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The map label for this gene is gcvPB [H]

Identifier: 49187126

GI number: 49187126

Start: 4048520

End: 4049995

Strand: Reverse

Name: gcvPB [H]

Synonym: BAS4129

Alternate gene names: 49187126

Gene position: 4049995-4048520 (Counterclockwise)

Preceding gene: 49187127

Following gene: 49187125

Centisome position: 77.46

GC content: 38.96

Gene sequence:

>1476_bases
ATGAAGAACCAAGACCAAGCACTTATCTTTGAAGTGAGTAAAGAAGGACGCATAGGATATAGCTTACCAAAATTAGATGT
AGAAGAAGTGAAACTAGAAGATGTGTTTGAGAGCGATTATATTCGAGTAGAAGATGCAGAGCTACCAGAAGTATCTGAAC
TTGATATTATGCGCCACTATACAGCACTTTCAAACCGTAACCACGGCGTTGATTCTGGGTTCTATCCACTTGGATCTTGT
ACGATGAAATATAATCCGAAAATTAATGAGAGTGTAGCTCGTTTCGCAGGATTTGCAAATATTCATCCGTTGCAAGACGA
GAAGACAGTACAAGGTGCAATGGAATTAATGTACGATTTACAAGAGCATTTAATTGAAATTACAGGTATGGATACTGTTA
CATTACAACCAGCAGCTGGTGCACACGGAGAATGGACAGGCTTAATGTTAATTCGTGCATACCATGAAGCAAATGGTGAC
TTTAACCGTACGAAAGTAATTGTTCCTGACTCTGCTCACGGAACGAATCCAGCATCTGCAACTGTAGCTGGTTTTGAAAC
AATTACAGTAAAATCAAATGAACATGGTCTTGTTGACTTAGAAGATTTAAAACGTGTTGTAAATGAAGAAACAGCAGCAC
TTATGTTAACAAATCCTAATACATTAGGTTTATTTGAAGAAAACATTTTAGAAATGGCAGAAATCGTCCATAATGCAGGC
GGTAAATTATACTATGATGGTGCAAACTTAAATGCAGTATTAAGCCAAGCGCGCCCAGGAGATATGGGATTTGACGTTGT
GCATTTAAACCTTCATAAAACATTTACAGGTCCTCACGGCGGCGGTGGCCCAGGTTCTGGTCCAGTAGGTGTGAAAGCTG
ATTTAATTCCGTACTTACCAAAACCAATTTTAGAGAAAACGGAAAATGGCTATCACTTTAACTATGATCGTCCAGAAGCA
ATTGGGCGCGTAAAACCATTCTATGGTAACTTCGGAATTAATGTTCGTGCATACACATACATTCGTTCTATGGGTCCAGA
TGGCTTGCGTGCAGTAACGGAGTATGCGGTATTAAATGCGAACTATATGATGAGAAGATTAGCACCATTCTATGATCTTC
CATTCGATAGACATTGTAAGCATGAGTTTGTATTATCAGGTCGTCGTCAAAAGAAACTTGGTGTACGTACATTAGATATC
GCAAAACGCCTGCTTGATTTCGGTTACCATCCACCAACGATTTACTTCCCGTTAAATGTGGAAGAATGTATTATGATTGA
GCCGACAGAAACAGAATCAAAAGAAACTTTAGACGGTTTCATTGATAAGATGATTCAAATCGCTAAAGAAGTAGAAGAAA
ATCCAGAAGTTGTACAAGAAGCACCGCATACAACAGTCATTAAACGTTTAGATGAAACGATGGCTGCACGTAAACCAGTT
TTACGTTATGCAAAGCCAGCTCCTGTACAAGTTTGA

Upstream 100 bases:

>100_bases
GTGATTATAAAGAGCATGAGAACCATATGCTTGTAGCAGTAACTGAGCTTCGTACAAAAGAGGAAATTGACACACTTGTA
AACGAAATGGGGGCTATCCA

Downstream 100 bases:

>100_bases
TTAGAATAACAAAAGAAGAACTCGCTATATGCGGGTTCTTTTTTTGTATGGAGAATTAGTGCAGAAATAGTGAAGAAAAT
GTTAAAAAATTATATTTTTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDLQEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGD
FNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLPKPILEKTENGYHFNYDRPEA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNANYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPV
LRYAKPAPVQV

Sequences:

>Translated_491_residues
MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDLQEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGD
FNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLPKPILEKTENGYHFNYDRPEA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNANYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPV
LRYAKPAPVQV
>Mature_491_residues
MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDLQEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGD
FNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLPKPILEKTENGYHFNYDRPEA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNANYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPV
LRYAKPAPVQV

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=42.5581395348837, Blast_Score=295, Evalue=8e-80,
Organism=Escherichia coli, GI1789269, Length=429, Percent_Identity=41.025641025641, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17535605, Length=430, Percent_Identity=40.2325581395349, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI32564013, Length=387, Percent_Identity=41.0852713178295, Blast_Score=261, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=43.2183908045977, Blast_Score=327, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24645648, Length=411, Percent_Identity=42.3357664233577, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54866; Mature: 54866

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
TALSNRNHGVDSGFYPLGSCTMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDL
HHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGDFNRTKVIVPDSAHGTNPASA
HHHHEECCCCCEEEECCCCCCCCCCHHEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEECCHHCCC
KPILEKTENGYHFNYDRPEAIGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNA
CHHHHCCCCCEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHH
NYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCHHHCCCCCCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPV
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
LRYAKPAPVQV
HHCCCCCCCCC
>Mature Secondary Structure
MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
TALSNRNHGVDSGFYPLGSCTMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDL
HHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGDFNRTKVIVPDSAHGTNPASA
HHHHEECCCCCEEEECCCCCCCCCCHHEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEECCHHCCC
KPILEKTENGYHFNYDRPEAIGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNA
CHHHHCCCCCEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHH
NYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCHHHCCCCCCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPV
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
LRYAKPAPVQV
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]