Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 49188133

GI number: 49188133

Start: 5031081

End: 5032181

Strand: Reverse

Name: nuoD [H]

Synonym: BAS5147

Alternate gene names: 49188133

Gene position: 5032181-5031081 (Counterclockwise)

Preceding gene: 49188134

Following gene: 49188132

Centisome position: 96.24

GC content: 43.69

Gene sequence:

>1101_bases
ATGATCCGTACGGAAGAAATGCTTTTGAATGTAGGTCCTCAGCATCCGAGTACCCACGGTGTGTTCAGGCTTGTTATTAA
GATTGACGGGGAAATTATTAAAGAAGCTACACCAGTTATTGGATATTTGCATCGCGGAACCGAAAAGATTGCAGAGAGCT
TACAGTATACGCAAATTATCCCTTATACAGATCGGATGGACTATTTATCGGCTATGACGAATAATTACGTCATTTGCCAT
GCTGTAGAGACGATGATGGGGCTTGAAATCCCGGAGCGGGCCGAATACTTGCGAGTACTTGCAATGGAGCTTGGAAGGAT
TGCGAGCCACCTCGTTTGGTGGGGGACAAATCTTCTTGATATAGGAGCAGTTAGCCCGTTTTTGTACGCGTTCCGTGAGC
GAGAAATGATTATTAATTTATTAAACGAATTATGCGGTGCACGGCTTACTTTTAATTATATGAGAGTCGGCGGTGTGAAA
TGGGATGCACCGGATGGTTGGATTGAAAAAGTGAAAGAATTTGTTCCGTATATGAGAGAACAATTGGCAGGGTATCATGA
TCTTGTTAGCGGCAATGAGATTTTCTTAAATCGTGTAAAAGGCGTTGGTATATATAGCGCGGAGGAAGCGATTTCGTATT
CTTTAAGCGGAGCGAATTTGCGGTGTACCGGAGTAAACTGGGATCTTCGCAAGGATGAACCATATTCCATTTATGATCGT
TTTGACTTTGATATTCCTGTTGGGAGCGTGGGGGATGCCTGGGATCGCTACGTTTGCCGCATGCAGGAAATTGAGGAGTC
TTTAAAGATTGTTGAGCAAGCAGTCCAGCAGTTCCCAAAAGAAGGAGCTGTACTGGCGAAAGTACCGAAAATTATTAAGG
CGCCTAAAGGGGAAGCGTTCGTCCGTATAGAATCGCCGCGCGGAGAGATTGGTTGTTATATTGCTAGTGATGGGAAGAAA
GAGCCATACCGTTTGAAGTTTCGCAGGCCGTCTTTTTACAATTTGCAAATTTTACCGAAGTTATTGAAAGGTGAAAACAT
CGCCAATTTAATTACGATTTTAGGTGGAGTGGATATTGTACTTGGGGAGGTTGATGGCTAA

Upstream 100 bases:

>100_bases
AAGGGGCATCCAAATTTATCACGTATTTTAATGCCTGATGATTGGGTAGGGCACCCGCTTAGGAAAGATTATGAACCGTA
TGATGTGGAGGTGTAGCTAA

Downstream 100 bases:

>100_bases
TGATTGAAACGCTCTTACAATCACCTTCTAGCTGGACGAATTTCTTCATTTTTTTCGGATTAGCGGTGCTCCTATTATTT
GCAGTCCTTGGCTTCGTTAC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQIIPYTDRMDYLSAMTNNYVICH
AVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLDIGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVK
WDAPDGWIEKVKEFVPYMREQLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDR
FDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKEGAVLAKVPKIIKAPKGEAFVRIESPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIVLGEVDG

Sequences:

>Translated_366_residues
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQIIPYTDRMDYLSAMTNNYVICH
AVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLDIGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVK
WDAPDGWIEKVKEFVPYMREQLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDR
FDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKEGAVLAKVPKIIKAPKGEAFVRIESPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIVLGEVDG
>Mature_366_residues
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQIIPYTDRMDYLSAMTNNYVICH
AVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLDIGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVK
WDAPDGWIEKVKEFVPYMREQLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDR
FDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKEGAVLAKVPKIIKAPKGEAFVRIESPRGEIGCYIASDGKK
EPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIVLGEVDG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=385, Percent_Identity=39.4805194805195, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI260898743, Length=380, Percent_Identity=38.6842105263158, Blast_Score=298, Evalue=7e-81,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=38.7012987012987, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789076, Length=351, Percent_Identity=27.0655270655271, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1788832, Length=358, Percent_Identity=25.6983240223464, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=39.119170984456, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=38.3419689119171, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=40.1041666666667, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=39.2670157068063, Blast_Score=311, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 41506; Mature: 41506

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQII
CCCCHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
PYTDRMDYLSAMTNNYVICHAVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLD
CCCCHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEH
IGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVKWDAPDGWIEKVKEFVPYMRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEECCCCHHHHHHHHHHHHHHH
QLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDR
HHCCHHHHCCCCCEEEEHHCCCCEEEHHHHHEEEECCCEEEEECCCCCCCCCCCCEEEEC
FDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKEGAVLAKVPKIIKAPKGEAF
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
VRIESPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIV
EEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEE
LGEVDG
EEECCC
>Mature Secondary Structure
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQII
CCCCHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
PYTDRMDYLSAMTNNYVICHAVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLD
CCCCHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEH
IGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVKWDAPDGWIEKVKEFVPYMRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEECCCCHHHHHHHHHHHHHHH
QLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDR
HHCCHHHHCCCCCEEEEHHCCCCEEEHHHHHEEEECCCEEEEECCCCCCCCCCCCEEEEC
FDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKEGAVLAKVPKIIKAPKGEAF
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
VRIESPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIV
EEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEE
LGEVDG
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA