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The map label for this gene is gnd [H]

Identifier: 51598812

GI number: 51598812

Start: 575829

End: 577223

Strand: Direct

Name: gnd [H]

Synonym: BG0571

Alternate gene names: 51598812

Gene position: 575829-577223 (Clockwise)

Preceding gene: 51598810

Following gene: 51598816

Centisome position: 63.68

GC content: 30.9

Gene sequence:

>1395_bases
ATGGATGTAGGAATTTATGGTCTTGGTGTTATGGGCGGCAATTTAGCTCTAAATATTGCTGATAACGGTTTTAATGTTTC
TGTTTACAATAGAGATAGTGAAAAAACTGAAATTTTTGTTAAACAAAATTCTCATAAAAAGATAAATGGCTTTAAAGATG
TTGAATCTTTTGTTAAAAGCTTAAAACCCCCAAGAAAAATCATTTTAATGGTGACAAGTTTAGCTGTAGAAAAGGTTGTT
GAACAAATTTTACCCCTTTTGAATAAATCGGACATAATTATTGATGGTGGGAATTCTCATTATAAGAATACAATGAGAAT
AGAAAAAGAATTGTTTGCCAAGGACATTTATTTTGTAGGGCTTGGAATTTCTGGAGGAGAGAGGGGTGCAAGATTTGGTC
CTGCTCTAATGTATGGAGGCAGTAAATCAGCTTATGAAATTCTTGAGCCTATTTTAAATAAAATTGCAGCTAAAACTAAA
AACAACGATGTTTGTTCGACTTATATTGGAGAGAATGGTTCTGGACACTATGTTAAAATGATACATAATGGGGTTGAATA
CGCTGATATGCAGCTTATTAGCGAGGTTTATTTCTTCATGAAAAAAGCTTTCAATTTAGATAATTCAAAAATTTCTGAAG
TTTTTGAAAAATGGAATGAAGGCGATCTTTCAGGGTATTTGCTAGAAATAACTTCTAAGATTCTTAGGTATAAAGAAAAT
AATGAATATTTAGTTGATAAGATTTTAGATGTTGCAAATCAAAAAGGTACTGGTGTTTGGACATCTATTGATGCTCTTGA
ATCTAGCATGCCTGTAAATTTAATTCTTGAATCTGTTTTTTCAAGATTTATGTCGGGGCTAAAACACGAAAGGATTATTG
CTAGTGATTTGCTTAAGATGGATACTGCTTCTTTTGAGTTTGAGCTTAGCGATTGGATTTTAGATCTTTATTATGCTCTT
TTGGTTTCAAAAATAGTAGCTTATGCCCAAGGTTTTATGATGCTTAAGACCGCATCTGTAAATTATAGTTGGGATTTAAA
TTTGGGTAAAATTTCTTTAGTTTGGAGAGAAGGCTGTATTATTCGTAGCAGTTTTTTAGACAAAATTAAATTAGCTTATG
ATAAAAATCCCCATCTTATTAATTTGCTTTTTGATGATTATTTTTTGGATTTATTAAAAAATAATCACAAATCTTTGAGA
AGAATAGTTTCAAAGGCTAGTGAAATTGGGATTCCTTTGCCAGCATTTTATGCCAGTCTTTCATTTTTAGATTCTTATTC
CACTAATTATTTGCCTTCTAATCTAATTCAAGCACAAAGAGACTTTTTTGGTGCCCATTCTTTTGAAAGATTAGACTCAA
AACGAGGTGAATTTTTTCATAGTATTTGGCAATAA

Upstream 100 bases:

>100_bases
TTTCAATTTAATCTTTACTTTTTTTATAATATAACATAATCTAAAAATAATAAATAAAGCAATTTGTTTAAAATAGAAAA
TTAGAATCAAGGAGAATGCA

Downstream 100 bases:

>100_bases
ATTTTAAATTTAATGAATCACTATGTGGATTTAGATATAGTACTTAGCGAATATTCCCCCAGTAAAGTTTGATTTTATGC
CTGAATAGGTTTTATGGTGT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MDVGIYGLGVMGGNLALNIADNGFNVSVYNRDSEKTEIFVKQNSHKKINGFKDVESFVKSLKPPRKIILMVTSLAVEKVV
EQILPLLNKSDIIIDGGNSHYKNTMRIEKELFAKDIYFVGLGISGGERGARFGPALMYGGSKSAYEILEPILNKIAAKTK
NNDVCSTYIGENGSGHYVKMIHNGVEYADMQLISEVYFFMKKAFNLDNSKISEVFEKWNEGDLSGYLLEITSKILRYKEN
NEYLVDKILDVANQKGTGVWTSIDALESSMPVNLILESVFSRFMSGLKHERIIASDLLKMDTASFEFELSDWILDLYYAL
LVSKIVAYAQGFMMLKTASVNYSWDLNLGKISLVWREGCIIRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLR
RIVSKASEIGIPLPAFYASLSFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSIWQ

