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The map label for this gene is nuoN2

Identifier: 51893905

GI number: 51893905

Start: 2986066

End: 2987592

Strand: Reverse

Name: nuoN2

Synonym: STH2767

Alternate gene names: 51893905

Gene position: 2987592-2986066 (Counterclockwise)

Preceding gene: 51893906

Following gene: 51893903

Centisome position: 83.78

GC content: 66.93

Gene sequence:

>1527_bases
TTGCCGGGAGTCGTCAGTTGGAGCCAACTGGTCAACCCCAGTTACGTGGCCATTCTGCCGCACCTGATCGTCACGGCAAC
CCTCCTGGTCGTCATCGTCCTGGATGCCTACTTCAAGGAGAAGCGGAGCCTGGTCTGGGTGACGCTGGGCGGCGTGGTTC
TGGCGATGCTGTCCATTTGGTACACCGCCAGCGACCCGCAGATCCAGGCGGGCATTGCCGCAGGACGGCCGCCGGAGTTC
TGGGGCGGCATGATCATCGCCGACGGGTTCACCTTCTTCATGAACGGCGTGCTGCTCGGCATCGCCGCCCTGGTGATCCT
GCTGTCGGCGGACTACGTGGGCAAGTTCCTGCGCGGGGCGCACATGGAGTTCTATGAGATCATCCTGGCGGTGACGCTGG
GCATGATGTTCATGGTGTCCTCCCGCGATCTGCTCACCATCTACATCGGCCTGGAGCTCACGTCCATCTCCTCGTACGTG
CTGGCGGGCATCCTGCGCAAGGATGCCAAGTCCAACGAGGCCGCCCTGAAGTACTTCCTCACCGGCGCCACCGCCTCGGC
CGTCCTGCTCTTCGGCCTGTCGCTGATCTACGGCGTGACCGGTAGCACGCGGCTGCCCGAGGTCGCGGCGGCCCTCGCCG
GAGGCAGCCACGTGGTGGCCGCGGCCGGCCCGGCTCTGACGCCCCTTCTGGTGGCAGGGATGGCCTTCCTGATGGTGGGC
TTCGGCTTCAAGGTGGCGGCGGTGCCGGTGCACCAGTGGGCCCCGGACGTCTACGAGGGCGCGCCCACGCCGGTTACGGC
GTTCTTCTCCGCCGGCCCCAAGGGGGCAGCCATGGCGGCCATCCTCCGGGTCTTCGTCGGCGGGCTGGGCGTGGCGCCGT
TCACCGACAAGTGGGCCCTCATCTGGGCCCTGGCCGCGGCGGCCTCGATGACCGTGGGCAACCTGGTGGCCCTGCAGCAG
ACCAACATCAAGCGCATGATGGCGTACTCCTCCATCGCTCAGGCCGGGTACATCCTGGTGGGCGTGGCGGCCTCGGGGCT
GCAGTCCGTCGAGGGGATCTCGTCGGTGCTCTTCTACGTGATGGCCTACGCCGTGACCAACCTCGGCATCTTCGCCGTCC
TCACCCACATGGACCAGGAGGGCGGCTGGGTGGAGGTGGACAACTACGCGGGGCTGGCCAAGCGGAACCCGCTGTACGCC
TGGGCGCTGCTGCTGTTCTTCGTCTCCCTGATCGGCATCCCGCCGACGGTGGGCTTCCTGGGCAAGTTCTTCCTGTTCCG
GGCGGCCGCCGCATCCGGATATCTCTGGCTGGCGGTGCTCATGGCGGTCAACTCCGTCATCTCCGTGGGCTACTACTACC
GGGTGGTCAAGGTCATGTTCCTGGACCAGTCCGACTACCCGGCGCTCACGCCCAGCACGGGCATCTCCGCCACCGTTCTG
CTGTCCCTGCTGGGGGTTGTGGCGCTGACCATCTTCGCCAACCCGTTCGTGCAGTGGACGGCGCAGTCCGCGGCGCTGCT
GCATTAG

Upstream 100 bases:

>100_bases
CTGATCGTGTTCTTCGGCGTATATCCCCGGCCGGTCATGGCTCTTTTGCAGAGCTCTGTTGAAGTGCTGACGCAGGTGAT
GGGGCTGGGAGGGATGTAGG

Downstream 100 bases:

>100_bases
ACCGAAAGCGCAGAAGAAGGGCCGGGAGCGGCAGGCTCCCGGCCCTGATCATTTATGGAAACTGCACGTAGCGTGTGCCT
CAGTCCGCCGAGGAGCCCAT

Product: NADH dehydrogenase I subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 2; NDH-1 subunit N 2

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MPGVVSWSQLVNPSYVAILPHLIVTATLLVVIVLDAYFKEKRSLVWVTLGGVVLAMLSIWYTASDPQIQAGIAAGRPPEF
WGGMIIADGFTFFMNGVLLGIAALVILLSADYVGKFLRGAHMEFYEIILAVTLGMMFMVSSRDLLTIYIGLELTSISSYV
LAGILRKDAKSNEAALKYFLTGATASAVLLFGLSLIYGVTGSTRLPEVAAALAGGSHVVAAAGPALTPLLVAGMAFLMVG
FGFKVAAVPVHQWAPDVYEGAPTPVTAFFSAGPKGAAMAAILRVFVGGLGVAPFTDKWALIWALAAAASMTVGNLVALQQ
TNIKRMMAYSSIAQAGYILVGVAASGLQSVEGISSVLFYVMAYAVTNLGIFAVLTHMDQEGGWVEVDNYAGLAKRNPLYA
WALLLFFVSLIGIPPTVGFLGKFFLFRAAAASGYLWLAVLMAVNSVISVGYYYRVVKVMFLDQSDYPALTPSTGISATVL
LSLLGVVALTIFANPFVQWTAQSAALLH

Sequences:

>Translated_508_residues
MPGVVSWSQLVNPSYVAILPHLIVTATLLVVIVLDAYFKEKRSLVWVTLGGVVLAMLSIWYTASDPQIQAGIAAGRPPEF
WGGMIIADGFTFFMNGVLLGIAALVILLSADYVGKFLRGAHMEFYEIILAVTLGMMFMVSSRDLLTIYIGLELTSISSYV
LAGILRKDAKSNEAALKYFLTGATASAVLLFGLSLIYGVTGSTRLPEVAAALAGGSHVVAAAGPALTPLLVAGMAFLMVG
FGFKVAAVPVHQWAPDVYEGAPTPVTAFFSAGPKGAAMAAILRVFVGGLGVAPFTDKWALIWALAAAASMTVGNLVALQQ
TNIKRMMAYSSIAQAGYILVGVAASGLQSVEGISSVLFYVMAYAVTNLGIFAVLTHMDQEGGWVEVDNYAGLAKRNPLYA
WALLLFFVSLIGIPPTVGFLGKFFLFRAAAASGYLWLAVLMAVNSVISVGYYYRVVKVMFLDQSDYPALTPSTGISATVL
LSLLGVVALTIFANPFVQWTAQSAALLH
>Mature_507_residues
PGVVSWSQLVNPSYVAILPHLIVTATLLVVIVLDAYFKEKRSLVWVTLGGVVLAMLSIWYTASDPQIQAGIAAGRPPEFW
GGMIIADGFTFFMNGVLLGIAALVILLSADYVGKFLRGAHMEFYEIILAVTLGMMFMVSSRDLLTIYIGLELTSISSYVL
AGILRKDAKSNEAALKYFLTGATASAVLLFGLSLIYGVTGSTRLPEVAAALAGGSHVVAAAGPALTPLLVAGMAFLMVGF
GFKVAAVPVHQWAPDVYEGAPTPVTAFFSAGPKGAAMAAILRVFVGGLGVAPFTDKWALIWALAAAASMTVGNLVALQQT
NIKRMMAYSSIAQAGYILVGVAASGLQSVEGISSVLFYVMAYAVTNLGIFAVLTHMDQEGGWVEVDNYAGLAKRNPLYAW
ALLLFFVSLIGIPPTVGFLGKFFLFRAAAASGYLWLAVLMAVNSVISVGYYYRVVKVMFLDQSDYPALTPSTGISATVLL
SLLGVVALTIFANPFVQWTAQSAALLH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831117, Length=377, Percent_Identity=24.1379310344828, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI145693160, Length=499, Percent_Identity=32.6653306613226, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1788831, Length=403, Percent_Identity=27.0471464019851, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788614, Length=398, Percent_Identity=25.6281407035176, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788827, Length=459, Percent_Identity=26.797385620915, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788829, Length=338, Percent_Identity=24.8520710059172, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON2_SYMTH (Q67KP6)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076596.1
- GeneID:   2979578
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2767
- NMPDR:   fig|292459.1.peg.2644
- HOGENOM:   HBG747830
- OMA:   ILMTITI
- BioCyc:   STHE292459:STH2767-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 53747; Mature: 53616

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfa50658)-; HASH(0x156704bc)-; HASH(0x14ba2cb4)-; HASH(0x1490d708)-; HASH(0x1567048c)-; HASH(0x156789c4)-; HASH(0x154851cc)-; HASH(0xfa91e04)-; HASH(0x15485268)-; HASH(0x156704f8)-; HASH(0x13c5a0ec)-; HASH(0x156706a8)-; HASH(0x15091dcc)-; HASH(0x150895d0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVVSWSQLVNPSYVAILPHLIVTATLLVVIVLDAYFKEKRSLVWVTLGGVVLAMLSIW
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHH
YTASDPQIQAGIAAGRPPEFWGGMIIADGFTFFMNGVLLGIAALVILLSADYVGKFLRGA
HCCCCCCEEECCCCCCCCHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HMEFYEIILAVTLGMMFMVSSRDLLTIYIGLELTSISSYVLAGILRKDAKSNEAALKYFL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHH
TGATASAVLLFGLSLIYGVTGSTRLPEVAAALAGGSHVVAAAGPALTPLLVAGMAFLMVG
HCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
FGFKVAAVPVHQWAPDVYEGAPTPVTAFFSAGPKGAAMAAILRVFVGGLGVAPFTDKWAL
CCCEEEEEEHHHCCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
IWALAAAASMTVGNLVALQQTNIKRMMAYSSIAQAGYILVGVAASGLQSVEGISSVLFYV
HHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHH
MAYAVTNLGIFAVLTHMDQEGGWVEVDNYAGLAKRNPLYAWALLLFFVSLIGIPPTVGFL
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
GKFFLFRAAAASGYLWLAVLMAVNSVISVGYYYRVVKVMFLDQSDYPALTPSTGISATVL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHH
LSLLGVVALTIFANPFVQWTAQSAALLH
HHHHHHHHHHHHHCHHHHHHCCHHHCCH
>Mature Secondary Structure 
PGVVSWSQLVNPSYVAILPHLIVTATLLVVIVLDAYFKEKRSLVWVTLGGVVLAMLSIW
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHH
YTASDPQIQAGIAAGRPPEFWGGMIIADGFTFFMNGVLLGIAALVILLSADYVGKFLRGA
HCCCCCCEEECCCCCCCCHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HMEFYEIILAVTLGMMFMVSSRDLLTIYIGLELTSISSYVLAGILRKDAKSNEAALKYFL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHH
TGATASAVLLFGLSLIYGVTGSTRLPEVAAALAGGSHVVAAAGPALTPLLVAGMAFLMVG
HCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
FGFKVAAVPVHQWAPDVYEGAPTPVTAFFSAGPKGAAMAAILRVFVGGLGVAPFTDKWAL
CCCEEEEEEHHHCCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
IWALAAAASMTVGNLVALQQTNIKRMMAYSSIAQAGYILVGVAASGLQSVEGISSVLFYV
HHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHH
MAYAVTNLGIFAVLTHMDQEGGWVEVDNYAGLAKRNPLYAWALLLFFVSLIGIPPTVGFL
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
GKFFLFRAAAASGYLWLAVLMAVNSVISVGYYYRVVKVMFLDQSDYPALTPSTGISATVL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHH
LSLLGVVALTIFANPFVQWTAQSAALLH
HHHHHHHHHHHHHCHHHHHHCCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA