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The map label for this gene is mvaA

Identifier: 51598940

GI number: 51598940

Start: 728404

End: 729678

Strand: Direct

Name: mvaA

Synonym: BG0708

Alternate gene names: NA

Gene position: 728404-729678 (Clockwise)

Preceding gene: 51598939

Following gene: 51598941

Centisome position: 80.55

GC content: 29.02

Gene sequence:

>1275_bases
ATGAAACTTAGTAAAAATTTTAGGCATAAAAGTGTTTTAGAAAAAAGGCAAGAGATAAAAAGTTTTTTGGGATTATCTTT
TAAAGATTTTTTTTATAATAATGCCAATGAAGATTTTCTTTTTAATATGATAGAAAATTATATTGGATATTTATCTTTTC
CTATTGGAATCGTAAAAAATTTGAAAATAAATGGTAAATACTATTCTTTGCCTATTGCAACAGAAGAATCTTCTGTGGTT
GCTGCCTTAAATTTTGCGGCAAAAATTCTTGAAAATGCTAATTTGAAGTATTCTTTGGGCGAAGTATTGGGAATTTCTCA
AATTTATATAAAAACGGAAAAAGATTTAAGTAAAATTTTTGTTGATCTTAGTGATAAAATCAAGACCTGGATTGAACCTC
TTTTGGTCAATATGAATCAAAGAGGAGGTGGATTTAGAAGATTATCAACTAGGTATATTAAAGAGCTTGGTATTCAAAAA
TTTAATCTTTATTTGGATACCTGTGATGCTATGGGTGCTAATTTACTAAACTCAATTGCAGAGCGTGTAGCAGAATGTAT
TTTTTTAGAATTTGGATATGAGTGCGTTTTAAAAGTTTTAAGCAATGATATTAATGAATTTACAACCAAAGCCTCTTTTG
TTTTAGATTTTAAGCATTTGCTACCAAATAAAGAGGAGTCTTGGAATTTGGCTAAAAAAATTGAACTTATTTCTAGTATA
GGTTTCTACGAAGAGGAGCGAGCTGTTACTAATAATAAAGGTATTATGAATGGAATTACGGGAGTATGTCTTGCAACTTT
TAATGATACAAGAGCGCTTGAGGCCTCTGCTCACAGATTTGCTTCAAAAAGTGGTAAATATCTTCCTCTTAGTAAATTTT
ATACTATTGATAATGCTTTGGTTGGAGAAATCGAAATTCCTTTGCAAGTTGGCACTAAGGGTGGGGTTACATCTTTTAGC
GAAGCTTCAATTTTAAGTTTTAGAATTATGAATGTAAATAGTAAGAGTGAATTTATGGGCATTCTCTCTTGCGTTGGACT
TGCTAGTAATTTTGCTGCATTAAGAGCTCTTGCATTTAACGGGATTAAAAAGGGTCATATGAGATTACATGTTAATAAAA
TACTTTACCTTTTAAAGACAAAATATAATATTTCTAATTTCGAGAAAGACAAATTATTATTAGAAATGGAAAGAATGGAT
ATTTATTCTTTTGATTTTGCTTTTCAAATTTTAAAGAAAATAAGGTTAGAGAATGAAAGTAAAGTGCAAAGTTAA

Upstream 100 bases:

>100_bases
ATGTTTTTAAGTGGAAGTAAAAGTTTGTCAGAACTTAGAAAAAATAAGTATTTTTTGAGTAGCTATTTACTTGCAGAGCT
TGGAGTTTTTAAGCAGTTTT

Downstream 100 bases:

>100_bases
TGCAAGCTTAGCTTTAATTAAATATTGGGGCAAGAAGGATGCTTTTTTAAACATTCCAGCGACTTCTAGTCTTGCCGTTA
GTGTTGATAAATTTTATTCA

Product: 3-hydroxy-3-methylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKLSKNFRHKSVLEKRQEIKSFLGLSFKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVV
AALNFAAKILENANLKYSLGEVLGISQIYIKTEKDLSKIFVDLSDKIKTWIEPLLVNMNQRGGGFRRLSTRYIKELGIQK
FNLYLDTCDAMGANLLNSIAERVAECIFLEFGYECVLKVLSNDINEFTTKASFVLDFKHLLPNKEESWNLAKKIELISSI
GFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASAHRFASKSGKYLPLSKFYTIDNALVGEIEIPLQVGTKGGVTSFS
EASILSFRIMNVNSKSEFMGILSCVGLASNFAALRALAFNGIKKGHMRLHVNKILYLLKTKYNISNFEKDKLLLEMERMD
IYSFDFAFQILKKIRLENESKVQS

Sequences:

>Translated_424_residues
MKLSKNFRHKSVLEKRQEIKSFLGLSFKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVV
AALNFAAKILENANLKYSLGEVLGISQIYIKTEKDLSKIFVDLSDKIKTWIEPLLVNMNQRGGGFRRLSTRYIKELGIQK
FNLYLDTCDAMGANLLNSIAERVAECIFLEFGYECVLKVLSNDINEFTTKASFVLDFKHLLPNKEESWNLAKKIELISSI
GFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASAHRFASKSGKYLPLSKFYTIDNALVGEIEIPLQVGTKGGVTSFS
EASILSFRIMNVNSKSEFMGILSCVGLASNFAALRALAFNGIKKGHMRLHVNKILYLLKTKYNISNFEKDKLLLEMERMD
IYSFDFAFQILKKIRLENESKVQS
>Mature_424_residues
MKLSKNFRHKSVLEKRQEIKSFLGLSFKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVV
AALNFAAKILENANLKYSLGEVLGISQIYIKTEKDLSKIFVDLSDKIKTWIEPLLVNMNQRGGGFRRLSTRYIKELGIQK
FNLYLDTCDAMGANLLNSIAERVAECIFLEFGYECVLKVLSNDINEFTTKASFVLDFKHLLPNKEESWNLAKKIELISSI
GFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASAHRFASKSGKYLPLSKFYTIDNALVGEIEIPLQVGTKGGVTSFS
EASILSFRIMNVNSKSEFMGILSCVGLASNFAALRALAFNGIKKGHMRLHVNKILYLLKTKYNISNFEKDKLLLEMERMD
IYSFDFAFQILKKIRLENESKVQS

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 48125; Mature: 48125

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSKNFRHKSVLEKRQEIKSFLGLSFKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKN
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LKINGKYYSLPIATEESSVVAALNFAAKILENANLKYSLGEVLGISQIYIKTEKDLSKIF
EEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEHHHHHCCCCEEEECHHHHHHHH
VDLSDKIKTWIEPLLVNMNQRGGGFRRLSTRYIKELGIQKFNLYLDTCDAMGANLLNSIA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEECHHHHHHHHHHHHH
ERVAECIFLEFGYECVLKVLSNDINEFTTKASFVLDFKHLLPNKEESWNLAKKIELISSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCCHHHHHHHHHHC
GFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASAHRFASKSGKYLPLSKFYTIDNAL
CCCHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHEEEECCCE
VGEIEIPLQVGTKGGVTSFSEASILSFRIMNVNSKSEFMGILSCVGLASNFAALRALAFN
EEEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKKGHMRLHVNKILYLLKTKYNISNFEKDKLLLEMERMDIYSFDFAFQILKKIRLENES
CCCCCCCEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHH
KVQS
CCCC
>Mature Secondary Structure
MKLSKNFRHKSVLEKRQEIKSFLGLSFKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKN
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LKINGKYYSLPIATEESSVVAALNFAAKILENANLKYSLGEVLGISQIYIKTEKDLSKIF
EEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEHHHHHCCCCEEEECHHHHHHHH
VDLSDKIKTWIEPLLVNMNQRGGGFRRLSTRYIKELGIQKFNLYLDTCDAMGANLLNSIA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEECHHHHHHHHHHHHH
ERVAECIFLEFGYECVLKVLSNDINEFTTKASFVLDFKHLLPNKEESWNLAKKIELISSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCCHHHHHHHHHHC
GFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASAHRFASKSGKYLPLSKFYTIDNAL
CCCHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHEEEECCCE
VGEIEIPLQVGTKGGVTSFSEASILSFRIMNVNSKSEFMGILSCVGLASNFAALRALAFN
EEEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKKGHMRLHVNKILYLLKTKYNISNFEKDKLLLEMERMDIYSFDFAFQILKKIRLENES
CCCCCCCEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHH
KVQS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]