Sequences:

>Translated_464_residues
MDVGIYGLGVMGGNLALNIADNGFNVSVYNRDSEKTEIFVKQNSHKKINGFKDVESFVKSLKPPRKIILMVTSLAVEKVV
EQILPLLNKSDIIIDGGNSHYKNTMRIEKELFAKDIYFVGLGISGGERGARFGPALMYGGSKSAYEILEPILNKIAAKTK
NNDVCSTYIGENGSGHYVKMIHNGVEYADMQLISEVYFFMKKAFNLDNSKISEVFEKWNEGDLSGYLLEITSKILRYKEN
NEYLVDKILDVANQKGTGVWTSIDALESSMPVNLILESVFSRFMSGLKHERIIASDLLKMDTASFEFELSDWILDLYYAL
LVSKIVAYAQGFMMLKTASVNYSWDLNLGKISLVWREGCIIRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLR
RIVSKASEIGIPLPAFYASLSFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSIWQ
>Mature_464_residues
MDVGIYGLGVMGGNLALNIADNGFNVSVYNRDSEKTEIFVKQNSHKKINGFKDVESFVKSLKPPRKIILMVTSLAVEKVV
EQILPLLNKSDIIIDGGNSHYKNTMRIEKELFAKDIYFVGLGISGGERGARFGPALMYGGSKSAYEILEPILNKIAAKTK
NNDVCSTYIGENGSGHYVKMIHNGVEYADMQLISEVYFFMKKAFNLDNSKISEVFEKWNEGDLSGYLLEITSKILRYKEN
NEYLVDKILDVANQKGTGVWTSIDALESSMPVNLILESVFSRFMSGLKHERIIASDLLKMDTASFEFELSDWILDLYYAL
LVSKIVAYAQGFMMLKTASVNYSWDLNLGKISLVWREGCIIRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLR
RIVSKASEIGIPLPAFYASLSFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSIWQ

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=466, Percent_Identity=47.8540772532189, Blast_Score=432, Evalue=1e-121,
Organism=Escherichia coli, GI1788341, Length=463, Percent_Identity=48.3801295896328, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17542558, Length=468, Percent_Identity=46.7948717948718, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321695, Length=455, Percent_Identity=48.5714285714286, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=48.3516483516484, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=46.2365591397849, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52574; Mature: 52574

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVGIYGLGVMGGNLALNIADNGFNVSVYNRDSEKTEIFVKQNSHKKINGFKDVESFVKS
CCCCEEEEEEECCCEEEEEECCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHH
LKPPRKIILMVTSLAVEKVVEQILPLLNKSDIIIDGGNSHYKNTMRIEKELFAKDIYFVG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEE
LGISGGERGARFGPALMYGGSKSAYEILEPILNKIAAKTKNNDVCSTYIGENGSGHYVKM
EECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCEEEE
IHNGVEYADMQLISEVYFFMKKAFNLDNSKISEVFEKWNEGDLSGYLLEITSKILRYKEN
ECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
NEYLVDKILDVANQKGTGVWTSIDALESSMPVNLILESVFSRFMSGLKHERIIASDLLKM
CCHHHHHHHHHHCCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DTASFEFELSDWILDLYYALLVSKIVAYAQGFMMLKTASVNYSWDLNLGKISLVWREGCI
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCEEEEEEECCCE
IRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLRRIVSKASEIGIPLPAFYASL
EHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHH
SFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSIWQ
HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDVGIYGLGVMGGNLALNIADNGFNVSVYNRDSEKTEIFVKQNSHKKINGFKDVESFVKS
CCCCEEEEEEECCCEEEEEECCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHH
LKPPRKIILMVTSLAVEKVVEQILPLLNKSDIIIDGGNSHYKNTMRIEKELFAKDIYFVG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEE
LGISGGERGARFGPALMYGGSKSAYEILEPILNKIAAKTKNNDVCSTYIGENGSGHYVKM
EECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCEEEE
IHNGVEYADMQLISEVYFFMKKAFNLDNSKISEVFEKWNEGDLSGYLLEITSKILRYKEN
ECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
NEYLVDKILDVANQKGTGVWTSIDALESSMPVNLILESVFSRFMSGLKHERIIASDLLKM
CCHHHHHHHHHHCCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DTASFEFELSDWILDLYYALLVSKIVAYAQGFMMLKTASVNYSWDLNLGKISLVWREGCI
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCEEEEEEECCCE
IRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLRRIVSKASEIGIPLPAFYASL
EHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHH
SFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSIWQ
HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]