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The map label for this gene is polX [H]

Identifier: 49187443

GI number: 49187443

Start: 4360588

End: 4362306

Strand: Reverse

Name: polX [H]

Synonym: BAS4448

Alternate gene names: 49187443

Gene position: 4362306-4360588 (Counterclockwise)

Preceding gene: 49187444

Following gene: 49187442

Centisome position: 83.43

GC content: 38.22

Gene sequence:

>1719_bases
ATGAAAGTAAATAAAAAACAAGTAATTAAATTATTAGAGACAATCGGGCTTTTTATGGAACTAAAGGGCGCGAATCCATT
TAAAATATCTGCATTTCGTAAAGCGGCAGCAGCGCTAGAAAGTGACGATCGTAGTCTTTCTGAGATTGAAGATTTCACGA
AGATTCCGGGCATTGGAAAAGGAACAGCAGCAGTTATTCAAGAATATATAGAATCGGGAACATCTGAAGTGTTACAAGAG
CTTGAAAAAGAGGTTCCAAGTAGCTTATTACCGTTATTAAAATTGCCAGGCCTAGGTGGTAAAAAGGTAGCTAAGTTATA
TAAAGAACTTGGTGTTGTTGATATGGAGTCGCTAAAAGCGGTTTGTGAGGAAAATAAAGTACAAGCTTTAGCTGGTTTCG
GCAAAAAAACAGAAGAGAAAATATTAGAAGCAATCGATCAAGTAGGATCCCGTCCGGAGCGTTTACCAATCGCAATGGTA
TTGCCTATTGCCGGGGAAATAGAGGAGAAATTGTCGAATATTGCTGAGGTAATTCGTTTCTCTCGCGCTGGTAGTTTGCG
CCGTGTTCGTGAAACAGTAAAAGATTTAGACTTTATCATTGCAACGACAGAACCAGCTGCAGTACGTGAGCATTTACTAC
AATTTGATAATATGATTGAAGTAATCGCGAGCGGAGATACGAAAGTTTCGGTCCGTCTTCAATATGAATATGATATTTCG
ATTGATTTCCGCTTAGTAAAACCAGAAGAGTTTATTACAACTCTTCACCATTTCACAGGATCAAAAGACCATAACGTAAA
AATGCGTCAAATCGCAAAAGATAAAGGCGAGAAAATTAGTGAGTACGGTGTAGAGAACTTGGAAACAGGGGAAGTGAAAA
CATTTGAGAAGGAAGAAGAATTCTTTGCTCATTTCGGTCTTCCATTTATCCCGCCAGAAGTTCGTGAAGATGGAAAAGAA
ATTGAATTAATTAAAGAGTATCCAAACTTAATTCAGTTCTCTGATATACAAGGTGATTTACATATGCATACAACATGGAG
TGATGGTGCTTTTTCTATTGAAGAGATGGTACAAGCGTGCCGTGCTCGTGGATATAAGTTTATGGCGATTACGGATCACT
CACAATACTTGAAAGTAGCGAACGGTTTAACGAAAGAGCGCCTTCGTGAACAAGCGAAAGAAATTGAACGTATGAACGAA
AAGTATCCAGACATTACAATTTTACGCGGAATTGAAATGGACATTTTACCGGATGCCTCGCTTGATTTTGATGATGAAGT
ATTAGCAGAACTAGATTATGTCATTGGAGCAATTCACTCTAGCTTCTCACAAGACTGTGAAACGATTATGAAACGTCTTC
GTGCTGCGCTAGAGAATAAACATGTCACAATGATTGCCCATCCGACAGGACGTCTTCTTGGACGTCGTGAGGGCTACGAT
GTAGATACAGACTTATTAATCGAACTCGCAAAAGAAACAAATACAGTTTTAGAATTAAATGCGAATCCAAACCGTCTAGA
TTTAAGTGCGAAATTATTAAAACAAGCACAAGATGCTGGTGTAAAAGTAGCGATTAACACGGATGCTCATACACTTGAAA
TGTTAGAAGATATGGAAACAGGTGTAGCGGCAGCACGTAAAGGTTGGATTCAAAAAGATAACGTAATTAACACGTGGGAT
ATTGAACGTTTATTAGACTATATTAAACGTAATAAGTAA

Upstream 100 bases:

>100_bases
TCTGAAAAGGTGAAGGAACTATGGCAGACAGGTAGCAGAGTATAACTTCTCTTTTTTCGGAAAGAGAAGTTTTTTTCTAT
GAAAGAAAGGCGGGACAATG

Downstream 100 bases:

>100_bases
CACAAGGGGGACCTGCAACATGTTAGAAAGAACGTTGCGTGTATTAGAATATAATAAAGTAAAAGAACAATTACTTGAAC
ATACAGCATCTTCACTTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKVNKKQVIKLLETIGLFMELKGANPFKISAFRKAAAALESDDRSLSEIEDFTKIPGIGKGTAAVIQEYIESGTSEVLQE
LEKEVPSSLLPLLKLPGLGGKKVAKLYKELGVVDMESLKAVCEENKVQALAGFGKKTEEKILEAIDQVGSRPERLPIAMV
LPIAGEIEEKLSNIAEVIRFSRAGSLRRVRETVKDLDFIIATTEPAAVREHLLQFDNMIEVIASGDTKVSVRLQYEYDIS
IDFRLVKPEEFITTLHHFTGSKDHNVKMRQIAKDKGEKISEYGVENLETGEVKTFEKEEEFFAHFGLPFIPPEVREDGKE
IELIKEYPNLIQFSDIQGDLHMHTTWSDGAFSIEEMVQACRARGYKFMAITDHSQYLKVANGLTKERLREQAKEIERMNE
KYPDITILRGIEMDILPDASLDFDDEVLAELDYVIGAIHSSFSQDCETIMKRLRAALENKHVTMIAHPTGRLLGRREGYD
VDTDLLIELAKETNTVLELNANPNRLDLSAKLLKQAQDAGVKVAINTDAHTLEMLEDMETGVAAARKGWIQKDNVINTWD
IERLLDYIKRNK

Sequences:

>Translated_572_residues
MKVNKKQVIKLLETIGLFMELKGANPFKISAFRKAAAALESDDRSLSEIEDFTKIPGIGKGTAAVIQEYIESGTSEVLQE
LEKEVPSSLLPLLKLPGLGGKKVAKLYKELGVVDMESLKAVCEENKVQALAGFGKKTEEKILEAIDQVGSRPERLPIAMV
LPIAGEIEEKLSNIAEVIRFSRAGSLRRVRETVKDLDFIIATTEPAAVREHLLQFDNMIEVIASGDTKVSVRLQYEYDIS
IDFRLVKPEEFITTLHHFTGSKDHNVKMRQIAKDKGEKISEYGVENLETGEVKTFEKEEEFFAHFGLPFIPPEVREDGKE
IELIKEYPNLIQFSDIQGDLHMHTTWSDGAFSIEEMVQACRARGYKFMAITDHSQYLKVANGLTKERLREQAKEIERMNE
KYPDITILRGIEMDILPDASLDFDDEVLAELDYVIGAIHSSFSQDCETIMKRLRAALENKHVTMIAHPTGRLLGRREGYD
VDTDLLIELAKETNTVLELNANPNRLDLSAKLLKQAQDAGVKVAINTDAHTLEMLEDMETGVAAARKGWIQKDNVINTWD
IERLLDYIKRNK
>Mature_572_residues
MKVNKKQVIKLLETIGLFMELKGANPFKISAFRKAAAALESDDRSLSEIEDFTKIPGIGKGTAAVIQEYIESGTSEVLQE
LEKEVPSSLLPLLKLPGLGGKKVAKLYKELGVVDMESLKAVCEENKVQALAGFGKKTEEKILEAIDQVGSRPERLPIAMV
LPIAGEIEEKLSNIAEVIRFSRAGSLRRVRETVKDLDFIIATTEPAAVREHLLQFDNMIEVIASGDTKVSVRLQYEYDIS
IDFRLVKPEEFITTLHHFTGSKDHNVKMRQIAKDKGEKISEYGVENLETGEVKTFEKEEEFFAHFGLPFIPPEVREDGKE
IELIKEYPNLIQFSDIQGDLHMHTTWSDGAFSIEEMVQACRARGYKFMAITDHSQYLKVANGLTKERLREQAKEIERMNE
KYPDITILRGIEMDILPDASLDFDDEVLAELDYVIGAIHSSFSQDCETIMKRLRAALENKHVTMIAHPTGRLLGRREGYD
VDTDLLIELAKETNTVLELNANPNRLDLSAKLLKQAQDAGVKVAINTDAHTLEMLEDMETGVAAARKGWIQKDNVINTWD
IERLLDYIKRNK

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI4505931, Length=314, Percent_Identity=23.8853503184713, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64505; Mature: 64505

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNKKQVIKLLETIGLFMELKGANPFKISAFRKAAAALESDDRSLSEIEDFTKIPGIGK
CCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
GTAAVIQEYIESGTSEVLQELEKEVPSSLLPLLKLPGLGGKKVAKLYKELGVVDMESLKA
CHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
VCEENKVQALAGFGKKTEEKILEAIDQVGSRPERLPIAMVLPIAGEIEEKLSNIAEVIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
SRAGSLRRVRETVKDLDFIIATTEPAAVREHLLQFDNMIEVIASGDTKVSVRLQYEYDIS
HCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEE
IDFRLVKPEEFITTLHHFTGSKDHNVKMRQIAKDKGEKISEYGVENLETGEVKTFEKEEE
EEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHH
FFAHFGLPFIPPEVREDGKEIELIKEYPNLIQFSDIQGDLHMHTTWSDGAFSIEEMVQAC
HHHHCCCCCCCHHHHCCCCHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHH
RARGYKFMAITDHSQYLKVANGLTKERLREQAKEIERMNEKYPDITILRGIEMDILPDAS
HHCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCC
LDFDDEVLAELDYVIGAIHSSFSQDCETIMKRLRAALENKHVTMIAHPTGRLLGRREGYD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCC
VDTDLLIELAKETNTVLELNANPNRLDLSAKLLKQAQDAGVKVAINTDAHTLEMLEDMET
CCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
GVAAARKGWIQKDNVINTWDIERLLDYIKRNK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVNKKQVIKLLETIGLFMELKGANPFKISAFRKAAAALESDDRSLSEIEDFTKIPGIGK
CCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
GTAAVIQEYIESGTSEVLQELEKEVPSSLLPLLKLPGLGGKKVAKLYKELGVVDMESLKA
CHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
VCEENKVQALAGFGKKTEEKILEAIDQVGSRPERLPIAMVLPIAGEIEEKLSNIAEVIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
SRAGSLRRVRETVKDLDFIIATTEPAAVREHLLQFDNMIEVIASGDTKVSVRLQYEYDIS
HCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEE
IDFRLVKPEEFITTLHHFTGSKDHNVKMRQIAKDKGEKISEYGVENLETGEVKTFEKEEE
EEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHH
FFAHFGLPFIPPEVREDGKEIELIKEYPNLIQFSDIQGDLHMHTTWSDGAFSIEEMVQAC
HHHHCCCCCCCHHHHCCCCHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHH
RARGYKFMAITDHSQYLKVANGLTKERLREQAKEIERMNEKYPDITILRGIEMDILPDAS
HHCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCC
LDFDDEVLAELDYVIGAIHSSFSQDCETIMKRLRAALENKHVTMIAHPTGRLLGRREGYD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCC
VDTDLLIELAKETNTVLELNANPNRLDLSAKLLKQAQDAGVKVAINTDAHTLEMLEDMET
CCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
GVAAARKGWIQKDNVINTWDIERLLDYIKRNK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]