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The map label for this gene is nuoI2

Identifier: 51893910

GI number: 51893910

Start: 2992055

End: 2992777

Strand: Reverse

Name: nuoI2

Synonym: STH2772

Alternate gene names: 51893910

Gene position: 2992777-2992055 (Counterclockwise)

Preceding gene: 51893911

Following gene: 51893909

Centisome position: 83.92

GC content: 66.67

Gene sequence:

>723_bases
ATGGGCGTTACCAACTTCTTCGGGGAGGCATGGCGCACCGGGAAGTCCATCGTCACCGGACTCGGCATCACGTTCCGGGA
GATGATGTTCCGGCCGGCCATCACCGTGTTCTACCCCGAGCAGCGTGACGACGTGCCCCCCTGGTTCCGGGGCATCCCGG
TCCTGAAGACCGACCTGCGCACCGGCGAGTACAAGTGCACGTCCTGCATGCAGTGCGCGCAGGCCTGTCCGGTGAACGTC
ATCACGATCGAGTGGCACCAGGACCCGGAGACCAAGAAGAAGGTCTGTGACCGGTTCGCCATCGACATGTCCCGGTGCAT
GCTCTGCAACTTCTGCGTCGAGGCGTGCCCCTTCGACTCCCTGGTCATGGGTTACGACTACGAGCTCTGCAAGGTGAACC
CGGAGAACCTGGTCTTCGAGTTCGAGGACCTGCTCAGGCTCGGGCTGAAGTACTCGAAGGCCGAGGAGCCCGGCCCCAAG
GCCACCCGCTCGTCCACGCCGCCCTGGGTCTTCCACGGGCTGACCAACGCCACGGAGGACGACATTCAGGACATCCACGG
GTACCTGGGGCGTCCGCCCCTGCCCAAGGGATACGAGCCTGAGCTGAAGCCGCAGTTCCGGAAGCCGGCCGAGGAGGCCG
CGGAGGCGCAGCAGGCGGAGGCCGCGGGCCAGCCGGCAGCGGAGCCGGGCAAGACCAACGGGGAGGAGGCCGGGCAGCCG
TGA

Upstream 100 bases:

>100_bases
TCCGGTACCTCGCCGTCGCGTTCGACGGGGTGCCGATCTCCATCGGATCCTTCACGCTGCGGCTCCTGGGCTGGTGGCTC
TAAGGGAGGTGTGAACCTGC

Downstream 100 bases:

>100_bases
CAACAGACCTGCTCATGAGCGGCCAGTTCTGGACCTTCATCATCCTCGCGGTGGTCACCCTGGTGTCGACCTACCGCATG
GTCACCACGCCGCTCATCAC

Product: NADH dehydrogenase I subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 2; NDH-1 subunit I 2

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLRTGEYKCTSCMQCAQACPVNV
ITIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDSLVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPK
ATRSSTPPWVFHGLTNATEDDIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP

Sequences:

>Translated_240_residues
MGVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLRTGEYKCTSCMQCAQACPVNV
ITIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDSLVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPK
ATRSSTPPWVFHGLTNATEDDIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP
>Mature_239_residues
GVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLRTGEYKCTSCMQCAQACPVNVI
TIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDSLVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPKA
TRSSTPPWVFHGLTNATEDDIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=135, Percent_Identity=35.5555555555556, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1788617, Length=144, Percent_Identity=36.8055555555556, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555194, Length=148, Percent_Identity=33.7837837837838, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864306, Length=148, Percent_Identity=35.1351351351351, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI2_SYMTH (Q67KP1)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076601.1
- ProteinModelPortal:   Q67KP1
- SMR:   Q67KP1
- GeneID:   2979666
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2772
- NMPDR:   fig|292459.1.peg.2649
- OMA:   VITIEWH
- BioCyc:   STHE292459:STH2772-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR010226

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 26924; Mature: 26793

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLR
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCCCCCCCCHHHHCCCHHHHCCC
TGEYKCTSCMQCAQACPVNVITIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDS
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPKATRSSTPPWVFHGLTNATED
HHHCCCCEEEEECHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCHH
DIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP
HHHHHHHHHCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCCCCCCCCHHHHCCCHHHHCCC
TGEYKCTSCMQCAQACPVNVITIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDS
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPKATRSSTPPWVFHGLTNATED
HHHCCCCEEEEECHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCHH
DIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP
HHHHHHHHHCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA