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The map label for this gene is nuoH

Identifier: 49188132

GI number: 49188132

Start: 5030080

End: 5031081

Strand: Reverse

Name: nuoH

Synonym: BAS5146

Alternate gene names: 49188132

Gene position: 5031081-5030080 (Counterclockwise)

Preceding gene: 49188133

Following gene: 49188131

Centisome position: 96.22

GC content: 41.42

Gene sequence:

>1002_bases
ATGATTGAAACGCTCTTACAATCACCTTCTAGCTGGACGAATTTCTTCATTTTTTTCGGATTAGCGGTGCTCCTATTATT
TGCAGTCCTTGGCTTCGTTACATATGGTATTTTGGCAGAACGGAAAGTGATGGGTTTTATGCAAGGTCGGATTGGGCCAA
ACCAAGTCGGGGGCCGGTTCGGTCTGCTGCAAACGGTAGCTGATGTTTTAAAACTACTACTAAAAGAAGATAGTATTCCG
AAAGCGGCAGATAAACCGTTGTTTATATTAGCGCCTGTTATTGCATTCGCGCCAGCATTTATGGTGCTTGCAGTCATCCC
GTTTACTGATAAATTTCAGTTCGCAGATATTGGCGTAGGCTTACTATATTACATTGCTGTTTCTGGCATTACGACGATTG
GCGTCGTAACGGGAGGATGGGCATCCAATAATAAATATTCCCTTTTAGGAGGGATGCGTGCGGCGGCGCAAATGATTTCT
TATGAAATTCCACTCGTAATGAGTGTAATTGGCATCGTTTTATTAGCTGGTAGCTTAAATTTAAATGAAATCGTAGCAGC
GCAGGAGAATGTTTGGTACATTTTCGTGCAACCAATCGGTTTCGTCGTGTTTTTAATCGCAGCGGTAGCAGAGTTAAATA
GGACGCCGTTTGATTTACCAGAAGCAGAATCGGAACTTGTTTCTGGATATCATACGGAATACTCAGGGTTTCGCTGGGCG
TTTTTCATGCTTTCAGAGTACGTATATTTTTTCGGGATGGCATCGTTAATTACAGTGCTTTTTTTAGGCGGATGGAATCC
AGTTATGTTCCTTGGATTTATTCCAGGTGCCGTATGGTTTGCTTTAAAGTTTAGCAGCGTAGTTTTTCTATTAATTTGGT
TCCGCGTTACGTTTCCGCGTATAAGAGGTGATCAGTTAATGGAGTTTGGCTGGAAAGTATTATTGCCAATTGCACTTGCA
AATATTTTCTTAACGGCATTGATTAAGGAGTTATTCTTCTAA

Upstream 100 bases:

>100_bases
ATTTGCAAATTTTACCGAAGTTATTGAAAGGTGAAAACATCGCCAATTTAATTACGATTTTAGGTGGAGTGGATATTGTA
CTTGGGGAGGTTGATGGCTA

Downstream 100 bases:

>100_bases
TCTATGAGGGGGGTGCCAGTAAGAGATGAAAGGGCTATTTAAAGGGTTAAAATATACACTAAGCAATTTGAGTAAGAAGA
AGGTGACGTATGATTATCCA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIETLLQSPSSWTNFFIFFGLAVLLLFAVLGFVTYGILAERKVMGFMQGRIGPNQVGGRFGLLQTVADVLKLLLKEDSIP
KAADKPLFILAPVIAFAPAFMVLAVIPFTDKFQFADIGVGLLYYIAVSGITTIGVVTGGWASNNKYSLLGGMRAAAQMIS
YEIPLVMSVIGIVLLAGSLNLNEIVAAQENVWYIFVQPIGFVVFLIAAVAELNRTPFDLPEAESELVSGYHTEYSGFRWA
FFMLSEYVYFFGMASLITVLFLGGWNPVMFLGFIPGAVWFALKFSSVVFLLIWFRVTFPRIRGDQLMEFGWKVLLPIALA
NIFLTALIKELFF

Sequences:

>Translated_333_residues
MIETLLQSPSSWTNFFIFFGLAVLLLFAVLGFVTYGILAERKVMGFMQGRIGPNQVGGRFGLLQTVADVLKLLLKEDSIP
KAADKPLFILAPVIAFAPAFMVLAVIPFTDKFQFADIGVGLLYYIAVSGITTIGVVTGGWASNNKYSLLGGMRAAAQMIS
YEIPLVMSVIGIVLLAGSLNLNEIVAAQENVWYIFVQPIGFVVFLIAAVAELNRTPFDLPEAESELVSGYHTEYSGFRWA
FFMLSEYVYFFGMASLITVLFLGGWNPVMFLGFIPGAVWFALKFSSVVFLLIWFRVTFPRIRGDQLMEFGWKVLLPIALA
NIFLTALIKELFF
>Mature_333_residues
MIETLLQSPSSWTNFFIFFGLAVLLLFAVLGFVTYGILAERKVMGFMQGRIGPNQVGGRFGLLQTVADVLKLLLKEDSIP
KAADKPLFILAPVIAFAPAFMVLAVIPFTDKFQFADIGVGLLYYIAVSGITTIGVVTGGWASNNKYSLLGGMRAAAQMIS
YEIPLVMSVIGIVLLAGSLNLNEIVAAQENVWYIFVQPIGFVVFLIAAVAELNRTPFDLPEAESELVSGYHTEYSGFRWA
FFMLSEYVYFFGMASLITVLFLGGWNPVMFLGFIPGAVWFALKFSSVVFLLIWFRVTFPRIRGDQLMEFGWKVLLPIALA
NIFLTALIKELFF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=288, Percent_Identity=38.1944444444444, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1788618, Length=307, Percent_Identity=43.3224755700326, Blast_Score=265, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_BACAA (C3P1E5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869511.1
- EnsemblBacteria:   EBBACT00000125692
- GeneID:   7849216
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5566
- GeneTree:   EBGT00050000003465
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36895; Mature: 36895

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x185e63bc)-; HASH(0x182bd3c4)-; HASH(0x17f78960)-; HASH(0x182df870)-; HASH(0x17aed5ec)-; HASH(0x176f5200)-; HASH(0x17668f28)-; HASH(0x17272380)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA