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The map label for this gene is nuoM2 [H]

Identifier: 51893906

GI number: 51893906

Start: 2987594

End: 2989120

Strand: Reverse

Name: nuoM2 [H]

Synonym: STH2768

Alternate gene names: 51893906

Gene position: 2989120-2987594 (Counterclockwise)

Preceding gene: 51893907

Following gene: 51893905

Centisome position: 83.82

GC content: 64.77

Gene sequence:

>1527_bases
ATGCTGTCGCTAATCATCTTTGTACCCCTGGTCTTCGCCCTCGTGATGCTGTTCTTTGTGCCGAAGACCCAGGAGCGGCT
CCTGTACTGGCTCGCGGGGATCGGTACCCTCATCCCGTTCGCGCTGGCCCTGGTGCTGGCCGCTCAGTGGCCGACCGCAG
AGGTCTCCACGGCCCCCTACGCCCAGGGCATGCGGTTCGTGACCCACGTCCCGTGGATCCAGGCCATCGGCGTGCACTAC
ACGCTGGGCGTGGACGGCTTCGCCTTCACGATGCTGCTGCTCTCGACGCTGCTGTTCCCTCTCGCCGTGCTGGCCTCCTA
CGGGTACATCAAGGACCGGGTGAAGGACTACCTCGTCCTGCTGCTCATCCTGGCCACCGGCACCAACGGCGTGTTCGCCA
CCCTGGACTTCATGCTCTTCTACGTGTTCTGGGAGATCGTGCTGCTGCCGATGTACTTCCTGATCGGCATCTGGGGCGGC
GAGCGGCGCGAGTACGCGGCCATCAAGTTCTTCCTCTACACCCTGATCGGTTCGACCGTCATGCTGGTCGGCGCCATCTA
CCTCTACGTCGCCACCGGCGTCGGCACGTTCAACCTGCTGCAGATGGCGGCGGCCTCTTCCAAGCTGCCCATCACCGGCC
TCACCACCTTCGCCTTCTTCGCCCTGCTGGTGGGCTTCGCGGTGAAGGTGCCCATGTTCCCGTTCCACACCTGGTTGCCT
GACGCCCACGTCGAAGCGCCCACGCCCATCTCGATGCTGCTGGCCGGCATCCTGCTGAAGCTGGGCTCCTACGCCATGGT
GCGCATCAGCCATCCGATGCTGCCGCAGCTGGCGACCAAGTACGCGGACCTGCTGTTCGTCTTCGGCGTGGTCGGCATCC
TCTACGCAGCCCTGGCGGCGATGGCGCAGAAGGATTTCAAGAAGCAGGTCGCCTACTCGTCGGTCAACCACATGGGCTTC
TTCATCATGGCCCTGGCGGCCGCGAGCAAGCTGGCGCCCACCAGCCCTGAGCTGGCGCAGGTGGCGCTGCAGGGCGGCTA
CTTCGTGACCATCGCCCACGGACTGATCTCGCCCCTGTTCTTCTTCGCCGTCGGCATGTTCTACGAGCGCACGCACACCC
GTGACCTGCGGAAGCTGGGCGGCATGTTCCTGACGATCCCGGTCGTCTCCTTCGCCACGGCCTTTGTCGCCTTCGCCAAC
CTGGGCCTGCCCGGCCTGGCCGGTTTCATCGGCGAGTTCATCTCGCTCACCGGCTCCTACCCGGCGTTCGGGCTCTGGGT
GCTGGTGGCCGGTCTCGGCATGGTGATCACCGCCGCCTGGCACCTGCTCACCATGCGGAACGTGCTGCTGGGCGAGGCCA
AGCCCGAGTACCAGGGGCTGGCGGACATCACCCTGAAGGAGAAGATCATCTTCGCCCCGCTGGCCGTGCTGATCGTGTTC
TTCGGCGTATATCCCCGGCCGGTCATGGCTCTTTTGCAGAGCTCTGTTGAAGTGCTGACGCAGGTGATGGGGCTGGGAGG
GATGTAG

Upstream 100 bases:

>100_bases
CTCTCCACCGGGTACGTGCAGCAGTACATGTTCACCTTCCTGGTGATGCTGGTGGCCAGTGTGGTCCTCGTCCAGGTGAT
TAGATAGGAGGCTGTCGGGG

Downstream 100 bases:

>100_bases
GTTGCCGGGAGTCGTCAGTTGGAGCCAACTGGTCAACCCCAGTTACGTGGCCATTCTGCCGCACCTGATCGTCACGGCAA
CCCTCCTGGTCGTCATCGTC

Product: NADH dehydrogenase I subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MLSLIIFVPLVFALVMLFFVPKTQERLLYWLAGIGTLIPFALALVLAAQWPTAEVSTAPYAQGMRFVTHVPWIQAIGVHY
TLGVDGFAFTMLLLSTLLFPLAVLASYGYIKDRVKDYLVLLLILATGTNGVFATLDFMLFYVFWEIVLLPMYFLIGIWGG
ERREYAAIKFFLYTLIGSTVMLVGAIYLYVATGVGTFNLLQMAAASSKLPITGLTTFAFFALLVGFAVKVPMFPFHTWLP
DAHVEAPTPISMLLAGILLKLGSYAMVRISHPMLPQLATKYADLLFVFGVVGILYAALAAMAQKDFKKQVAYSSVNHMGF
FIMALAAASKLAPTSPELAQVALQGGYFVTIAHGLISPLFFFAVGMFYERTHTRDLRKLGGMFLTIPVVSFATAFVAFAN
LGLPGLAGFIGEFISLTGSYPAFGLWVLVAGLGMVITAAWHLLTMRNVLLGEAKPEYQGLADITLKEKIIFAPLAVLIVF
FGVYPRPVMALLQSSVEVLTQVMGLGGM

Sequences:

>Translated_508_residues
MLSLIIFVPLVFALVMLFFVPKTQERLLYWLAGIGTLIPFALALVLAAQWPTAEVSTAPYAQGMRFVTHVPWIQAIGVHY
TLGVDGFAFTMLLLSTLLFPLAVLASYGYIKDRVKDYLVLLLILATGTNGVFATLDFMLFYVFWEIVLLPMYFLIGIWGG
ERREYAAIKFFLYTLIGSTVMLVGAIYLYVATGVGTFNLLQMAAASSKLPITGLTTFAFFALLVGFAVKVPMFPFHTWLP
DAHVEAPTPISMLLAGILLKLGSYAMVRISHPMLPQLATKYADLLFVFGVVGILYAALAAMAQKDFKKQVAYSSVNHMGF
FIMALAAASKLAPTSPELAQVALQGGYFVTIAHGLISPLFFFAVGMFYERTHTRDLRKLGGMFLTIPVVSFATAFVAFAN
LGLPGLAGFIGEFISLTGSYPAFGLWVLVAGLGMVITAAWHLLTMRNVLLGEAKPEYQGLADITLKEKIIFAPLAVLIVF
FGVYPRPVMALLQSSVEVLTQVMGLGGM
>Mature_508_residues
MLSLIIFVPLVFALVMLFFVPKTQERLLYWLAGIGTLIPFALALVLAAQWPTAEVSTAPYAQGMRFVTHVPWIQAIGVHY
TLGVDGFAFTMLLLSTLLFPLAVLASYGYIKDRVKDYLVLLLILATGTNGVFATLDFMLFYVFWEIVLLPMYFLIGIWGG
ERREYAAIKFFLYTLIGSTVMLVGAIYLYVATGVGTFNLLQMAAASSKLPITGLTTFAFFALLVGFAVKVPMFPFHTWLP
DAHVEAPTPISMLLAGILLKLGSYAMVRISHPMLPQLATKYADLLFVFGVVGILYAALAAMAQKDFKKQVAYSSVNHMGF
FIMALAAASKLAPTSPELAQVALQGGYFVTIAHGLISPLFFFAVGMFYERTHTRDLRKLGGMFLTIPVVSFATAFVAFAN
LGLPGLAGFIGEFISLTGSYPAFGLWVLVAGLGMVITAAWHLLTMRNVLLGEAKPEYQGLADITLKEKIIFAPLAVLIVF
FGVYPRPVMALLQSSVEVLTQVMGLGGM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=335, Percent_Identity=31.6417910447761, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI251831117, Length=368, Percent_Identity=25.5434782608696, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1788613, Length=444, Percent_Identity=37.6126126126126, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1788831, Length=294, Percent_Identity=29.2517006802721, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788827, Length=277, Percent_Identity=28.158844765343, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788829, Length=345, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693160, Length=434, Percent_Identity=26.7281105990783, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788614, Length=447, Percent_Identity=26.6219239373602, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=316, Percent_Identity=25.6329113924051, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55430; Mature: 55430

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLIIFVPLVFALVMLFFVPKTQERLLYWLAGIGTLIPFALALVLAAQWPTAEVSTAPY
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AQGMRFVTHVPWIQAIGVHYTLGVDGFAFTMLLLSTLLFPLAVLASYGYIKDRVKDYLVL
HHCCHHHHHCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILATGTNGVFATLDFMLFYVFWEIVLLPMYFLIGIWGGERREYAAIKFFLYTLIGSTV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MLVGAIYLYVATGVGTFNLLQMAAASSKLPITGLTTFAFFALLVGFAVKVPMFPFHTWLP
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCC
DAHVEAPTPISMLLAGILLKLGSYAMVRISHPMLPQLATKYADLLFVFGVVGILYAALAA
CCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAQKDFKKQVAYSSVNHMGFFIMALAAASKLAPTSPELAQVALQGGYFVTIAHGLISPLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEHHHHHHHHHH
FFAVGMFYERTHTRDLRKLGGMFLTIPVVSFATAFVAFANLGLPGLAGFIGEFISLTGSY
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PAFGLWVLVAGLGMVITAAWHLLTMRNVLLGEAKPEYQGLADITLKEKIIFAPLAVLIVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGVYPRPVMALLQSSVEVLTQVMGLGGM
HCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSLIIFVPLVFALVMLFFVPKTQERLLYWLAGIGTLIPFALALVLAAQWPTAEVSTAPY
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AQGMRFVTHVPWIQAIGVHYTLGVDGFAFTMLLLSTLLFPLAVLASYGYIKDRVKDYLVL
HHCCHHHHHCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILATGTNGVFATLDFMLFYVFWEIVLLPMYFLIGIWGGERREYAAIKFFLYTLIGSTV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MLVGAIYLYVATGVGTFNLLQMAAASSKLPITGLTTFAFFALLVGFAVKVPMFPFHTWLP
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCC
DAHVEAPTPISMLLAGILLKLGSYAMVRISHPMLPQLATKYADLLFVFGVVGILYAALAA
CCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAQKDFKKQVAYSSVNHMGFFIMALAAASKLAPTSPELAQVALQGGYFVTIAHGLISPLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEHHHHHHHHHH
FFAVGMFYERTHTRDLRKLGGMFLTIPVVSFATAFVAFANLGLPGLAGFIGEFISLTGSY
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PAFGLWVLVAGLGMVITAAWHLLTMRNVLLGEAKPEYQGLADITLKEKIIFAPLAVLIVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGVYPRPVMALLQSSVEVLTQVMGLGGM
HCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]