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The map label for this gene is nuoD2

Identifier: 51893912

GI number: 51893912

Start: 2993979

End: 2995133

Strand: Reverse

Name: nuoD2

Synonym: STH2774

Alternate gene names: 51893912

Gene position: 2995133-2993979 (Counterclockwise)

Preceding gene: 51893913

Following gene: 51893911

Centisome position: 83.99

GC content: 65.37

Gene sequence:

>1155_bases
GTGAACGTGGAACGGACGCAAGAGCTACTGGTCAACATGGGCCCGCAGCACCCCTCCACCCACGGCGTGCTCCGCCTGAT
GATCAAACTGGACGGGGAACAGGTGACCTGGTGCGAGCCCGACATCGGCTACCTGCACCGCTGCTTCGAGAAGCTGGCGG
AGCAGAAGACCTATCCTCAGGTGATTCCGTTCACCGACCGGACGGACTACCTGGCCGCCATGCTCAACGAGCTCTGCTAC
GTGGAGGCCGTGGAAAAGTTGTTCGGCGACGCCATCCAGGTGCCGGAGCGGGCGCAGTACATCCGGGTGATGCTGGCGGA
GCTGCAGCGGATCACCTCGCACCTGCTCGCCCTGGGCTCGATGGCGATGGACCTGGGGGCGACGACGCCGTTCCTGTACT
GCTGGCGTGACCGCGAGAAGCTGTACTCCCTCTTCGAGCGCATCACCGGCGGGCGCATGCTCTACAACTACCTGCGCATC
GGCGGCGTGCGCAACGACCTGCCCGAGGGCATCCTCGGCACCCCGCAGGATGGCGAGGACAAGGCCGACAAGACCATCTG
GGGCTTCATCAACTACTTTGACTCGTACGTCTACCCGGAGTGGAAGGCCCTGGTGACGGGCAACCGCATCTTCCAGTACC
GCACGAAGAACATCGGCGTGCTCACGGCCGAGCAGGCCATTGCCTACTCGTGCTCGGGCGCGGTGCTGCGCGGCTCGGGT
GTGAAGTGGGACCTGCGCAAGAACCTGCCCTACGCCATCTACGACCGGTTCGAGTTCGACATCCCCGTGGGCCAGAACGG
CGACAGTTTTGACCGGTGGTGGGTCCGGCAGGAGGAGATGTACCAGTCCTCCCGCATCGTCAAGCAGTGCCTGGAGTGGC
TGGCCGAGAACCCGGGCCCGGTCATGGCGCCGAAGATGCCGCGCGTCCTGAAGCCCCCGAAGGGCGAGGTCTACCACCGC
ATCGAGGGCGCCCGGGGCGAGGTCGCCTGCTACGTGGTCTCCGACGGTTCCACCAACCCGTACAAGGTCAAGTGGCGCTC
GCCGGCGTTCACCCACCTGCAGCTGATGCCGCTCCTGTGCCCGGGCCATAAGATCGCCGACATCATCGCAATCCTGGGCT
CCATCGACGTCGTGCTCGGGGAGGTGGACCGGTAG

Upstream 100 bases:

>100_bases
TGGCAGGGTGGCCACCCGCTGCTGAAGGACTTCGCCGATCGGCGGCCCAAGCGCCCGCGGCTGGTGCGGCATCGCTTCGC
CGAATAGCCGGTGCGGAGGT

Downstream 100 bases:

>100_bases
TGATGGAGTGGTGGAACAGCCTCTCGCCCACCGTGCAGGTCTGGCTCGGCGGGGTCCTGAAGGCGAGCCTGATCCTGGTC
TGGGGGCTGATCAACTTCTA

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNVERTQELLVNMGPQHPSTHGVLRLMIKLDGEQVTWCEPDIGYLHRCFEKLAEQKTYPQVIPFTDRTDYLAAMLNELCY
VEAVEKLFGDAIQVPERAQYIRVMLAELQRITSHLLALGSMAMDLGATTPFLYCWRDREKLYSLFERITGGRMLYNYLRI
GGVRNDLPEGILGTPQDGEDKADKTIWGFINYFDSYVYPEWKALVTGNRIFQYRTKNIGVLTAEQAIAYSCSGAVLRGSG
VKWDLRKNLPYAIYDRFEFDIPVGQNGDSFDRWWVRQEEMYQSSRIVKQCLEWLAENPGPVMAPKMPRVLKPPKGEVYHR
IEGARGEVACYVVSDGSTNPYKVKWRSPAFTHLQLMPLLCPGHKIADIIAILGSIDVVLGEVDR

Sequences:

>Translated_384_residues
MNVERTQELLVNMGPQHPSTHGVLRLMIKLDGEQVTWCEPDIGYLHRCFEKLAEQKTYPQVIPFTDRTDYLAAMLNELCY
VEAVEKLFGDAIQVPERAQYIRVMLAELQRITSHLLALGSMAMDLGATTPFLYCWRDREKLYSLFERITGGRMLYNYLRI
GGVRNDLPEGILGTPQDGEDKADKTIWGFINYFDSYVYPEWKALVTGNRIFQYRTKNIGVLTAEQAIAYSCSGAVLRGSG
VKWDLRKNLPYAIYDRFEFDIPVGQNGDSFDRWWVRQEEMYQSSRIVKQCLEWLAENPGPVMAPKMPRVLKPPKGEVYHR
IEGARGEVACYVVSDGSTNPYKVKWRSPAFTHLQLMPLLCPGHKIADIIAILGSIDVVLGEVDR
>Mature_384_residues
MNVERTQELLVNMGPQHPSTHGVLRLMIKLDGEQVTWCEPDIGYLHRCFEKLAEQKTYPQVIPFTDRTDYLAAMLNELCY
VEAVEKLFGDAIQVPERAQYIRVMLAELQRITSHLLALGSMAMDLGATTPFLYCWRDREKLYSLFERITGGRMLYNYLRI
GGVRNDLPEGILGTPQDGEDKADKTIWGFINYFDSYVYPEWKALVTGNRIFQYRTKNIGVLTAEQAIAYSCSGAVLRGSG
VKWDLRKNLPYAIYDRFEFDIPVGQNGDSFDRWWVRQEEMYQSSRIVKQCLEWLAENPGPVMAPKMPRVLKPPKGEVYHR
IEGARGEVACYVVSDGSTNPYKVKWRSPAFTHLQLMPLLCPGHKIADIIAILGSIDVVLGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=403, Percent_Identity=43.9205955334988, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI260898743, Length=397, Percent_Identity=43.0730478589421, Blast_Score=319, Evalue=3e-87,
Organism=Escherichia coli, GI145693162, Length=405, Percent_Identity=39.0123456790123, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI1789076, Length=376, Percent_Identity=27.3936170212766, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788832, Length=387, Percent_Identity=26.0981912144703, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=400, Percent_Identity=41, Blast_Score=310, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17568379, Length=400, Percent_Identity=41, Blast_Score=309, Evalue=1e-84,
Organism=Drosophila melanogaster, GI221459469, Length=407, Percent_Identity=42.997542997543, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24638644, Length=405, Percent_Identity=42.962962962963, Blast_Score=335, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD2_SYMTH (Q67KN9)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076603.1
- HSSP:   Q56220
- ProteinModelPortal:   Q67KN9
- SMR:   Q67KN9
- GeneID:   2979680
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2774
- NMPDR:   fig|292459.1.peg.2651
- HOGENOM:   HBG459705
- OMA:   GDCLSRH
- BioCyc:   STHE292459:STH2774-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 43902; Mature: 43902

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVERTQELLVNMGPQHPSTHGVLRLMIKLDGEQVTWCEPDIGYLHRCFEKLAEQKTYPQ
CCHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCC
VIPFTDRTDYLAAMLNELCYVEAVEKLFGDAIQVPERAQYIRVMLAELQRITSHLLALGS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MAMDLGATTPFLYCWRDREKLYSLFERITGGRMLYNYLRIGGVRNDLPEGILGTPQDGED
HHHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KADKTIWGFINYFDSYVYPEWKALVTGNRIFQYRTKNIGVLTAEQAIAYSCSGAVLRGSG
HHHHHHHHHHHHHHHHCCCCHHEEEECCEEEEEECCCCEEEEHHHHHHEECCCCEEECCC
VKWDLRKNLPYAIYDRFEFDIPVGQNGDSFDRWWVRQEEMYQSSRIVKQCLEWLAENPGP
CEEEHHCCCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VMAPKMPRVLKPPKGEVYHRIEGARGEVACYVVSDGSTNPYKVKWRSPAFTHLQLMPLLC
CCCCCCCHHCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHEEEHHCC
PGHKIADIIAILGSIDVVLGEVDR
CCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVERTQELLVNMGPQHPSTHGVLRLMIKLDGEQVTWCEPDIGYLHRCFEKLAEQKTYPQ
CCHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCC
VIPFTDRTDYLAAMLNELCYVEAVEKLFGDAIQVPERAQYIRVMLAELQRITSHLLALGS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MAMDLGATTPFLYCWRDREKLYSLFERITGGRMLYNYLRIGGVRNDLPEGILGTPQDGED
HHHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KADKTIWGFINYFDSYVYPEWKALVTGNRIFQYRTKNIGVLTAEQAIAYSCSGAVLRGSG
HHHHHHHHHHHHHHHHCCCCHHEEEECCEEEEEECCCCEEEEHHHHHHEECCCCEEECCC
VKWDLRKNLPYAIYDRFEFDIPVGQNGDSFDRWWVRQEEMYQSSRIVKQCLEWLAENPGP
CEEEHHCCCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VMAPKMPRVLKPPKGEVYHRIEGARGEVACYVVSDGSTNPYKVKWRSPAFTHLQLMPLLC
CCCCCCCHHCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHEEEHHCC
PGHKIADIIAILGSIDVVLGEVDR
CCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA