Preceding gene: 52783943

Following gene: 52783945

Centisome position: 2.52

GC content: 44.85

Gene sequence:

>1077_bases
ATGGACAAAGACAAAAAAGGAGCGAAACAGGATCTTTCAGAAATATTGCAGTTTGTCGCCCCCGGCACGCCTCTTCGCGA
AGGAATCGAAAACGTCCTTCGGGCCAAAACAGGCGGATTAATCGTGGTCGGCTTCAACGATAAAGTGAAAGAAGTGGTTG
ACGGAGGGTTCCACATAAATTCTTCTTTCTCTCCGGCTCATCTGTACGAGCTGGCTAAAATGGACGGGGCGATCATTCTC
AGCGATTCAGGGCAAAAAATTCTATATGCCAATACACAGCTCATGCCTGAGGCGACGATTCCCTCCTCTGAGACGGGCAT
GAGACACAGAACAGCCGAGCGTGTGGCCAAGCAGACCGGCTGTCTGATCATCGCGATTTCTGAAAGACGGAATGTGATTA
CGCTCTATCAGGAAAATATGAAATATATACTCAAAGATATCGGCTTTATCTTAACAAAAGCCAATCAGGCGATTCAGACG
CTCGAAAAATACAAACTCATTTTGGACCATGCGATTTCCAATTTGAACGCGCTGGAATTTGAAGAGCTTGTTACATTTGG
GGATGTCATCTCCGTTCTGCATCGATATGAAATGGTGCTCAGAATCAAAAACGAAATTAATATGTATATTAAAGAGCTTG
GAACAGAAGGCCATCTCATCAGACTCCAGGTTAGCGAACTGATCACCGATATGGAGCAGGAAGCGGCGCTGTTCGTCAAA
GATTATGTGAAAGAAAAAATCAAAGACCCGTTTGTTCTGCTGAAACAGCTTCAGGATATGTCGAGTTTCGAATTGCTGGA
TGATGCGATTCTCCTTAAGCTTTTAGGCTATTCAGCAACTACGAACATGGAAGAATACGTTTTTCCGAGAGGCTACAGGC
TTCTCCACAAAATTCCCCGCCTCCCGATGCCGATCGTCGAAAATGTTGTCGAAGCATTCGGCCATTTAAAGCTCATTATC
GAAGCGGATGTAAAAGATTTGGATGAAGTGGAAGGAATTGGGGCTGTTCGTGCCCAAAAGATAAAGAAAGGGTTAAAGAG
ACTTCAGGAGAAACATTATACTGACAGGCAGCTGTGA

Upstream 100 bases:

>100_bases
TGCAAATGTAGAAGGATGGACAAAGCCGAAAGGAATCGAAGTCGTCGGCGTTGAAAATGTAGCTGAGGCCCTTCGAGCTT
CATTAGGAGGATCATAATAT

Downstream 100 bases:

>100_bases
GAAAATTTTCTAGAAGTGATTAAAATTTGCAATTTATGGGTATATTATTCTTACTTTTTGTTTTCCCTTTTTCACGTGGA
AACAGCTGCATTTATAAAAA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHINSSFSPAHLYELAKMDGAIIL
SDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTGCLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQT
LEKYKLILDHAISNLNALEFEELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVK
DYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPRLPMPIVENVVEAFGHLKLII
EADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL

Sequences:

>Translated_358_residues
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHINSSFSPAHLYELAKMDGAIIL
SDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTGCLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQT
LEKYKLILDHAISNLNALEFEELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVK
DYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPRLPMPIVENVVEAFGHLKLII
EADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL
>Mature_358_residues
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHINSSFSPAHLYELAKMDGAIIL
SDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTGCLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQT
LEKYKLILDHAISNLNALEFEELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVK
DYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPRLPMPIVENVVEAFGHLKLII
EADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_BACLD (Q65PD4)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_077374.1
- RefSeq:   YP_089773.1
- HSSP:   P24480
- ProteinModelPortal:   Q65PD4
- SMR:   Q65PD4
- STRING:   Q65PD4
- EnsemblBacteria:   EBBACT00000054713
- EnsemblBacteria:   EBBACT00000059194
- GeneID:   3028784
- GeneID:   3100457
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00106
- KEGG:   bli:BL03263
- NMPDR:   fig|279010.5.peg.1483
- eggNOG:   COG1623
- GeneTree:   EBGT00050000001567
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- BioCyc:   BLIC279010-1:BLI00106-MONOMER
- BioCyc:   BLIC279010:BL03263-MONOMER
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00278

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 40583; Mature: 40583

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00389 ATPASE_DELTA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHIN
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEC
SSFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTG
CCCCHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHCC
CLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQTLEKYKLILDHAISNLNALEF
EEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
DYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPR
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCC
LPMPIVENVVEAFGHLKLIIEADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL
CCHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHIN
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEC
SSFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTG
CCCCHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHCC
CLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQTLEKYKLILDHAISNLNALEF
EEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
DYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPR
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCC
LPMPIVENVVEAFGHLKLIIEADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL
CCHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA