Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 49187297

GI number: 49187297

Start: 4212313

End: 4214496

Strand: Reverse

Name: relA [H]

Synonym: BAS4302

Alternate gene names: 49187297

Gene position: 4214496-4212313 (Counterclockwise)

Preceding gene: 49187298

Following gene: 49187296

Centisome position: 80.6

GC content: 37.18

Gene sequence:

>2184_bases
ATGGCAAATGAGCAGGTACTAACAGCTGAACAGGTACTCGAGAAAGCAAGTCAATATTTAGTGGATGAAGATATTGAGCT
AGTAGCACGTGCCTATGAATATGCACGCGATGCACATAGCGAACAATACAGAAAATCGGGTGAACCGTACATTATTCATC
CAATTCAAGTTGCAGGTGTTTTAGTTGATTTACACATGGATCCAGCTACAGTATCAGCAGGTTTCTTACATGATGTAGTA
GAAGATACAGAGATTACATTAGAAGATATTGAACGGGAATTTAATAAAGAAATTGCTATGCTTGTCGATGGTGTGACAAA
GCTCGGAAAGATTAAATATAAATCTCATGAGCAACAACAAGCAGAAAACCATCGCAAAATGTTTATTGCAATGGCTCAAG
ATATTCGAGTTATTTTAATTAAACTAGCTGATCGTCTTCATAACATGCGTACATTGAAACATTTGCCTCAAGAGAAGCAG
CGTCGCATTGCGAATGAAACGTTAGAAATCTTTGCACCTTTGGCACATAGACTCGGAATTAGTACTATTAAATGGGAGCT
AGAGGATACGTCACTTCGCTATTTAAATCCACAGCAATATTATCGTATTGTAAATTTAATGAAGCGTAAACGTGCAGAAC
GTGAAGAGTATTTAGACGAAGTAATGACTGGTATTCGTGAGAAATTAGACGAAGTTGCAATTCAACCAGAGATTTCTGGA
AGACCAAAACATATTTACAGTATTTATCGTAAAATGGCACTGCAAAATAAACAGTTCAATGAAATTTACGATTTATTAGC
TGTACGTGTCGTTGTAAATAGTATTAAAGATTGTTATGCAGTACTTGGAATTATTCATACGTGCTGGAAGCCGATGCCAG
GTCGTTTTAAGGATTATATTGCAATGCCGAAAGCAAATCTATATCAATCTCTTCATACGACTGTAATTGGACCGAAAGGT
GATCCGCTTGAAGTGCAAATTCGTACGAAAGAAATGCATGAGATTGCAGAATTCGGGATCGCGGCACACTGGGCGTATAA
AGAAGGAAAAACAGCAGAAACAACAGGTACATTAGAGAAGAAACTTACATGGTTCCGTCAAATATTAGAATGGCAAAATG
AAGCTTCTAATGCAGAAGAGTTTATGGAGTCGTTAAAAATTGATTTATTCTCTGACATGGTATTCGTCTTTACACCGAAA
GGCGATGTAATGGAATTGCCACTTGGATCTGTTCCAATTGACTTTGCATATCGTGTGCATTCAGAGATTGGGAATAAAAC
AATTGGTGCAAAAGTAAACGGGAAAATGGTGACACTTGACTATAAATTAAAAACAGGTGACATCATTGAAATTTTAACAT
CGAAACATTCGTATGGACCAAGTCAAGATTGGGTGAAACTAGCTCAAACATCTCATGCAAAAAACAAAATACGTCAATTC
TTTAAGAAGCAACGTAGAGATGAAAATATTGAAAAAGGCCGTGAACTTGTTGAGAAAGAAGTGCGGAGCCTAGAGTATGA
GATGAAAGAAGTGTTAGCTCCTGACAATTTAAAACGTGTTGCTGAAAAATTCAACTTTGCAAATGAAGAAGATATGTTTG
CAGCAGTTGGATATAATGGCATCACTGCATCACAAATTGTTACGCGACTAACGGACAAGTTCCGTAAGCAACGTGAAGAA
GAAGAGATTGTTGAAGTTAAAGAAGTTCGTAAACCGATGAAAATTCGAAAATGGGATTCTGGCGTTAAAGTGAGCGGTGC
GGATAATTTATTAATTCGTTTATCAAAATGCTGTAACCCAGTACCTGGTGATGATATCGTTGGATATATTACGAAAGGCC
GAGGCGTATCAATTCACCGCCGTGATTGTGTAAATGTTCATACAGAAGAAGCGATAGAACGTTTATTAGAAGTAGAGTGG
GAAGGTAGTCCTGAAAAAGAAATTGAGTATAACGTTGATATTGAAATTTCAGGTTACGATCGCCGTGGTTTATTAAACGA
AGTATTACAAGCTGTTACAGAGACGAAAACGTACATTTCAGCAGTTTCTGGTAGAAGTGACCGTAATAAGATGGCGACAA
TTAATATGTCAATCTCTATTCGTAACTTACAGCACTTGAAAAAAGTAGTAGAACGCATTAAACGTGTTCCAGAAATTTAT
GCAGTACGACGCATGATGCATTAA

Upstream 100 bases:

>100_bases
CTTTTCCTTTTCACAATTCACAATCATTGGGTTATAATGATAGAATATAATTTATTCTATTTAATAAAGATAAAGTCAAT
TTTCAATAAAAGGTGATTCG

Downstream 100 bases:

>100_bases
TAGGGAGTGTAGAAAAGATGAGAGTTGTTTTACAACGATCAAAAGAAGCGTCTGTCACAGTAGACGGTGAGATCGTAGGA
CAAATTCCGTTCGGTTTAAC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MANEQVLTAEQVLEKASQYLVDEDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGVLVDLHMDPATVSAGFLHDVV
EDTEITLEDIEREFNKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRIANETLEIFAPLAHRLGISTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTGIREKLDEVAIQPEISG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKG
DPLEVQIRTKEMHEIAEFGIAAHWAYKEGKTAETTGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPK
GDVMELPLGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQF
FKKQRRDENIEKGRELVEKEVRSLEYEMKEVLAPDNLKRVAEKFNFANEEDMFAAVGYNGITASQIVTRLTDKFRKQREE
EEIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIVGYITKGRGVSIHRRDCVNVHTEEAIERLLEVEW
EGSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKRVPEIY
AVRRMMH

Sequences:

>Translated_727_residues
MANEQVLTAEQVLEKASQYLVDEDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGVLVDLHMDPATVSAGFLHDVV
EDTEITLEDIEREFNKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRIANETLEIFAPLAHRLGISTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTGIREKLDEVAIQPEISG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKG
DPLEVQIRTKEMHEIAEFGIAAHWAYKEGKTAETTGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPK
GDVMELPLGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQF
FKKQRRDENIEKGRELVEKEVRSLEYEMKEVLAPDNLKRVAEKFNFANEEDMFAAVGYNGITASQIVTRLTDKFRKQREE
EEIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIVGYITKGRGVSIHRRDCVNVHTEEAIERLLEVEW
EGSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKRVPEIY
AVRRMMH
>Mature_726_residues
ANEQVLTAEQVLEKASQYLVDEDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGVLVDLHMDPATVSAGFLHDVVE
DTEITLEDIEREFNKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQR
RIANETLEIFAPLAHRLGISTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTGIREKLDEVAIQPEISGR
PKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKGD
PLEVQIRTKEMHEIAEFGIAAHWAYKEGKTAETTGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKG
DVMELPLGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFF
KKQRRDENIEKGRELVEKEVRSLEYEMKEVLAPDNLKRVAEKFNFANEEDMFAAVGYNGITASQIVTRLTDKFRKQREEE
EIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIVGYITKGRGVSIHRRDCVNVHTEEAIERLLEVEWE
GSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKRVPEIYA
VRRMMH

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=707, Percent_Identity=40.4526166902404, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=39.2185238784371, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=37.1212121212121, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650996, Length=127, Percent_Identity=35.4330708661417, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84066; Mature: 83935

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEQVLTAEQVLEKASQYLVDEDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGV
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEE
LVDLHMDPATVSAGFLHDVVEDTEITLEDIEREFNKEIAMLVDGVTKLGKIKYKSHEQQQ
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRIANETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
STIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTGIREKLDEVAIQPEISG
CCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANLYQSLHTTVIGPKGDPLEVQIRTKEMHEIAEFGIAAHWAYKEGKTAETTGTLEK
CCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCHHHEEECCCCCCCCHHHHHHH
KLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKGDVMELPLGSVPIDFAYRVH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHHH
SEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQF
HHHCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQRRDENIEKGRELVEKEVRSLEYEMKEVLAPDNLKRVAEKFNFANEEDMFAAVGYNG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCC
ITASQIVTRLTDKFRKQREEEEIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHHHHHCCC
VPGDDIVGYITKGRGVSIHRRDCVNVHTEEAIERLLEVEWEGSPEKEIEYNVDIEISGYD
CCCCCCEEEEECCCCCEEECHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
RRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKRVPEIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCHHHH
AVRRMMH
HHHHHCC
>Mature Secondary Structure 
ANEQVLTAEQVLEKASQYLVDEDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGV
CCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEE
LVDLHMDPATVSAGFLHDVVEDTEITLEDIEREFNKEIAMLVDGVTKLGKIKYKSHEQQQ
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRIANETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
STIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTGIREKLDEVAIQPEISG
CCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANLYQSLHTTVIGPKGDPLEVQIRTKEMHEIAEFGIAAHWAYKEGKTAETTGTLEK
CCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCHHHEEECCCCCCCCHHHHHHH
KLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKGDVMELPLGSVPIDFAYRVH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHHH
SEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQF
HHHCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQRRDENIEKGRELVEKEVRSLEYEMKEVLAPDNLKRVAEKFNFANEEDMFAAVGYNG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCC
ITASQIVTRLTDKFRKQREEEEIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHHHHHCCC
VPGDDIVGYITKGRGVSIHRRDCVNVHTEEAIERLLEVEWEGSPEKEIEYNVDIEISGYD
CCCCCCEEEEECCCCCEEECHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
RRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKRVPEIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCHHHH
AVRRMMH
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]