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The map label for this gene is ung [H]

Identifier: 50365059

GI number: 50365059

Start: 271060

End: 271710

Strand: Direct

Name: ung [H]

Synonym: Mfl243

Alternate gene names: 50365059

Gene position: 271060-271710 (Clockwise)

Preceding gene: 50365058

Following gene: 50365060

Centisome position: 34.17

GC content: 26.11

Gene sequence:

>651_bases
ATGAATAAGAAATGAAATAGTTTATTAACAAATCAAGATCTTTCAAAAAGAATTGAAAACACAATCGAGTTGGCATATAA
AACGAATGAAAAAATTTATCCCTCAAAAGAAGATTGTTTAAGATTATTTGATTTAATCTCACCAGATGAAATCAAAGTAG
TAATAATTGGTCAAGACCCGTATCATAATCCTAAACAAGCTAATGGAATAGCTTTTAGCGCAAGTAAAGATATCAAAACA
CCCAAAAGTCTAATTAATATTTTTAAAGAATTAGAAAATGACTTAGGTATAAAACATTATGATAATAATGATTTAAGCAA
TTGGGTTAAACAAGGCGTTTTATTAATTAATACTTGTTGAACTGTAATTGAAAATCAACCTGGAAGCCACTCAAAATTAG
GTTGACAAGAAATAGTTAGTGATATATTGGTTAATCTAAACAAACAGAATCCAAACATTGTTTATTGTTTATGAGGAAAT
TATGCTAAAAAGGTTTATGAAAATTTAGAACATAAAGCAAATAATGTCATTAACTCTGCTCACCCATCACCATTTAGTTA
TTTGAAAGGTTTTAAAAATTCAAAACCTTTCTCAACAATAAATACAATTTTAGTTAATAATTCTTTAGAACCAATTGATT
GGTCTAAATAA

Upstream 100 bases:

>100_bases
AAAAATGCTAAATCAGAGTTCTATTCATTTGATGAATCAGAAAGAGAAATAAGAAGATTCATAAAGGGTATTAATAATTT
TGCAAAGATAGGTGAAAACA

Downstream 100 bases:

>100_bases
GGTAAAATAATAAATAAGGAGTTACATATGAGAAAAATAAATGAATTAAACAATACAATTTCTTCAACTGATTTAGTTGT
TAGAATTGAAAAAGTTATTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNKKWNSLLTNQDLSKRIENTIELAYKTNEKIYPSKEDCLRLFDLISPDEIKVVIIGQDPYHNPKQANGIAFSASKDIKT
PKSLINIFKELENDLGIKHYDNNDLSNWVKQGVLLINTCWTVIENQPGSHSKLGWQEIVSDILVNLNKQNPNIVYCLWGN
YAKKVYENLEHKANNVINSAHPSPFSYLKGFKNSKPFSTINTILVNNSLEPIDWSK

Sequences:

>Translated_216_residues
MNKK*NSLLTNQDLSKRIENTIELAYKTNEKIYPSKEDCLRLFDLISPDEIKVVIIGQDPYHNPKQANGIAFSASKDIKT
PKSLINIFKELENDLGIKHYDNNDLSNWVKQGVLLINTC*TVIENQPGSHSKLG*QEIVSDILVNLNKQNPNIVYCL*GN
YAKKVYENLEHKANNVINSAHPSPFSYLKGFKNSKPFSTINTILVNNSLEPIDWSK
>Mature_216_residues
MNKK*NSLLTNQDLSKRIENTIELAYKTNEKIYPSKEDCLRLFDLISPDEIKVVIIGQDPYHNPKQANGIAFSASKDIKT
PKSLINIFKELENDLGIKHYDNNDLSNWVKQGVLLINTC*TVIENQPGSHSKLG*QEIVSDILVNLNKQNPNIVYCL*GN
YAKKVYENLEHKANNVINSAHPSPFSYLKGFKNSKPFSTINTILVNNSLEPIDWSK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=184, Percent_Identity=40.7608695652174, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI6224979, Length=184, Percent_Identity=40.7608695652174, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1788934, Length=196, Percent_Identity=37.7551020408163, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17556304, Length=223, Percent_Identity=37.219730941704, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323620, Length=206, Percent_Identity=38.3495145631068, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 23928; Mature: 23928

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNSLLTNQDLSKRIENTIELAYKTNEKIYPSKEDCLRLFDLISPDEIKVVIIGQDPY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
HNPKQANGIAFSASKDIKTPKSLINIFKELENDLGIKHYDNNDLSNWVKQGVLLINTCTV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCEEEEEEEEE
IENQPGSHSKLGQEIVSDILVNLNKQNPNIVYCLGNYAKKVYENLEHKANNVINSAHPSP
EECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCH
FSYLKGFKNSKPFSTINTILVNNSLEPIDWSK
HHHHHCCCCCCCHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MNKKNSLLTNQDLSKRIENTIELAYKTNEKIYPSKEDCLRLFDLISPDEIKVVIIGQDPY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
HNPKQANGIAFSASKDIKTPKSLINIFKELENDLGIKHYDNNDLSNWVKQGVLLINTCTV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCEEEEEEEEE
IENQPGSHSKLGQEIVSDILVNLNKQNPNIVYCLGNYAKKVYENLEHKANNVINSAHPSP
EECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCH
FSYLKGFKNSKPFSTINTILVNNSLEPIDWSK
HHHHHCCCCCCCHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA