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The map label for this gene is mutL

Identifier: 51594775

GI number: 51594775

Start: 506287

End: 508194

Strand: Direct

Name: mutL

Synonym: YPTB0423

Alternate gene names: 51594775

Gene position: 506287-508194 (Clockwise)

Preceding gene: 51594774

Following gene: 51594776

Centisome position: 10.67

GC content: 50.47

Gene sequence:

>1908_bases
ATGCCGATTCAGATTCTGCCTCCACAGCTTGCCAACCAGATTGCCGCCGGTGAGGTGGTAGAGCGGCCTGCATCGGTAGT
CAAAGAGTTGGTAGAAAACAGTCTGGATGCGGGTGCTACACGGATTGATATTGATATTGAACGTGGTGGGGCGAAACTTA
TTCGCATCCGTGATAATGGCTGCGGCATCAGTAAAGATGATTTGGCACTGGCGTTGGCCCGCCACGCCACCAGCAAAATC
AGTTCACTCGAGGATTTAGAAGCCATCCTCAGTATGGGGTTTCGCGGTGAAGCCTTGGCCAGTATCAGTTCAGTTTCACG
TCTTATCTTAACCTCACGTACCGCTGAGCAAAGCGAAGCCTGGCAAGCCTATGCCGAAGGTCGCGACATGGCGGTCACCA
TCAAGCCTGCGGCACACCCGGTTGGCAGTACACTTGAAGTGTTGGATTTATTTTATAACACCCCCGCGCGCCGCAAATTT
ATGCGAACTGAAAAGACGGAGTTTGGTCATATTGATGAGGTCGTCAGGCGCATTGCGCTGGCGCGCTTCGATGTGGCAAT
AAATTTGAACCACAATGGTAAGTTAATTCGCCAATATCGTGCGGCACCAGACCCTGCCCAACATGAGCGTCGGTTGGCAA
GTATTTGTGGTCCGGCGTTTTTGCAACATGCTTTGGCTATCGCTTGGCAGCACGGGGATTTGAACATTCATGGTTGGGTG
GCGGATCCTGCCGCGAGCCATACGCTGAGTGAAATGCAATATTGCTATGTCAATAACCGCATGATGCGTGATCGGTTGAT
TAATCACGCGATTCGCCAGGCTTATCAAGATCGACTCAACGATGCTCAACAGCCCGCTTATGTTTTGTATCTGGATATCG
ATCCGCATCAGGTTGATGTCAACGTTCATCCGGCTAAGCATGAAGTGCGTTTTCATCAGGCTCGGTTGGTACATGACTTT
ATTTATCAGGCAGTCACTGCGGTTTTACAACAAACTAATGCGCCGATACTGAACATCAGTGAAGAAGGTGAAGTTGACGC
TCCACGTTGGCAGCAGGAAAACCGGGTAGCGGCTGGCACCAATAAATATGCTCAACCGGAAGCGGCGAAATCCAGTGCGG
CGGAGCAGGCTGTGGCTCGCGAGCGTTCGTCTGCCCGTGAACGCGCTGCGCCGGCCTATAAAGAAGATCACCCCTATCAG
AAGCAACAAGGGGAGTTATACCGCCAGCTATTGCAACCGTCAGCGGCAGCCAAACCCGCAACATCGCCAGCGGCAATACC
TGCGTCATCTGTTTCCTCACCATCCATCCCGGTTCAACGAATTACTCAGGCAGAAGAGCCGCTTCACGGTGATAATTACA
GTTTTGGCCGAGTTTTAACGGTTTTTCCACCTTGTTATGCTTTGATTGAATATCAGGGCGGGGTAGCATTGCTATCCTTA
GCCGTTGCGGAGCGCTGGTTGAAACAAGCTCAGCTCAGCCCGCCAGAAGAGGGGTTACGCCCTCAACCGTTATTGATTCC
ACTCAAAATCACATTAGACAAAAATGAAATAGCGGCTTGTCAGAACCATGAAAAATTGCTAATTACCATGGGAATAGAGC
TGAGTGTCGAGCAGGGGCGGGCGACCTTACGTGCGGTTTCTTTACCATTACGCCAACAAAATTTACAAAAACTGATACCG
GAACTGTTAGGCTATCTGTCGCAGCATGAAGAGATATCGCCAGATACACTGGCCACATGGCTTGCCCGCCATCTTGGTAG
CGAACATGAGGTATGGAATGTGTCTCAAGCGATACAGTTATTGACGGAAGTTGAGCGTCTTTGTCCGCAGTTGGTGCAAT
CTCCTCCTGCTGGGCTATTACAACCTATTGATATAAAGGCCGCATTGGCAACTTTGACACATGAATGA

Upstream 100 bases:

>100_bases
ATCAATGAGTGAGATTGAGCGGGTGAATAAAATCAAGTCAGGTAATGTTCAGCTTGGGCAAACGCTCACTATTCCACAAT
CGTAAGCGCAAGGAATTGTT

Downstream 100 bases:

>100_bases
TATTGAGAATCTAGATCGTCCACCGGCAATTTTTATTATGGGGCCAACTGCTTCCGGTAAAACCGCGCTCTCTATTGCGT
TGAGGCAGCGATTGCCTGTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MPIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGISKDDLALALARHATSKI
SSLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEAWQAYAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDLNIHGWV
ADPAASHTLSEMQYCYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQAVTAVLQQTNAPILNISEEGEVDAPRWQQENRVAAGTNKYAQPEAAKSSAAEQAVARERSSARERAAPAYKEDHPYQ
KQQGELYRQLLQPSAAAKPATSPAAIPASSVSSPSIPVQRITQAEEPLHGDNYSFGRVLTVFPPCYALIEYQGGVALLSL
AVAERWLKQAQLSPPEEGLRPQPLLIPLKITLDKNEIAACQNHEKLLITMGIELSVEQGRATLRAVSLPLRQQNLQKLIP
ELLGYLSQHEEISPDTLATWLARHLGSEHEVWNVSQAIQLLTEVERLCPQLVQSPPAGLLQPIDIKAALATLTHE

