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The map label for this gene is dnaX [H]

Identifier: 51598717

GI number: 51598717

Start: 484951

End: 486633

Strand: Direct

Name: dnaX [H]

Synonym: BG0474

Alternate gene names: 51598717

Gene position: 484951-486633 (Clockwise)

Preceding gene: 51598715

Following gene: 51598718

Centisome position: 53.63

GC content: 29.65

Gene sequence:

>1683_bases
ATGGCGCCTTCAAGAGGTACTGCTCTTAAGAAACGCCCCAGAGATTTCAACTCTCTTGAAGGGCAAGATTTTGTTGTTGA
AACTCTAAAGCATTCTATAGAGAAAAATAAAATAGCGAATGCTTATATTTTTTCGGGACCAAGAGGTGTTGGGAAGACTT
CATCAGCCAGAGCTTTTGCTAGATGCTTAAATTGCAAGAATGGTCCGACAGTTATGCCTTGTGGAGAGTGTAATAATTGT
AAATCTATTGAGAATGATAGCAGTCTTGATGTTATTGAAATTGATGGTGCTTCAAATACTTCGGTTCAGGATATTAGGCA
AATTAAAGAAGAAATAATGTTTCCTCCTGCAATTTCTAAATATCGAATATATATTATTGATGAAGTGCATATGCTTTCCA
ATTCTGCTTTTAATGCTCTTTTAAAGACAATTGAAGAGCCCCCCAATTATATTGTTTTTATTTTTGCTACTACAGAGTCA
CATAAACTTCCAGAGACAATAAAAAGCAGATGTCAGCATTTTAGTTTTAAACTTTTGTCTTTAGAAAAAATTTATAATAT
GCTTAAGAAAGTTTGCTTTGAAGATCATATTAAATATGAAGATGAGGCTTTAAAATGGATTGCATATAAAAGTAGTGGTA
GTGTAAGAGATGCTTACACTCTTTTTGATCAGGTAGTTTCTTTTACTAGTTCTGACATTAAATTAGATCAAATAAGATCT
AAGATGGGCTTAACCAATGATGAATTTTTAGAGAAGTTGTCAGCTAGTATTCTTAGCGAGGATGTAAAAGAGTTAATTTG
TGTTCTTGATTCTATTTTTTTGTCCGGGGTGTCTTATGAGCAATTCCTACTAGATTCAATCGAATTTTTTAGAGAGGCAT
TATTTTTAAAGATAGGCATTAAAAATTTTGAGTTTATTGGAATTAAATCTGAAGATTTAAGAAAAAAATTAGCTGAGTTT
GATTTGAACTATCTTGAGAGGATTATTGTTGTTTTGCTTGAAACTTACAGAGATTTGCAATTTTCGGTTAATCCAAGATA
TGAGCTTGAGATTAATTTTGTTAAAATTTTAAGACTTAAAAACTATATTCCAAATCATGTTTTAATAAAACAAATTCAAA
ATCTTGAAGACAATTTGTTAGAAAATATGGCTTTAGATTCAAGCAATTTTGATGTTTTAGCAAATAAGAAGAATAAAGAT
GATTTAGCTTTTATTTCAGCAAAACCTGGTTTAGAAGATGAATTTCCTGAAATCAGACCTTTAGAAAAAGAGGAGACTAG
TTTTGATAAAAATTTGTCAACAAAAATTGATGAAAATCTTTTAGAGGCCAATAGCATTGAGGAGATTGATGAGATTTTTA
TTGAGGATGATAATTCAAGTGAAGCAAATGATTTTATTAATATAAGAGATAAATTTATTTATGTTGTTTCAAGGTATATT
CAAACTTTAGTTCATTCAGGAGAAGTTGTTATTGATGACAATGTTCTCTATTATAAGGTGTTTAGTGAATTTGAGTATAA
TGAGCTTCAAAATTATAAAGGTGAAATAAGGTCTGAGTTTTATAAAGAATTTCCCAATTTAAGCATTGTTTTTCAGAAAA
ATTTTAAAAGCCTTGAAAAGGATTTTGAAAAATTAGAAACTGTAAAAAATATTTTTGGAGCAAGTGAAGTTCTGGAGGGA
TAG

Upstream 100 bases:

>100_bases
TTGGTAAATCTTTTAAAATAATAGTTCTGAGATATAAATATATTGTATAGTATATATTTATAGCATTTTACTTATTAAAG
CATTGGGAGGTAAAACGTTA

Downstream 100 bases:

>100_bases
AAATATGGCAGTAAATCCATTAGATTTTTTAAAAAATATGTCTAGCGTTAAGAACAATATTGACAATATTAAAAAGGAAA
TGTCTAAAATTACGGTTTGT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MAPSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCKNGPTVMPCGECNNC
KSIENDSSLDVIEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTES
HKLPETIKSRCQHFSFKLLSLEKIYNMLKKVCFEDHIKYEDEALKWIAYKSSGSVRDAYTLFDQVVSFTSSDIKLDQIRS
KMGLTNDEFLEKLSASILSEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLAEF
DLNYLERIIVVLLETYRDLQFSVNPRYELEINFVKILRLKNYIPNHVLIKQIQNLEDNLLENMALDSSNFDVLANKKNKD
DLAFISAKPGLEDEFPEIRPLEKEETSFDKNLSTKIDENLLEANSIEEIDEIFIEDDNSSEANDFINIRDKFIYVVSRYI
QTLVHSGEVVIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKSLEKDFEKLETVKNIFGASEVLEG

Sequences:

>Translated_560_residues
MAPSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCKNGPTVMPCGECNNC
KSIENDSSLDVIEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTES
HKLPETIKSRCQHFSFKLLSLEKIYNMLKKVCFEDHIKYEDEALKWIAYKSSGSVRDAYTLFDQVVSFTSSDIKLDQIRS
KMGLTNDEFLEKLSASILSEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLAEF
DLNYLERIIVVLLETYRDLQFSVNPRYELEINFVKILRLKNYIPNHVLIKQIQNLEDNLLENMALDSSNFDVLANKKNKD
DLAFISAKPGLEDEFPEIRPLEKEETSFDKNLSTKIDENLLEANSIEEIDEIFIEDDNSSEANDFINIRDKFIYVVSRYI
QTLVHSGEVVIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKSLEKDFEKLETVKNIFGASEVLEG
>Mature_559_residues
APSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCKNGPTVMPCGECNNCK
SIENDSSLDVIEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESH
KLPETIKSRCQHFSFKLLSLEKIYNMLKKVCFEDHIKYEDEALKWIAYKSSGSVRDAYTLFDQVVSFTSSDIKLDQIRSK
MGLTNDEFLEKLSASILSEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLAEFD
LNYLERIIVVLLETYRDLQFSVNPRYELEINFVKILRLKNYIPNHVLIKQIQNLEDNLLENMALDSSNFDVLANKKNKDD
LAFISAKPGLEDEFPEIRPLEKEETSFDKNLSTKIDENLLEANSIEEIDEIFIEDDNSSEANDFINIRDKFIYVVSRYIQ
TLVHSGEVVIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKSLEKDFEKLETVKNIFGASEVLEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=231, Percent_Identity=26.4069264069264, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31881687, Length=231, Percent_Identity=26.4069264069264, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31563534, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=361, Percent_Identity=32.6869806094183, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17554730, Length=287, Percent_Identity=25.7839721254355, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=209, Percent_Identity=27.7511961722488, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=223, Percent_Identity=25.5605381165919, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=275, Percent_Identity=24, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859927, Length=221, Percent_Identity=26.6968325791855, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647857, Length=321, Percent_Identity=22.1183800623053, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64615; Mature: 64484

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFA
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
RCLNCKNGPTVMPCGECNNCKSIENDSSLDVIEIDGASNTSVQDIRQIKEEIMFPPAISK
HHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESHKLPETIKSRCQHFSFKLLS
EEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LEKIYNMLKKVCFEDHIKYEDEALKWIAYKSSGSVRDAYTLFDQVVSFTSSDIKLDQIRS
HHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
KMGLTNDEFLEKLSASILSEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
KNFEFIGIKSEDLRKKLAEFDLNYLERIIVVLLETYRDLQFSVNPRYELEINFVKILRLK
CCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHHHHHHH
NYIPNHVLIKQIQNLEDNLLENMALDSSNFDVLANKKNKDDLAFISAKPGLEDEFPEIRP
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCC
LEKEETSFDKNLSTKIDENLLEANSIEEIDEIFIEDDNSSEANDFINIRDKFIYVVSRYI
CCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
QTLVHSGEVVIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKSLEK
HHHHHCCCEEEECCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHH
DFEKLETVKNIFGASEVLEG
HHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure 
APSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFA
CCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
RCLNCKNGPTVMPCGECNNCKSIENDSSLDVIEIDGASNTSVQDIRQIKEEIMFPPAISK
HHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESHKLPETIKSRCQHFSFKLLS
EEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LEKIYNMLKKVCFEDHIKYEDEALKWIAYKSSGSVRDAYTLFDQVVSFTSSDIKLDQIRS
HHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
KMGLTNDEFLEKLSASILSEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
KNFEFIGIKSEDLRKKLAEFDLNYLERIIVVLLETYRDLQFSVNPRYELEINFVKILRLK
CCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHHHHHHH
NYIPNHVLIKQIQNLEDNLLENMALDSSNFDVLANKKNKDDLAFISAKPGLEDEFPEIRP
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCC
LEKEETSFDKNLSTKIDENLLEANSIEEIDEIFIEDDNSSEANDFINIRDKFIYVVSRYI
CCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
QTLVHSGEVVIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKSLEK
HHHHHCCCEEEECCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHH
DFEKLETVKNIFGASEVLEG
HHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]