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The map label for this gene is nuoH2

Identifier: 51893911

GI number: 51893911

Start: 2992795

End: 2993979

Strand: Reverse

Name: nuoH2

Synonym: STH2773

Alternate gene names: 51893911

Gene position: 2993979-2992795 (Counterclockwise)

Preceding gene: 51893912

Following gene: 51893910

Centisome position: 83.96

GC content: 64.81

Gene sequence:

>1185_bases
GTGATGGAGTGGTGGAACAGCCTCTCGCCCACCGTGCAGGTCTGGCTCGGCGGGGTCCTGAAGGCGAGCCTGATCCTGGT
CTGGGGGCTGATCAACTTCTACCTCTGCCTCATGCTGGAGCGGAAGCTGTCGGCGTGGATGCAGAACCGAGTCGGCCCCT
GGCGGGTCGGCCTGTGGGGCTGGATTCAGCCCGTCGCCGACCTGATCAAGCTGTGGGTGAAGGAGTACATCCGGCCGAAC
AACGTCGACAAGTGGCTGTACCTCATCGCCCCCTTCATCGGCTTCGTCTCGGCTAACCTCGTCTGGCTCATTGTTCCCTT
TGGCGACAAGTTGATCGCCACCGACTTCGAAATCGGCATCATCTTCATCGCCGCGGTCATGGGATACGACGTGATCGCCA
CGTTCATGGCCGGTTGGGGCTCCAACAACAAGTACTCCATGCTGGGCGCGATGCGCGGTGCGGCGCAGCTGATCTCCTAC
GAGGTCACCATGGTGATGGCGGTCATCGGCGTGGTGATGATGGCCGGGTCGCTCAGGCTGTCGGACATCGTGCTGGCGCA
GCAGCAGCGGGGCTTCCTCGGCTGGTTCCTGTTCCCGCAGATCATCGGGTTCATCGTCTACCTGATCGCCTCGCTGGCGG
AGCTGAACCGCGCCCCCTTCGACCTCGCGGAGGCCGAGCAGGAGCTGGTGGCAGGCCACCACACCGAGTACTCGGGCTTC
CGCTGGGCGATGTTCATGCTGGCGGAGTACATCCACCTGGCGGCCTGGTCCGCCATCGCCGCCACCCTCTTCCTGGGCGG
GTGGAGCGGCCCGACCCTGGGCCAGGTGGCGGCAGGGCTCGGCAACGTGCTCAACGGCTTCGGCGCGTTCACGAACCCCG
TGGGCACGGCCGTGCTCAACTGGGGCCTGGCGATCTCGGGCTCCACGATCCTGAACTGGGTCGCCGGCGTGTTCTGGCTG
GTCCTGAAGACGTACTTCTTCGTCTTCCTGGCGATGTGGATCCGCTGGACCCTGCCGCGGGTGCGCATCGACCAGCTGAT
GGACCTGGGCTGGAAGTTCCTCCTGCCGGTCTCCATGTTCAACATCTTCCTGACGGGAACCCTCCGGTACCTCGCCGTCG
CGTTCGACGGGGTGCCGATCTCCATCGGATCCTTCACGCTGCGGCTCCTGGGCTGGTGGCTCTAA

Upstream 100 bases:

>100_bases
ACCTGCAGCTGATGCCGCTCCTGTGCCCGGGCCATAAGATCGCCGACATCATCGCAATCCTGGGCTCCATCGACGTCGTG
CTCGGGGAGGTGGACCGGTA

Downstream 100 bases:

>100_bases
GGGAGGTGTGAACCTGCATGGGCGTTACCAACTTCTTCGGGGAGGCATGGCGCACCGGGAAGTCCATCGTCACCGGACTC
GGCATCACGTTCCGGGAGAT

Product: NADH dehydrogenase I subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 2; NDH-1 subunit H 2

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MMEWWNSLSPTVQVWLGGVLKASLILVWGLINFYLCLMLERKLSAWMQNRVGPWRVGLWGWIQPVADLIKLWVKEYIRPN
NVDKWLYLIAPFIGFVSANLVWLIVPFGDKLIATDFEIGIIFIAAVMGYDVIATFMAGWGSNNKYSMLGAMRGAAQLISY
EVTMVMAVIGVVMMAGSLRLSDIVLAQQQRGFLGWFLFPQIIGFIVYLIASLAELNRAPFDLAEAEQELVAGHHTEYSGF
RWAMFMLAEYIHLAAWSAIAATLFLGGWSGPTLGQVAAGLGNVLNGFGAFTNPVGTAVLNWGLAISGSTILNWVAGVFWL
VLKTYFFVFLAMWIRWTLPRVRIDQLMDLGWKFLLPVSMFNIFLTGTLRYLAVAFDGVPISIGSFTLRLLGWWL

Sequences:

>Translated_394_residues
MMEWWNSLSPTVQVWLGGVLKASLILVWGLINFYLCLMLERKLSAWMQNRVGPWRVGLWGWIQPVADLIKLWVKEYIRPN
NVDKWLYLIAPFIGFVSANLVWLIVPFGDKLIATDFEIGIIFIAAVMGYDVIATFMAGWGSNNKYSMLGAMRGAAQLISY
EVTMVMAVIGVVMMAGSLRLSDIVLAQQQRGFLGWFLFPQIIGFIVYLIASLAELNRAPFDLAEAEQELVAGHHTEYSGF
RWAMFMLAEYIHLAAWSAIAATLFLGGWSGPTLGQVAAGLGNVLNGFGAFTNPVGTAVLNWGLAISGSTILNWVAGVFWL
VLKTYFFVFLAMWIRWTLPRVRIDQLMDLGWKFLLPVSMFNIFLTGTLRYLAVAFDGVPISIGSFTLRLLGWWL
>Mature_394_residues
MMEWWNSLSPTVQVWLGGVLKASLILVWGLINFYLCLMLERKLSAWMQNRVGPWRVGLWGWIQPVADLIKLWVKEYIRPN
NVDKWLYLIAPFIGFVSANLVWLIVPFGDKLIATDFEIGIIFIAAVMGYDVIATFMAGWGSNNKYSMLGAMRGAAQLISY
EVTMVMAVIGVVMMAGSLRLSDIVLAQQQRGFLGWFLFPQIIGFIVYLIASLAELNRAPFDLAEAEQELVAGHHTEYSGF
RWAMFMLAEYIHLAAWSAIAATLFLGGWSGPTLGQVAAGLGNVLNGFGAFTNPVGTAVLNWGLAISGSTILNWVAGVFWL
VLKTYFFVFLAMWIRWTLPRVRIDQLMDLGWKFLLPVSMFNIFLTGTLRYLAVAFDGVPISIGSFTLRLLGWWL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=323, Percent_Identity=33.1269349845201, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1788618, Length=361, Percent_Identity=38.5041551246537, Blast_Score=232, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH2_SYMTH (Q67KP0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076602.1
- GeneID:   2979667
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2773
- HOGENOM:   HBG727670
- OMA:   NSFWIIP
- BioCyc:   STHE292459:STH2773-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 44178; Mature: 44178

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x152e4b58)-; HASH(0x1567b2e4)-; HASH(0x15300ed8)-; HASH(0x1528c0bc)-; HASH(0x152b4dbc)-; HASH(0x14debe00)-; HASH(0x14eb9ee0)-; HASH(0x153d58b8)-; HASH(0x1498033c)-; HASH(0x120f4e20)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA