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The map label for this gene is gcvPA

Identifier: 49187127

GI number: 49187127

Start: 4049992

End: 4051335

Strand: Reverse

Name: gcvPA

Synonym: BAS4130

Alternate gene names: 49187127

Gene position: 4051335-4049992 (Counterclockwise)

Preceding gene: 49187128

Following gene: 49187126

Centisome position: 77.48

GC content: 38.39

Gene sequence:

>1344_bases
ATGTTGCATCGTTATCTTCCAATGACAGAAGAAGACAAAAAAGAAATGTTACAAACGATCGGCGTTCAAACGATCGATGA
GTTATTCTCTGATATTCCAGAGAGTGTTCGTTTTAAAGGGGATTTAAAAATTAAAGAAGCAAAATCAGAGCCAGAGCTTT
TAAAAGAGTTATCTCAAATGGCTAGTAAAAATGCGAACTTAAAAGAATACGCTTCTTTCTTAGGAGCTGGTGTATACGAT
CATTACGCTCCAGTAATTGTAGATCATGTTATCTCTCGCTCAGAATTTTATACAGCTTACACGCCATACCAACCAGAAAT
TTCACAAGGGGAATTACAAGCAATCTTTGAATTCCAAACGATGATTTGTGAATTAACAGGAATGGATGTAGCAAACTCTT
CTATGTACGACGGTGGTACAGCTTTAGCTGAAGCGGCAATGCTAGCGGCTGGCCATACTCGTAAAAAGAAAATTCTTGTA
TCTAGTGCAGTGCACCCAGAATCAAGAGCAGTACTTGAAACATATGCAAAAGGTCAACATCTTGAAGTTGTTGAAATTAA
TCATAAAGATGGTGTTACAGATTTAGACGTATTACAAAGTGAAGTAGATGATACTGTTGCTTGTGTAATCGTTCAATATC
CAAACTTCTTCGGACAAGTTGAAAAATTAGCTGATATTGAAAAAATCGTTCATCAACAAAAATCATTATTTATCGTTTCT
TCAAATCCATTATCATTAGGCGCATTAACACCACCAGGAAAATTTGGTGCTGATATTGTAATCGGTGATGCACAGCCATT
TGGTATTCCAACGCAGTTTGGTGGACCGCACTGTGGTTACTTTGCAACAACGAAAGCATTTATGCGTAAAATTCCAGGAC
GTCTTGTTGGACAAACTGTAGATTCAGATGGGAAACGTGGGTTTGTATTAACGTTACAGGCACGTGAACAGCATATCCGC
CGTGATAAAGCGACATCTAACATTTGTTCAAACCAAGCGTTAAATGCATTAGCAGCTTCTGTTGCAATGACGGCACTTGG
TAAACAAGGTGTGAAAGAAATGGCACGTCAAAACATTTCTAAAGCGCAATACGCAAAACGTCAATTCGAAGCGAAAGGCT
TCACTGTAACATTTGCTGGTCCATTCTTCAATGAGTTCGTTGTAGATTGTAAGCGTCCAGTGAAAGAAGTAAACGATGCA
TTATTACAAAAGAATATTATCGGCGGTTACGATCTAGGCCGTGATTATAAAGAGCATGAGAACCATATGCTTGTAGCAGT
AACTGAGCTTCGTACAAAAGAGGAAATTGACACACTTGTAAACGAAATGGGGGCTATCCAATGA

Upstream 100 bases:

>100_bases
CAGAAGTAGAAATTGAAATTCGTAATAAACGCGTCAAAGCAGTAGTTGTTCCAACACCATTTTATAAACGTTCAAAGTAA
CGGGGAGAGGGGTAGATTTC

Downstream 100 bases:

>100_bases
AGAACCAAGACCAAGCACTTATCTTTGAAGTGAGTAAAGAAGGACGCATAGGATATAGCTTACCAAAATTAGATGTAGAA
GAAGTGAAACTAGAAGATGT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQMASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ

Sequences:

>Translated_447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQMASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ
>Mature_447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQMASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=38.4803921568627, Blast_Score=285, Evalue=8e-77,
Organism=Escherichia coli, GI1789269, Length=394, Percent_Identity=33.248730964467, Blast_Score=201, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=360, Percent_Identity=39.7222222222222, Blast_Score=244, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=368, Percent_Identity=40.2173913043478, Blast_Score=262, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24645648, Length=358, Percent_Identity=38.8268156424581, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_BACAA (C3P8D4)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868517.1
- ProteinModelPortal:   C3P8D4
- SMR:   C3P8D4
- EnsemblBacteria:   EBBACT00000126022
- GeneID:   7848443
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4466
- GeneTree:   EBGT00050000001780
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49422; Mature: 49422

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ASKNANLKEYASFLGAGVYDHYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSSAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHCCCCC
LEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
EEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCCEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DSDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDALLQKNIIGGYDLGRDYKEHE
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NHMLVAVTELRTKEEIDTLVNEMGAIQ
CCEEEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ASKNANLKEYASFLGAGVYDHYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSSAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHCCCCC
LEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
EEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCCEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DSDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDALLQKNIIGGYDLGRDYKEHE
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NHMLVAVTELRTKEEIDTLVNEMGAIQ
CCEEEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA