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The map label for this gene is mutS2

Identifier: 49187442

GI number: 49187442

Start: 4358208

End: 4360568

Strand: Reverse

Name: mutS2

Synonym: BAS4447

Alternate gene names: 49187442

Gene position: 4360568-4358208 (Counterclockwise)

Preceding gene: 49187443

Following gene: 49187441

Centisome position: 83.4

GC content: 38.8

Gene sequence:

>2361_bases
ATGTTAGAAAGAACGTTGCGTGTATTAGAATATAATAAAGTAAAAGAACAATTACTTGAACATACAGCATCTTCACTTGG
TCGTGACAAAGTGAAGCATTTAGTGCCGAGCACTGATTTTGAAGAAATTGTAGAAATGCAAGATACAACGGATGAAGCAG
CGAAAGTTATTCGTCTAAAGGGTAGTGCACCATTAGGTGGTATTACGGATATTCGCTCTAATGTGAAGCGTGCAAAGATT
GGAAGTATGTTAAGTCCAAATGAACTACTTGATATTGCCAATACGATGTATGGTAGTCGCAATATGAAACGTTTCATTGA
AGATATGGTTGATAATGGTGTTGAGCTTCCCATTTTAGAAACTCATGTCGCTCAAATTGTATCTTTATATGATTTAGAAA
AGAAAATTACAAATTGTATTGGTGATGGTGGGGAAGTAGTCGATAGCGCAAGTGATAAACTGCGCGGTATTCGTACTCAA
ATTCGTACTGCAGAAAGCCGTATTCGTGAAAAGTTAGAAAACATGACGCGTTCTTCAAACGCGCAAAAGATGCTGTCTGA
CTCGATTGTAACGATTCGTAATGAACGTTACGTAATCCCAGTAAAACAAGAATACCGCGGCGTATATGGCGGTATTGTTC
ATGATCAATCAGCTTCTGGACAAACGTTATTTATTGAACCGCAAGTCATTGTAGAATTAAATAACGCACTCCAAGAAGCA
CGTGTGAAAGAAAAACAAGAAATCGAACGCATCTTATTAATGTTAACAGAAGAAGTGGCAGTAGAAGCGGATATCGTTTT
ATCAAACGTAGAAGTAGTTGCAAATCTTGACTTCATATTTGCGAAAGCTTTTTATGCGAAGCGTATTAAAGCAACGAAGC
CAATCGTAAATAACGAGCGTTATATGGATTTAAGACAGGCACGTCATCCGCTTATTGATCCAGAAGTTATCGTGCCAAAT
AACATTATGCTAGGTAAAGATTTCACGACAATTGTTATTACAGGACCGAATACAGGTGGTAAAACAGTTACGCTGAAAAC
AGTTGGTATTTGTGTGTTAATGGCGCAATCTGGCCTTCATATTCCAGTAATGGATGAGTCAGAGATTTGTGTATTTAAAA
ATATATTTGCTGATATCGGTGATGAGCAATCGATTGAACAAAGTTTAAGTACGTTCTCCTCACATATGGTGAACATTGTT
GATATTTTAGAAAAAGCTGATTTTGAAAGCTTAGTTTTATTCGATGAATTAGGTGCTGGAACAGATCCACAAGAAGGGGC
TGCACTTGCCATTTCGATTTTAGATGAAGTATGTAATCGCGGTGCTCGCGTTGTTGCTACGACGCATTACCCAGAATTAA
AAGCATACGGATATAACCGTGAGCAAGTTATTAATGCGAGTGTTGAGTTCGATGTAAATACATTAAGCCCAACGCATAAA
TTATTAATCGGTGTACCAGGACGTAGTAATGCCTTTGAAATTTCGAAACGTCTTGGATTATCTAATCGCGTCATTGATCA
AGCTCGTAACCACATTAGTACCGATACAAATAAAATTGAAAATATGATTGCGAAGTTAGAAGAAAGTCAAAAGAACGCAG
AGCGTGACTGGAACGAAGCAGAAGCACTTCGCAAGCAATCTGAAAAACTGCATCGCGAATTACAACGTCAAATTATTGAA
TTTAACGAAGAGCGTGATGAACGATTATTAAAAGCGCAAAAAGAAGGGGAAGAAAAAGTCGAAGCTGCAAAGAAAGAAGC
AGAAGGCATTATTCAAGAACTTCGTCAATTGCGTAAAGCACAGCTTGCAAACGTGAAAGATCACGAGCTAATTGAAGCGA
AGAGCCGTCTAGAAGGCGCAGCACCAGAGCTTGTGAAGAAACAAAAAGTAAACGTGAAAAATACTGCGCCGAAACAACAG
TTACGTGCAGGTGATGAAGTAAAAGTATTAACGTTCGGTCAAAAAGGTCAATTGCTTGAAAAAGTAAGCGATACAGAGTG
GAGCGTACAAATTGGTATTCTGAAGATGAAAGTAAAAGAATCTAATATGGAATACATTAATACACCGAAACAAACAGAGA
AAAAAGCAGTTGCAACAGTAAAAGGTAGAGACTATCATGTTTCGCTAGAGCTTGATCTTCGTGGTGAACGATTTGAAAAT
GCAATGGCGCGCGTTGAGAAATACTTAGACGATGCCCAGCTTGCAAGCTATCCTCGTGTATCAATCATTCACGGTAAAGG
AACAGGAGCACTTCGCCAAGGTGTTCAAGATTACTTGAAGAAGCACCGCGGTGTAAAAACATTCCGTTACGGTGACATGG
GCGAGGGAGGCCTAGGCGTAACAGTTGTCGAATTAAAATAG

Upstream 100 bases:

>100_bases
AAAGGTTGGATTCAAAAAGATAACGTAATTAACACGTGGGATATTGAACGTTTATTAGACTATATTAAACGTAATAAGTA
ACACAAGGGGGACCTGCAAC

Downstream 100 bases:

>100_bases
AAAACAACGAAACAAAGGGGAAACCATTATATGTTTATGGACAAACTTGCAAAAGTATTGTTAGCTTGTTGTGGAATATT
TTTGGTGATTGGGGTTATTT

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNAQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTHK
LLIGVPGRSNAFEISKRLGLSNRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK

Sequences:

>Translated_786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNAQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTHK
LLIGVPGRSNAFEISKRLGLSNRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK
>Mature_786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNAQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTHK
LLIGVPGRSNAFEISKRLGLSNRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=591, Percent_Identity=25.3807106598985, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4557761, Length=194, Percent_Identity=31.9587628865979, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI36949366, Length=227, Percent_Identity=28.1938325991189, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4504191, Length=309, Percent_Identity=26.8608414239482, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI26638666, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI4505253, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI26638664, Length=294, Percent_Identity=27.5510204081633, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI262231786, Length=218, Percent_Identity=30.2752293577982, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1789089, Length=333, Percent_Identity=27.3273273273273, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=363, Percent_Identity=25.6198347107438, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17534743, Length=341, Percent_Identity=26.099706744868, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17539736, Length=214, Percent_Identity=26.6355140186916, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=278, Percent_Identity=25.5395683453237, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=319, Percent_Identity=25.705329153605, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=232, Percent_Identity=31.4655172413793, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=187, Percent_Identity=31.5508021390374, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321109, Length=268, Percent_Identity=29.4776119402985, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=268, Percent_Identity=26.4925373134328, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320047, Length=184, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664545, Length=270, Percent_Identity=29.2592592592593, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24584320, Length=280, Percent_Identity=27.5, Blast_Score=88, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_BACAA (C3PAE0)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868830.1
- ProteinModelPortal:   C3PAE0
- EnsemblBacteria:   EBBACT00000129781
- GeneID:   7848841
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4805
- GeneTree:   EBGT00050000000349
- ProtClustDB:   PRK00409
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 88190; Mature: 88190

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCHHHHHHEEEEE
GSAPLGGITDIRSNVKRAKIGSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILE
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
THVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
HHHHHHCCCEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHEEHHHHHHHHH
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YMDLRQARHPLIDPEVIVPNNIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCCEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCE
IPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTHK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEEEEEEEEEECCCCCCE
LLIGVPGRSNAFEISKRLGLSNRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
EALRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQLRAGDEVKVLTFGQKGQLLE
HHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHH
KVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
HHCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHEEECCCEEEEEEEEECCCHHHHH
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCE
TVVELK
EEEEEC
>Mature Secondary Structure
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKHLVPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCHHHHHHEEEEE
GSAPLGGITDIRSNVKRAKIGSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILE
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
THVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
HHHHHHCCCEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHEEHHHHHHHHH
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YMDLRQARHPLIDPEVIVPNNIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCCEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCE
IPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTHK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEEEEEEEEEECCCCCCE
LLIGVPGRSNAFEISKRLGLSNRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
EALRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQLRAGDEVKVLTFGQKGQLLE
HHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHH
KVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
HHCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHEEECCCEEEEEEEEECCCHHHHH
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCE
TVVELK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA