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The map label for this gene is nuoL2 [H]

Identifier: 51893907

GI number: 51893907

Start: 2989134

End: 2991191

Strand: Reverse

Name: nuoL2 [H]

Synonym: STH2769

Alternate gene names: 51893907

Gene position: 2991191-2989134 (Counterclockwise)

Preceding gene: 51893908

Following gene: 51893906

Centisome position: 83.88

GC content: 65.55

Gene sequence:

>2058_bases
GTGGACTTCTTCCTGAACACAGCCTGGGTCATCGCTGCGCTCCCCCTGGCCGTCTCCGCACTGATCGCCATGTTCGCCGG
CGTCCTGCGGGACCGGGCGTGGATCCCCGGGACCGTCGGTATGCTGATCACGTTCCTGTGGTCGGTGGGCGTGCTCGCAG
CGGTGATCGCCGATCCGGGGCACGGCGGCGAGGTGCTGTACAACACCGTGCCCGCCTGGAAGGCCTCGTTCGACTGGGCC
AGCTTCGGGCCCTACACGGTGCGCATGGGGTTCCAGGTGGACAACCTGACGGCCCTCATGCTGCCGATGATCACCCTGGT
CTCCGTCTGCGTCCAGTACTACTCCTCCGCCTACATGCACGGCGACAAGCGGATTCCCCGCTTCTACGCGGCGCTGAACC
TGTTCACGATGGCCATGCTGGTGCTGGTCATGGCCGACAACCTCTTTCTGCTGCTGGTGGCGTGGGAGATCATGGGCCTC
TGCTCTTACCTGCTGATCGGTCACTGGTATGAGCAGGCCTGGCCCCGCTACGGCCAGATCAAGGCCTTCCTCACCACCCG
CGTCGGCGACATCGGCATGATGGTCGGCATCTTCATCGTCTTCTTTGCCGCCCGCGACCTGACCTGGGCGGGCCTGGCGG
AGAAGGTGCCGGTTCTGGTGCAGGATCCGGCGACGGCCAGCCTCCTGGCCCTGGGCGCCTTCCTGCTGTTCACCGGCGCG
ATCGGCAAGTCGGCGCAGTTCCCGCTGCACACCTGGCTGCCGGACGCGATGGCCGGCCCGACGCCGGGCTCCGCCATCAT
CCACGCCGCGACGATGGTCGCCGCCGGCGTGTACCTGGTGGGCCGCGCCTTCATGATCTTCGGGCACGTGCCTGCCTGGG
TGCTGGTGGTGGTCACCTTCGTCGGCGCCTTCACGTCGCTGTTCGCCGCCTCCATCGCCACGCTCCGCTGGGACATCAAG
GAGGTCCTCGCCTACTCCACCATCTCCCAGCTGGGCTACATGATTATGGCCATGGGCCTGGGCGGCTGGACGGCGGGCAA
CTTCCACCTGCTCACCCACGCCTTCTTCAAGGCGCTGCTGTTCCTGGCGGCAGGCTCGGTCATCCACGCCCATCACCACA
ACCAGCTGCTGCACAAGATGGGCGGCCTGCGCAAGAAGATCCCGATCACCTTCTGGACCTGGATGGTCGGCTACGCGGCC
CTGGCGGGTATCCCCGGCTTCTCGGGCTTCTTCTCCAAGGACGAGCTGCTGCTCGCGGCCCTGGAATGGCACAACCCGCT
GGTGGCCACCTGGCCGATCTGGCTGCAGAAGCTGCCGTTCGCCATGGCCCTGACGACGGCGTTCCTCACGGCGTACTACA
TGACCCGGGCCACCTACCTGGCGTTCTTCGGCGAGCCGCGGGACATGCACCTGTATGAGCAGGCCCACGAGTCGCCGAAG
GCGATGACGATCCCGCTGATCATCCTGGCCGTTCCGGCGGCGCTCTATGGCTGGCTGGGCACCCCGCTGTTCAACCACTT
CACGAACCTCGACTGGATGGTCTTCATCCAGAACTTCCTGCACCTGCCCGGCCTGGAGCACCATGTCGAGTTCAGCACGG
AGCTGATGGTAACTGGAATGGCCACGGCGGCAGGGCTCCTGGGCATCTTCCTGGGCTGGTACCTGTACGCGGTGGTCCGC
CCGGAGACCCGGGCCGCGTGGATTGCCCGGTTCCGGCCGGTTTACACGCTCGTCCGGAACAAGTATTATGTCGATGAGTT
CTATGATCTCGTCGCCGTCAAGACCACGGAGGCGCTCTCCCGGGCGGTCGCCTGGTTCGACCTCAACGTGGTGGATGGCC
TCGTGAATCTGTCGGGAACCCTGTCGGTGTACGCATCGGAGGCTGCAGCCTGGTTCGACAAGCATGTCGTGGACGCGCTG
GTCAACATGTGGGCCGACATCGCCCGCGCCTTGGGCGCCGCCTTCCGCCGGCTCTCCACCGGGTACGTGCAGCAGTACAT
GTTCACCTTCCTGGTGATGCTGGTGGCCAGTGTGGTCCTCGTCCAGGTGATTAGATAG

Upstream 100 bases:

>100_bases
GCGTCGGTCGGCCTCGCCATCATCCTCGCCATGGTGCGCAACCGCGGCGTGGTCGAGGTCGACAAGGCCACACTGCTGAA
GGGTTAGGAGGGTTGACAGC

Downstream 100 bases:

>100_bases
GAGGCTGTCGGGGATGCTGTCGCTAATCATCTTTGTACCCCTGGTCTTCGCCCTCGTGATGCTGTTCTTTGTGCCGAAGA
CCCAGGAGCGGCTCCTGTAC

Product: NADH dehydrogenase I subunit L

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 5; NDH-1, chain 5 [H]

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MDFFLNTAWVIAALPLAVSALIAMFAGVLRDRAWIPGTVGMLITFLWSVGVLAAVIADPGHGGEVLYNTVPAWKASFDWA
SFGPYTVRMGFQVDNLTALMLPMITLVSVCVQYYSSAYMHGDKRIPRFYAALNLFTMAMLVLVMADNLFLLLVAWEIMGL
CSYLLIGHWYEQAWPRYGQIKAFLTTRVGDIGMMVGIFIVFFAARDLTWAGLAEKVPVLVQDPATASLLALGAFLLFTGA
IGKSAQFPLHTWLPDAMAGPTPGSAIIHAATMVAAGVYLVGRAFMIFGHVPAWVLVVVTFVGAFTSLFAASIATLRWDIK
EVLAYSTISQLGYMIMAMGLGGWTAGNFHLLTHAFFKALLFLAAGSVIHAHHHNQLLHKMGGLRKKIPITFWTWMVGYAA
LAGIPGFSGFFSKDELLLAALEWHNPLVATWPIWLQKLPFAMALTTAFLTAYYMTRATYLAFFGEPRDMHLYEQAHESPK
AMTIPLIILAVPAALYGWLGTPLFNHFTNLDWMVFIQNFLHLPGLEHHVEFSTELMVTGMATAAGLLGIFLGWYLYAVVR
PETRAAWIARFRPVYTLVRNKYYVDEFYDLVAVKTTEALSRAVAWFDLNVVDGLVNLSGTLSVYASEAAAWFDKHVVDAL
VNMWADIARALGAAFRRLSTGYVQQYMFTFLVMLVASVVLVQVIR

Sequences:

>Translated_685_residues
MDFFLNTAWVIAALPLAVSALIAMFAGVLRDRAWIPGTVGMLITFLWSVGVLAAVIADPGHGGEVLYNTVPAWKASFDWA
SFGPYTVRMGFQVDNLTALMLPMITLVSVCVQYYSSAYMHGDKRIPRFYAALNLFTMAMLVLVMADNLFLLLVAWEIMGL
CSYLLIGHWYEQAWPRYGQIKAFLTTRVGDIGMMVGIFIVFFAARDLTWAGLAEKVPVLVQDPATASLLALGAFLLFTGA
IGKSAQFPLHTWLPDAMAGPTPGSAIIHAATMVAAGVYLVGRAFMIFGHVPAWVLVVVTFVGAFTSLFAASIATLRWDIK
EVLAYSTISQLGYMIMAMGLGGWTAGNFHLLTHAFFKALLFLAAGSVIHAHHHNQLLHKMGGLRKKIPITFWTWMVGYAA
LAGIPGFSGFFSKDELLLAALEWHNPLVATWPIWLQKLPFAMALTTAFLTAYYMTRATYLAFFGEPRDMHLYEQAHESPK
AMTIPLIILAVPAALYGWLGTPLFNHFTNLDWMVFIQNFLHLPGLEHHVEFSTELMVTGMATAAGLLGIFLGWYLYAVVR
PETRAAWIARFRPVYTLVRNKYYVDEFYDLVAVKTTEALSRAVAWFDLNVVDGLVNLSGTLSVYASEAAAWFDKHVVDAL
VNMWADIARALGAAFRRLSTGYVQQYMFTFLVMLVASVVLVQVIR
>Mature_685_residues
MDFFLNTAWVIAALPLAVSALIAMFAGVLRDRAWIPGTVGMLITFLWSVGVLAAVIADPGHGGEVLYNTVPAWKASFDWA
SFGPYTVRMGFQVDNLTALMLPMITLVSVCVQYYSSAYMHGDKRIPRFYAALNLFTMAMLVLVMADNLFLLLVAWEIMGL
CSYLLIGHWYEQAWPRYGQIKAFLTTRVGDIGMMVGIFIVFFAARDLTWAGLAEKVPVLVQDPATASLLALGAFLLFTGA
IGKSAQFPLHTWLPDAMAGPTPGSAIIHAATMVAAGVYLVGRAFMIFGHVPAWVLVVVTFVGAFTSLFAASIATLRWDIK
EVLAYSTISQLGYMIMAMGLGGWTAGNFHLLTHAFFKALLFLAAGSVIHAHHHNQLLHKMGGLRKKIPITFWTWMVGYAA
LAGIPGFSGFFSKDELLLAALEWHNPLVATWPIWLQKLPFAMALTTAFLTAYYMTRATYLAFFGEPRDMHLYEQAHESPK
AMTIPLIILAVPAALYGWLGTPLFNHFTNLDWMVFIQNFLHLPGLEHHVEFSTELMVTGMATAAGLLGIFLGWYLYAVVR
PETRAAWIARFRPVYTLVRNKYYVDEFYDLVAVKTTEALSRAVAWFDLNVVDGLVNLSGTLSVYASEAAAWFDKHVVDAL
VNMWADIARALGAAFRRLSTGYVQQYMFTFLVMLVASVVLVQVIR

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=428, Percent_Identity=35.2803738317757, Blast_Score=232, Evalue=7e-61,
Organism=Escherichia coli, GI1788614, Length=465, Percent_Identity=44.0860215053763, Blast_Score=315, Evalue=9e-87,
Organism=Escherichia coli, GI1788829, Length=342, Percent_Identity=33.0409356725146, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1788827, Length=482, Percent_Identity=29.045643153527, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788831, Length=353, Percent_Identity=28.0453257790368, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI2367154, Length=425, Percent_Identity=24.9411764705882, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788613, Length=383, Percent_Identity=24.0208877284595, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=254, Percent_Identity=24.8031496062992, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: 1.6.5.3

Molecular weight: Translated: 75884; Mature: 75884

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFFLNTAWVIAALPLAVSALIAMFAGVLRDRAWIPGTVGMLITFLWSVGVLAAVIADPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HGGEVLYNTVPAWKASFDWASFGPYTVRMGFQVDNLTALMLPMITLVSVCVQYYSSAYMH
CCCCEEEECCCCCCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDKRIPRFYAALNLFTMAMLVLVMADNLFLLLVAWEIMGLCSYLLIGHWYEQAWPRYGQI
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KAFLTTRVGDIGMMVGIFIVFFAARDLTWAGLAEKVPVLVQDPATASLLALGAFLLFTGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCCEEEECCCHHHHHHHHHHHHHHHC
IGKSAQFPLHTWLPDAMAGPTPGSAIIHAATMVAAGVYLVGRAFMIFGHVPAWVLVVVTF
CCCCCCCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAFTSLFAASIATLRWDIKEVLAYSTISQLGYMIMAMGLGGWTAGNFHLLTHAFFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FLAAGSVIHAHHHNQLLHKMGGLRKKIPITFWTWMVGYAALAGIPGFSGFFSKDELLLAA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LEWHNPLVATWPIWLQKLPFAMALTTAFLTAYYMTRATYLAFFGEPRDMHLYEQAHESPK
HHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
AMTIPLIILAVPAALYGWLGTPLFNHFTNLDWMVFIQNFLHLPGLEHHVEFSTELMVTGM
CCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHH
ATAAGLLGIFLGWYLYAVVRPETRAAWIARFRPVYTLVRNKYYVDEFYDLVAVKTTEALS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RAVAWFDLNVVDGLVNLSGTLSVYASEAAAWFDKHVVDALVNMWADIARALGAAFRRLST
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYVQQYMFTFLVMLVASVVLVQVIR
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFFLNTAWVIAALPLAVSALIAMFAGVLRDRAWIPGTVGMLITFLWSVGVLAAVIADPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HGGEVLYNTVPAWKASFDWASFGPYTVRMGFQVDNLTALMLPMITLVSVCVQYYSSAYMH
CCCCEEEECCCCCCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDKRIPRFYAALNLFTMAMLVLVMADNLFLLLVAWEIMGLCSYLLIGHWYEQAWPRYGQI
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KAFLTTRVGDIGMMVGIFIVFFAARDLTWAGLAEKVPVLVQDPATASLLALGAFLLFTGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCCEEEECCCHHHHHHHHHHHHHHHC
IGKSAQFPLHTWLPDAMAGPTPGSAIIHAATMVAAGVYLVGRAFMIFGHVPAWVLVVVTF
CCCCCCCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAFTSLFAASIATLRWDIKEVLAYSTISQLGYMIMAMGLGGWTAGNFHLLTHAFFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FLAAGSVIHAHHHNQLLHKMGGLRKKIPITFWTWMVGYAALAGIPGFSGFFSKDELLLAA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LEWHNPLVATWPIWLQKLPFAMALTTAFLTAYYMTRATYLAFFGEPRDMHLYEQAHESPK
HHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
AMTIPLIILAVPAALYGWLGTPLFNHFTNLDWMVFIQNFLHLPGLEHHVEFSTELMVTGM
CCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHH
ATAAGLLGIFLGWYLYAVVRPETRAAWIARFRPVYTLVRNKYYVDEFYDLVAVKTTEALS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RAVAWFDLNVVDGLVNLSGTLSVYASEAAAWFDKHVVDALVNMWADIARALGAAFRRLST
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYVQQYMFTFLVMLVASVVLVQVIR
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8501038; 1554697 [H]