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The map label for this gene is apt

Identifier: 49187298

GI number: 49187298

Start: 4214707

End: 4215219

Strand: Reverse

Name: apt

Synonym: BAS4303

Alternate gene names: 49187298

Gene position: 4215219-4214707 (Counterclockwise)

Preceding gene: 49187299

Following gene: 49187297

Centisome position: 80.62

GC content: 37.43

Gene sequence:

>513_bases
ATGGATTTCAAGCAACATATCGCAATTGTACCGGACTATCCAAAAGAAGGTATCGTGTTTAAAGACATTACACCGTTAAT
GAACGACGGTAAAGCATACAAAGCAGCAACAGATGCAATCGTTGAGTATGCAAAAGAGAGAGACATCGACCTTGTAGTAG
GTCCAGAAGCTCGTGGTTTTATTATTGGTTGCCCAGTTTCTTACGCATTAGAAGTAGGATTTGCGCCAGTTCGTAAATTA
GGAAAATTACCACGTGAAGTAATTACAGTTGACTACGGTAAAGAATATGGTAAAGATGTTTTAACAATCCATAAAGATGC
AATTAAACCAGGCCAACGCGTATTAATTACAGATGATCTATTAGCTACAGGTGGAACAATCGAAGCGACAATTAAGCTAG
TTGAAGAGCTAGGCGGAGTTGTAGCAGGAATTGCATTCTTAGTAGAACTTACTTACTTAGATGGTCGTAAAATGTTAGAT
GGTTACGATGTATTAGTATTAGAAAAATACTAA

Upstream 100 bases:

>100_bases
ATACATGGTTTGAAACGATTCGTAATCATAAAGAAGTAGAACAGCTAGGGTAAAGGATTTGTATTTACAAACCTTTTAGA
TCTGAGGAGGATTCAGAAAT

Downstream 100 bases:

>100_bases
TCGCTATATAGGTAAAACTACGGTGATAAGAAGTACCCGTGAATCTCTTGGAGAGGAGCGGGTACTTTTGTATAATTGAA
CAAAAAATTATGGTGAAATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY

Sequences:

>Translated_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY
>Mature_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=40.5882352941176, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=41.9354838709677, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=56.3291139240506, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=169, Percent_Identity=42.603550295858, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=155, Percent_Identity=42.5806451612903, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=31.1688311688312, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=43.75, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BACAA (C3P995)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868694.1
- ProteinModelPortal:   C3P995
- SMR:   C3P995
- EnsemblBacteria:   EBBACT00000126209
- GeneID:   7852247
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4655
- GeneTree:   EBGT00050000001499
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18644; Mature: 18644

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDLVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEE
IIGCPVSYALEVGFAPVRKLGKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHCCCHHEEEEECCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLDGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECC
>Mature Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDLVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEE
IIGCPVSYALEVGFAPVRKLGKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHCCCHHEEEEECCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLDGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA