Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 49187355

GI number: 49187355

Start: 4271528

End: 4272280

Strand: Reverse

Name: hemD [H]

Synonym: BAS4360

Alternate gene names: 49187355

Gene position: 4272280-4271528 (Counterclockwise)

Preceding gene: 49187356

Following gene: 49187354

Centisome position: 81.71

GC content: 37.98

Gene sequence:

>753_bases
ATGAACGCTCTCGCTGGCAAAACGGTATTGATTACACGTGCTCAGCACCAAGCAAAACAAATGAGTGTAGCGGTGAAAGA
AAAGAGCGGAATTCCATTGGAAATTCCGCTTTTGCGTATGGAAGGTATGTTTCATAGGCAAATTCAACATATAGCAGGGC
AGTTACATTCGTATGATTGGGTTATTTTTACGAGTAAAAATGGGGTAGCTTTTTTTCTAGATTGTTTAGGAAAGAAGCTA
CCCGTAACGACTAAAATTGCTGCAGTAGGCGTGAAAACAAAGTTAGAGTTAGAAAAGCGAGGCTATCATGTAGACTTTGT
TCCAACTTCATTTGTTGCAGAAGCATTTGCAGAAGAGTTTGTAAAAAGATTAAGTGGAAACGAACGTATTTTATTTCCGA
AAGGGAATTTAGCAAGAGAGGTAATTCCGGTTGCACTTCGGGAAATTGGTGTTTCTCTAGATGAGCTAATCGTATACGGT
ACGAAAGTGAATATAGAAAAAAAGCAAGAGCTTATAGCAGCATTGAAGTTAGGGAAAGTAGACATTATTACATTTACGAG
CCCTTCAACTGTTACTAGTTTTGTTCGTTTACTTGAGGGTACAAACTGGAGAGAATGGACAAAAAAATGTACAATTGCTT
GTATAGGGCCTATTACGGAAAAAGAGGCGAGCCTTTATTTTCCGCATGTTATTATGCCGAAAGAGTACACTGTAGAAGCA
TTACTACAATGCGTTTGTGAATCTATAAAATAA

Upstream 100 bases:

>100_bases
GGAACTGATCCAGAGAAAGTAGGATTAGAGGCTGCGGACCGTTTAATTAAGCAAGGCGCAAAAGAACTCATTCTTGCTGC
AAATAAGGGGCAACAATAAT

Downstream 100 bases:

>100_bases
AAGAATGGGGATAGAAATCTATGAACTCTTTACAATTTAATCGTCATCGTCGCTTAAGACAAAGCGGGGGCATGCGTGCG
CTTGTGCGTGAAACGTTTTT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMFHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDCLGKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEAFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Sequences:

>Translated_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMFHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDCLGKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEAFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK
>Mature_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMFHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDCLGKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEAFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27973; Mature: 27973

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMFHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDCLGKKLPVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEAFAEEF
EEEECCCCHHHEEHHCCCCCCCCHHHEEECCCEEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYGTKVNIEKKQELIAALKLGKV
HHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHEEECCEECHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCCCHHH
LLQCVCESIK
HHHHHHHHCC
>Mature Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMFHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDCLGKKLPVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEAFAEEF
EEEECCCCHHHEEHHCCCCCCCCHHHEEECCCEEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYGTKVNIEKKQELIAALKLGKV
HHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHEEECCEECHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCCCHHH
LLQCVCESIK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]