Sequences:

>Translated_635_residues
MPIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGISKDDLALALARHATSKI
SSLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEAWQAYAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDLNIHGWV
ADPAASHTLSEMQYCYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQAVTAVLQQTNAPILNISEEGEVDAPRWQQENRVAAGTNKYAQPEAAKSSAAEQAVARERSSARERAAPAYKEDHPYQ
KQQGELYRQLLQPSAAAKPATSPAAIPASSVSSPSIPVQRITQAEEPLHGDNYSFGRVLTVFPPCYALIEYQGGVALLSL
AVAERWLKQAQLSPPEEGLRPQPLLIPLKITLDKNEIAACQNHEKLLITMGIELSVEQGRATLRAVSLPLRQQNLQKLIP
ELLGYLSQHEEISPDTLATWLARHLGSEHEVWNVSQAIQLLTEVERLCPQLVQSPPAGLLQPIDIKAALATLTHE
>Mature_634_residues
PIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGISKDDLALALARHATSKIS
SLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEAWQAYAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKFM
RTEKTEFGHIDEVVRRIALARFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDLNIHGWVA
DPAASHTLSEMQYCYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQVDVNVHPAKHEVRFHQARLVHDFI
YQAVTAVLQQTNAPILNISEEGEVDAPRWQQENRVAAGTNKYAQPEAAKSSAAEQAVARERSSARERAAPAYKEDHPYQK
QQGELYRQLLQPSAAAKPATSPAAIPASSVSSPSIPVQRITQAEEPLHGDNYSFGRVLTVFPPCYALIEYQGGVALLSLA
VAERWLKQAQLSPPEEGLRPQPLLIPLKITLDKNEIAACQNHEKLLITMGIELSVEQGRATLRAVSLPLRQQNLQKLIPE
LLGYLSQHEEISPDTLATWLARHLGSEHEVWNVSQAIQLLTEVERLCPQLVQSPPAGLLQPIDIKAALATLTHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=336, Percent_Identity=35.7142857142857, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4505911, Length=317, Percent_Identity=31.8611987381703, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI189458898, Length=317, Percent_Identity=31.8611987381703, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI189458896, Length=315, Percent_Identity=29.5238095238095, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI4505913, Length=359, Percent_Identity=26.4623955431755, Blast_Score=131, Evalue=3e-30,
Organism=Homo sapiens, GI310128478, Length=359, Percent_Identity=26.4623955431755, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=30.3643724696356, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI91992162, Length=356, Percent_Identity=23.876404494382, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI91992160, Length=356, Percent_Identity=23.876404494382, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI310128480, Length=317, Percent_Identity=23.3438485804416, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790612, Length=639, Percent_Identity=65.1017214397496, Blast_Score=801, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=37.3831775700935, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=26.7441860465116, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=36.9085173501577, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=343, Percent_Identity=25.9475218658892, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=26.8965517241379, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=361, Percent_Identity=24.6537396121884, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136968, Length=383, Percent_Identity=33.420365535248, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=26.2569832402235, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70289; Mature: 70158

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGISKDDLALALARHATSKISSLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAYAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDLNIHGWV
HHEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEE
ADPAASHTLSEMQYCYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQVDV
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAVTAVLQQTNAPILNISEEGEVDAPRWQQENRVAAGT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCEECCC
NKYAQPEAAKSSAAEQAVARERSSARERAAPAYKEDHPYQKQQGELYRQLLQPSAAAKPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
TSPAAIPASSVSSPSIPVQRITQAEEPLHGDNYSFGRVLTVFPPCYALIEYQGGVALLSL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCEEHHCCCCCHHHHHH
AVAERWLKQAQLSPPEEGLRPQPLLIPLKITLDKNEIAACQNHEKLLITMGIELSVEQGR
HHHHHHHHHHCCCCCHHCCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEECCEEEEHHCH
ATLRAVSLPLRQQNLQKLIPELLGYLSQHEEISPDTLATWLARHLGSEHEVWNVSQAIQL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
LTEVERLCPQLVQSPPAGLLQPIDIKAALATLTHE
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
PIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGISKDDLALALARHATSKISSLEDLEAILSMGFRGEALASISSVSRLILTSRTAEQSEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAYAEGRDMAVTIKPAAHPVGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVAINLNHNGKLIRQYRAAPDPAQHERRLASICGPAFLQHALAIAWQHGDLNIHGWV
HHEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEE
ADPAASHTLSEMQYCYVNNRMMRDRLINHAIRQAYQDRLNDAQQPAYVLYLDIDPHQVDV
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAVTAVLQQTNAPILNISEEGEVDAPRWQQENRVAAGT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCEECCC
NKYAQPEAAKSSAAEQAVARERSSARERAAPAYKEDHPYQKQQGELYRQLLQPSAAAKPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
TSPAAIPASSVSSPSIPVQRITQAEEPLHGDNYSFGRVLTVFPPCYALIEYQGGVALLSL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCEEHHCCCCCHHHHHH
AVAERWLKQAQLSPPEEGLRPQPLLIPLKITLDKNEIAACQNHEKLLITMGIELSVEQGR
HHHHHHHHHHCCCCCHHCCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEECCEEEEHHCH
ATLRAVSLPLRQQNLQKLIPELLGYLSQHEEISPDTLATWLARHLGSEHEVWNVSQAIQL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
LTEVERLCPQLVQSPPAGLLQPIDIKAALATLTHE
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA