Definition Propionibacterium acnes KPA171202, complete genome.
Accession NC_006085
Length 2,560,265

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The map label for this gene is cbiH [H]

Identifier: 50841905

GI number: 50841905

Start: 465566

End: 468136

Strand: Direct

Name: cbiH [H]

Synonym: PPA0422

Alternate gene names: 50841905

Gene position: 465566-468136 (Clockwise)

Preceding gene: 50841904

Following gene: 50841906

Centisome position: 18.18

GC content: 62.7

Gene sequence:

>2571_bases
ATGATTCGCGTCCACGGATATCTCGGCACTATTAGCGACGCCCTGCGCGAGGAAGTTACCCAGGCTGATCTCGTCGTCGG
TGGTCAGCGTCACCTTGATGCCCTCGCTGTCCCCGACGATAAGCGTCAGAAACTTGGACTTATCGGGCCTGCCATTGAGC
GGATCCAGTCGCTGCCTGACGACGCCAACGTCGTTGTTATCGCCTCCGGTGACCCGCTGTTTTTCGGTGTGGTTCGCCGG
ATCCGACAGGCCGGTTTGCGTGTCGAGGTGGTGACGGCTCCGACCTCTTTGCAGGCAGCGTTCGCCGCGGTCGCCCTGCC
GTGGGATGACGCCCAGTTTGTCTCCTCCCACTCCAAGGACATCGAAACGGCCGTTCGGCTTGCGAAGATCCATCCCAAGG
TTGGCGTGCTGACGGCGCCCAATCGAGGTCTCGCTGAGCTGGTTGATGGGCTTGCAGGTCGCGGCAAGACCTTCGTGCTG
GCCGAGAAGATCGGTGAAGAGGGTCAGCGAGTACGCGTTCTGGACGAGGACGCTGCCAAAGCCGTTATCGCCGATGAGGA
CATCCTTAGCCCCAACGTCGTGCTGGTGCTTGAGCACCACCCGGATTCTCCGGAGGCCCTCGGTATCAACCCCGAGCTCG
CTGGTGATGTCAACGTCAACGGTCCCGACGACCCGCAGCCAGGTTCCGACACCAACCCCGACGGTTCCGACCGTGATCCG
ATCATCGGACAGATCATCAACTCCGACGCTGCCGTAGCCCACGCCGAGGCCATTGACCGCGCTCTCAAGCGTGAGACGAA
GAAGTATGTCGGGCCATCGCGCACCGGTCTGGCCGCCGCATGGGGGGAGTGCGATCTCATCGTTTCCCACTTGGCCCTGG
GCGCTACTACGCGGATCATTGCCCCACTACTGGAGTCCAAGAAGACTGACCCGGGAGTGGTCGTCGTTGACGAGGCTGGA
CGCTTCGCCATCCCGTTGGTGGGTGGTCACGTCGGTGGAGCCAACGAACTCTCCCGCACCGTTGCCGAGGCCCTCAGCGG
CACCGCCGTTGTCTCCACCGCTACCGACTCCCTCGGTGTACCGGCCCTCGACCAGCTTGGCTGGGCCTACGAGGGTGATG
TCGCGGGTGTAACCGGATCGATCATCGCCGGACGTCCGGTGCTCGTCGTCCGCGAGCAGCCTTGGCCGTTGCCCCCGCTA
CCCCAGAACGTCACCGAGGACGTCGAGACCCCGGCTGCCCGGGTTATCGTTTCCGAGCGGGTTGCAGAGCGCGTCTTCGT
CGATCACGGTGACGACCTGCCTACCGTTGTCTTGCATCCGAGCTGTCTAGTCGTTGGGATGGGATGCAACAAGGGCACCG
AGGTCGAGTCGCTGCGTCAACTCCTCGTTAAGACTTTGGAGGATAACGGCCTGGCTCTCGGTTCGGTGACCCGCTTGGTG
TCCCACGAGGTTAAGGCCGGCGAGCTTGGTTTGGTGAAGCTGGCTAACCAACTCGGTGTGGAATATCGCACTGAGTCCGC
CGAGGCTCTGGCCGCCCACGATGTCCCGACACCTTCCGACGTCGTTGCCCGGGAGGTCGGGACGCCGAGCGTCAGTGAGG
CCGCGGTGTTGTGCCAGGGGGCCGAGTTGCTGGTACATAAGACCAAAACCTCGGAGGCTACCTGCGCCATCGGCCGCATC
CCGGCACGTGGCCATCTGTCGGTGGTTGGGCTCGGACCGGGCTCCCGTGATCTGCTGACTCCGCGCGCCGTCGAGGCCAT
CCGCAATGCGACTTTCGTTGCCGGCTACGCCCCCTACGTGCGTCAGATACGAGACCTGGTGCGCCCAGGGGCCACAATCC
TGGCCACCAAGATGGGCACCGAAGAAGAGCGCACTCAGGCCGCTATCGAGGCCACCCGGGACGGCCGCAATGTAGCTTTC
GTGTGTGGTGGCGACCCGGCCATCTACGCGATGGCCTCCCCTACTCTGGAGATGGGTACCGACGGTATCGACGTCGAGAT
CGTCCCTGGAGTCACCGCTGAGCTCGCCATCTCGGCGATCCTCGGTGCTCCGTTGGGACATGATCACGCCACTATCTCCC
TGTCGGACCTGCATACCGACTGGGACCTCATTCTCAAGCGCGTAAAGGCGGCTGCTGAGGGAGACCTCGTCACCACCTTC
TATAACCCGCGTTCGCGCACTCGTACCCACCAGCTCCCTGATGCCCTGGCGATCATGGCCGAGCACCGTCCGCCTTCCAC
CCCGGTGGCCCTGGTCTCCCACGCTGAGCGCCGTCAACAGCAAGTGATCATGTCTACCCTCGAAGAGTTCAAGCCCGAGT
GGTGTGGCATGACAACCTTGGTTGTCGTCGGCTCGACGACGACCAAGTACGTCAGCTCCGGTGATGGACGACGTCTCATG
GTCACCCCGCGTGACTACCACTGGATGGACGGGCACGTGTGTAGCGAGGCTCGCAAGAATTACACCCACAAGGACTTGCC
CAAGGCCGACGAAGAGACTTATCTCTCCAAGCCTCCGGTTCACTCCACTCGCATGTCTGAGCCCATAAACGACACAAAGG
ATTCGAAATGA

Upstream 100 bases:

>100_bases
ATCGCGCAGCCGACGCTCAGGCCCACGCTGACCTCAAGGCTCACGGTACCTGCGGCGTCTACCACCGGAACTCCACGAAC
CCCGACACGAAGGGCAATTC

Downstream 100 bases:

>100_bases
CCGATCCCCTCACCAGCGGAACTCCGCTGGTCATCGCTGCCCACGGCACCCGCGACGAGGCAGGTGTGGCCGAGTGCCGT
GCTTTGGCTGAGCGCGTTGC

Product: tetrapyrrole methylase, putative CbiE/G/H fusion protein

Products: 2S-adenosyl-L-homocysteine; precorrin; sirohydrochlorin; NADH; Proton; siroheme [C]

Alternate protein names: Cobalt-precorrin-3 methylase; Cobalt-precorrin-3 methyltransferase [H]

Number of amino acids: Translated: 856; Mature: 856

Protein sequence:

>856_residues
MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPDDKRQKLGLIGPAIERIQSLPDDANVVVIASGDPLFFGVVRR
IRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKDIETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVL
AEKIGEEGQRVRVLDEDAAKAVIADEDILSPNVVLVLEHHPDSPEALGINPELAGDVNVNGPDDPQPGSDTNPDGSDRDP
IIGQIINSDAAVAHAEAIDRALKRETKKYVGPSRTGLAAAWGECDLIVSHLALGATTRIIAPLLESKKTDPGVVVVDEAG
RFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGVPALDQLGWAYEGDVAGVTGSIIAGRPVLVVREQPWPLPPL
PQNVTEDVETPAARVIVSERVAERVFVDHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLV
SHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQGAELLVHKTKTSEATCAIGRI
PARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYVRQIRDLVRPGATILATKMGTEEERTQAAIEATRDGRNVAF
VCGGDPAIYAMASPTLEMGTDGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTF
YNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTLVVVGSTTTKYVSSGDGRRLM
VTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPVHSTRMSEPINDTKDSK

Sequences:

>Translated_856_residues
MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPDDKRQKLGLIGPAIERIQSLPDDANVVVIASGDPLFFGVVRR
IRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKDIETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVL
AEKIGEEGQRVRVLDEDAAKAVIADEDILSPNVVLVLEHHPDSPEALGINPELAGDVNVNGPDDPQPGSDTNPDGSDRDP
IIGQIINSDAAVAHAEAIDRALKRETKKYVGPSRTGLAAAWGECDLIVSHLALGATTRIIAPLLESKKTDPGVVVVDEAG
RFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGVPALDQLGWAYEGDVAGVTGSIIAGRPVLVVREQPWPLPPL
PQNVTEDVETPAARVIVSERVAERVFVDHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLV
SHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQGAELLVHKTKTSEATCAIGRI
PARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYVRQIRDLVRPGATILATKMGTEEERTQAAIEATRDGRNVAF
VCGGDPAIYAMASPTLEMGTDGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTF
YNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTLVVVGSTTTKYVSSGDGRRLM
VTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPVHSTRMSEPINDTKDSK
>Mature_856_residues
MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPDDKRQKLGLIGPAIERIQSLPDDANVVVIASGDPLFFGVVRR
IRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKDIETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVL
AEKIGEEGQRVRVLDEDAAKAVIADEDILSPNVVLVLEHHPDSPEALGINPELAGDVNVNGPDDPQPGSDTNPDGSDRDP
IIGQIINSDAAVAHAEAIDRALKRETKKYVGPSRTGLAAAWGECDLIVSHLALGATTRIIAPLLESKKTDPGVVVVDEAG
RFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGVPALDQLGWAYEGDVAGVTGSIIAGRPVLVVREQPWPLPPL
PQNVTEDVETPAARVIVSERVAERVFVDHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLV
SHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQGAELLVHKTKTSEATCAIGRI
PARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYVRQIRDLVRPGATILATKMGTEEERTQAAIEATRDGRNVAF
VCGGDPAIYAMASPTLEMGTDGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTF
YNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTLVVVGSTTTKYVSSGDGRRLM
VTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPVHSTRMSEPINDTKDSK

Specific function: Methyltransferase that catalyzes the methylation of C-17 in cobalt-precorrin-3B to form cobalt-precorrin-4 [H]

COG id: COG1010

COG function: function code H; Precorrin-3B methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=224, Percent_Identity=31.25, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006363 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: 2.1.1.107; 1.3.1.76; 4.99.1.4 [C]

Molecular weight: Translated: 90970; Mature: 90970

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPDDKRQKLGLIGPAIERIQSLPD
CEEEEEEHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCHHHHCCCCCHHHHHHHHCCC
DANVVVIASGDPLFFGVVRRIRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKD
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHEEECCCCCHHHHHHCCHH
IETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVLAEKIGEEGQRVRVLDEDAAK
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEHHHCCCCCEEEEECCCCCC
AVIADEDILSPNVVLVLEHHPDSPEALGINPELAGDVNVNGPDDPQPGSDTNPDGSDRDP
EEECCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
IIGQIINSDAAVAHAEAIDRALKRETKKYVGPSRTGLAAAWGECDLIVSHLALGATTRII
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
APLLESKKTDPGVVVVDEAGRFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGV
HHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
PALDQLGWAYEGDVAGVTGSIIAGRPVLVVREQPWPLPPLPQNVTEDVETPAARVIVSER
CCHHHCCCEECCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHH
VAERVFVDHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLV
HHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
SHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQG
HHCCCCCCCHHHHHHHHHCCEEECCCCHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCC
AELLVHKTKTSEATCAIGRIPARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYV
CEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEEECCHHHH
RQIRDLVRPGATILATKMGTEEERTQAAIEATRDGRNVAFVCGGDPAIYAMASPTLEMGT
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCHHCCC
DGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTF
CCCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCCEEEEE
YNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTL
ECCCCCCHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEE
VVVGSTTTKYVSSGDGRRLMVTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPV
EEECCCHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
HSTRMSEPINDTKDSK
CCHHCCCCCCCCCCCC
>Mature Secondary Structure
MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPDDKRQKLGLIGPAIERIQSLPD
CEEEEEEHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCHHHHCCCCCHHHHHHHHCCC
DANVVVIASGDPLFFGVVRRIRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKD
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHEEECCCCCHHHHHHCCHH
IETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVLAEKIGEEGQRVRVLDEDAAK
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEHHHCCCCCEEEEECCCCCC
AVIADEDILSPNVVLVLEHHPDSPEALGINPELAGDVNVNGPDDPQPGSDTNPDGSDRDP
EEECCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
IIGQIINSDAAVAHAEAIDRALKRETKKYVGPSRTGLAAAWGECDLIVSHLALGATTRII
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
APLLESKKTDPGVVVVDEAGRFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGV
HHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
PALDQLGWAYEGDVAGVTGSIIAGRPVLVVREQPWPLPPLPQNVTEDVETPAARVIVSER
CCHHHCCCEECCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHH
VAERVFVDHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLV
HHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
SHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQG
HHCCCCCCCHHHHHHHHHCCEEECCCCHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCC
AELLVHKTKTSEATCAIGRIPARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYV
CEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEEECCHHHH
RQIRDLVRPGATILATKMGTEEERTQAAIEATRDGRNVAFVCGGDPAIYAMASPTLEMGT
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCHHCCC
DGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTF
CCCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCCEEEEE
YNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTL
ECCCCCCHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEE
VVVGSTTTKYVSSGDGRRLMVTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPV
EEECCCHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
HSTRMSEPINDTKDSK
CCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2S-Adenosyl-L-methionine; uroporphyrin III; dihydrosirohydrochlorin; NAD; sirohydrochlorin; Fe (II) [C]

Specific reaction: 2S-Adenosyl-L-methionine + uroporphyrin III = 2S-adenosyl-L-homocysteine + precorrin dihydrosirohydrochlorin + NAD = sirohydrochlorin + NADH sirohydrochlorin + Fe (II) = 2 Proton + siroheme [C]

General reaction: Methyl group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609 [H]