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The map label for this gene is hemL

Identifier: 50841789

GI number: 50841789

Start: 351044

End: 352354

Strand: Reverse

Name: hemL

Synonym: PPA0301

Alternate gene names: 50841789

Gene position: 352354-351044 (Counterclockwise)

Preceding gene: 50841790

Following gene: 50841788

Centisome position: 13.76

GC content: 64.91

Gene sequence:

>1311_bases
ATGACCTCCAACGCCGAACTGTTCTCCGCCGCCCAGGCCGTCATTCCCGGCGGGGTTGATTCCCCGGTGCGGGCTTACGG
CTCGGTGGGCGGGGTTCCTCGCTTCATTGAGAAGGCCCAAGGCCCGTGGATCTGGGACGCCGAGGGCACGCGCTACGTCG
ATCTGGTGTGCACCTGGGGTCCGGCTTTGCTTGGGCACGCCCGTCCCGAGGTCGTCTCTGCGGTTCAGGTGGCCGCGTCG
AAAGGGCTGTCCTTTGGCGCCCCGACCCGCACCGAAACCGAACTAGCGGATGCCATCATCGAGCGGATGGCTCCGGTCGA
GAAGGTGCGTTTCGTCTCAACAGGCACTGAGGCGACAATGACTGCGGTCCGTTTAGCCCGTGGCGCCACTGGGCGTGACG
TCATCGTCAAGTTTGCCGGTAATTACCACGGCCATTCTGACGTCCTGCTCGCCGCCGCCGGTTCCGGCGTGGCGACGGCT
GGCCTGCCCGGTTCGGCCGGTGTGCCAGCCGCCTCGACGGCCGACACTATTGTGGTGGATTACAACGACGTCGCCGCCCT
CGACGCGGTGTTCTCCGAGCGTGGCGACCAGATTGCTGCAGTGATCGTGGAGTCCTGCCCGGCCAATATGGGAGTTGTTC
CCCCCGAACCCGGCTTCAATGCCGCGATTCGTCGCCTCACAACCGAGCACGGCGCCCTCATGATCACCGACGAAGTACTC
ACCGGATTCCGGTGCAGCCCGTCGGGATTCTGGGGTTTGCAACAGCAGGCCGGCGAGGACTTCGCGCCCGACATTTTCAC
CTTCGGCAAGGTCGTGGGCGGAGGCATGCCGCTGGCTGCCCTGGGTGGGCACGCCGATGTCATGGACTTGCTGGCTCCTA
CCGGCCCCGTCTACCAGGCCGGCACTTTGTCCGGTAACCCGCTGGCCACCGTCGCGGGTGTCAAAACCCTACAGCTGGCC
GACGCCGAGGTGTATCAGCGCCTCGATGTCCGCTCCGAGAAATGGCGCAATGAGCTCGAATCCGCACTTGACGCAGCCGG
CGTCACGTACCGCCTGCAGAACGCCGGAAATCTCTTCAGCGTATTCCTCGGCGTCGACTCCCCGGTGCGCAATTACGACA
ACGCCAAGTCTCAGAATGCCGAGGCTTACACCGCGTTCTTCCACGCGATGCTAGATGCCGGGGTCAACCTGCCGCCATCG
TGCTTTGAGGCCTGGTTCCTCTCGGACGCTCACGACGACGAAGCTTTCGAGGTTTTCCGCGCCGCCCTGCCGAGGGCTGC
CCAGGCGGCTGCCCAGGTGATCAGTGCCTGA

Upstream 100 bases:

>100_bases
TCTTGACCTACTGGGCAATCGAGGCGGCGCAGATGTTTCGCGAGGACCTCTGACCCGTCGTGATCATGCTCACCACAAAC
CCCCACACCGGAAGGAAGAA

Downstream 100 bases:

>100_bases
CACCGGGCTGACTTCGCACGTCATCGAGGCAATCTGTGCCTGGTTCGACGCCAACGGACGCGATCTGCCGTGGCGCCGAC
CCGGCACCTCCGCGTGGGGC

Product: glutamate-1-semialdehyde 2,1-aminomutase, HemL

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWGPALLGHARPEVVSAVQVAAS
KGLSFGAPTRTETELADAIIERMAPVEKVRFVSTGTEATMTAVRLARGATGRDVIVKFAGNYHGHSDVLLAAAGSGVATA
GLPGSAGVPAASTADTIVVDYNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVL
TGFRCSPSGFWGLQQQAGEDFAPDIFTFGKVVGGGMPLAALGGHADVMDLLAPTGPVYQAGTLSGNPLATVAGVKTLQLA
DAEVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFSVFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPS
CFEAWFLSDAHDDEAFEVFRAALPRAAQAAAQVISA

Sequences:

>Translated_436_residues
MTSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWGPALLGHARPEVVSAVQVAAS
KGLSFGAPTRTETELADAIIERMAPVEKVRFVSTGTEATMTAVRLARGATGRDVIVKFAGNYHGHSDVLLAAAGSGVATA
GLPGSAGVPAASTADTIVVDYNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVL
TGFRCSPSGFWGLQQQAGEDFAPDIFTFGKVVGGGMPLAALGGHADVMDLLAPTGPVYQAGTLSGNPLATVAGVKTLQLA
DAEVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFSVFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPS
CFEAWFLSDAHDDEAFEVFRAALPRAAQAAAQVISA
>Mature_435_residues
TSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWGPALLGHARPEVVSAVQVAASK
GLSFGAPTRTETELADAIIERMAPVEKVRFVSTGTEATMTAVRLARGATGRDVIVKFAGNYHGHSDVLLAAAGSGVATAG
LPGSAGVPAASTADTIVVDYNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVLT
GFRCSPSGFWGLQQQAGEDFAPDIFTFGKVVGGGMPLAALGGHADVMDLLAPTGPVYQAGTLSGNPLATVAGVKTLQLAD
AEVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFSVFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPSC
FEAWFLSDAHDDEAFEVFRAALPRAAQAAAQVISA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI24119277, Length=313, Percent_Identity=29.3929712460064, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557809, Length=320, Percent_Identity=29.6875, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=27.1634615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=26.1390887290168, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=26.7532467532467, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI284507298, Length=238, Percent_Identity=31.5126050420168, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=47.6076555023923, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1789016, Length=353, Percent_Identity=32.0113314447592, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787560, Length=343, Percent_Identity=31.1953352769679, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789759, Length=414, Percent_Identity=27.536231884058, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788044, Length=345, Percent_Identity=28.1159420289855, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI145693181, Length=319, Percent_Identity=29.4670846394984, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786991, Length=323, Percent_Identity=26.0061919504644, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=307, Percent_Identity=28.0130293159609, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=339, Percent_Identity=26.2536873156342, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=310, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=312, Percent_Identity=25.3205128205128, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356575, Length=432, Percent_Identity=25.6944444444444, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=328, Percent_Identity=27.1341463414634, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI161085790, Length=330, Percent_Identity=26.0606060606061, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574759, Length=330, Percent_Identity=26.0606060606061, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_PROAC (Q6AB08)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055016.1
- ProteinModelPortal:   Q6AB08
- SMR:   Q6AB08
- GeneID:   2932116
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0301
- NMPDR:   fig|267747.1.peg.293
- HOGENOM:   HBG725944
- OMA:   DITREND
- ProtClustDB:   CLSK2763199
- BioCyc:   PACN267747:PPA0301-MONOMER
- BRENDA:   5.4.3.8
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45502; Mature: 45370

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWG
CCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHCCCCEEECCCCCEEEEEEEECC
PALLGHARPEVVSAVQVAASKGLSFGAPTRTETELADAIIERMAPVEKVRFVSTGTEATM
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCHHHH
TAVRLARGATGRDVIVKFAGNYHGHSDVLLAAAGSGVATAGLPGSAGVPAASTADTIVVD
HHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEE
YNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVL
CCHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHH
TGFRCSPSGFWGLQQQAGEDFAPDIFTFGKVVGGGMPLAALGGHADVMDLLAPTGPVYQA
CCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCCHHHHHHHCCCCCCEEC
GTLSGNPLATVAGVKTLQLADAEVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFS
CCCCCCCCCHHHCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEE
VFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPSCFEAWFLSDAHDDEAFEVFR
EEECCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHH
AALPRAAQAAAQVISA
HHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWG
CCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHCCCCEEECCCCCEEEEEEEECC
PALLGHARPEVVSAVQVAASKGLSFGAPTRTETELADAIIERMAPVEKVRFVSTGTEATM
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCHHHH
TAVRLARGATGRDVIVKFAGNYHGHSDVLLAAAGSGVATAGLPGSAGVPAASTADTIVVD
HHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEE
YNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVL
CCHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHH
TGFRCSPSGFWGLQQQAGEDFAPDIFTFGKVVGGGMPLAALGGHADVMDLLAPTGPVYQA
CCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCCHHHHHHHCCCCCCEEC
GTLSGNPLATVAGVKTLQLADAEVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFS
CCCCCCCCCHHHCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEE
VFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPSCFEAWFLSDAHDDEAFEVFR
EEECCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHH
AALPRAAQAAAQVISA
HHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA