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The map label for this gene is kbl [C]

Identifier: 49187024

GI number: 49187024

Start: 3961306

End: 3962493

Strand: Reverse

Name: kbl [C]

Synonym: BAS4026

Alternate gene names: 49187024

Gene position: 3962493-3961306 (Counterclockwise)

Preceding gene: 49187025

Following gene: 49187023

Centisome position: 75.78

GC content: 38.22

Gene sequence:

>1188_bases
ATGAATCAACCGTGGCGCACACATCTTCAAACTAAGTTAAAACAATTACATGAGCAAGGGCAGTATCGCAATTTGCACGT
AACAGAACAAGCAGAAGAGACATGGCTTATTCGAGATGAGAAAAGGATGCTAAATTTAGCGTCAAATAATTATTTAGGAT
TAGCTGGAGATGAAAGGTTAAAAGAAGCTGCTATCGTATGCACAAGAAAATATGGAACTGGGGCGACAGCATCAAGGCTT
GTGGTAGGAAACTATTCACTGTATGAAGAGGTTGAGAGAAGTATATGCAATTGGAAAGGCACTGAAAAAGCCTTAGTTGT
AAATAGTGGATTTACCGCAAATGTTGGAGCGATTTCTTCATTAGCCTGTCGTCACGATATTGTTTTTAGCGATAAATTAA
ATCATGCGAGCATTGTTGATGGAATTATATTAAGCGGGGCAGAGCATAAAAGATATCGACATAATGATTTAAATCATCTG
GAGGCGTTGTTGAAAACAGCATCTCCTGAAAAGCGGAAATTAATCGTAACAGATACTGTTTTTAGTATGGATGGTGATAC
TGCGCATTTGAGGGAGTTAGTGCAGCTGAAAGAGAAATACGGGGCAATCATTATAGTTGATGAAGCACATGCGAGTGGAA
TATATGGAATTGGTGGAGCAGGGTTATCTCATATAGAAAAAGATCTTGCTCAAAAAATAGATATACATATGGGGACGTTT
AGCAAGGCTTTAGGGTGCTATGGTGCGTATTTGACAGGTGATGCAATTTATATAGAGTATTTGCAAAATATGATGAGAAG
CTTTATTTTTACTACAGCTTTACCGCCAAGTACGTTAGGAGCAGTGCAAAAAGCAATTGAAATTGTACAAGAAGATCATA
AGAGAAGAGAGAACCTTATAGCAAATGGAGAATACTTCAGGAGTAAATTACGAGAAGCTGGATTTAATATAGGGAATAGT
TCAACTCATATTGTACCGATTGTAGTTGGTTCAAATGAAAATACTTTACGGTTTAGCAAAAGGTTACAAGAGGCAGGTAT
TGCAGCTATTGCAATTCGTCCGCCCACTGTACCGGTCCATAGTTCTCGAATTCGCTTTGCAGTTACATCTCAACATACAA
TAGCTGATTTAAAATGGGCTATTGACCGAATTACCCACATTGCGAAAGAAGAGGAGCTTTTCGTATGA

Upstream 100 bases:

>100_bases
GGCTTATTACCATTCTTTGAAGGTGAGTTTACAAAAGAAGAAGTATTGGAATCTGCTAAAGAATATATAATGATTTCAAA
ATTAGAGGAGTTCATCCGAA

Downstream 100 bases:

>100_bases
AAGAGCTGAAAATCATTTTTATCCCTGGATGGGGAATGGAAGAAAATATTTGGGATTTAGTACTTCCACATTTTAAAGGA
TATTCTGTTCAATGCATTGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase 2; 7-keto-8-amino-pelargonic acid synthase 2; 7-KAP synthase 2; KAPA synthase 2; 8-amino-7-ketopelargonate synthase 2; Alpha-oxoamine synthase 2; L-alanine--pimeloyl-CoA ligase 2

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERLKEAAIVCTRKYGTGATASRL
VVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV

Sequences:

>Translated_395_residues
MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERLKEAAIVCTRKYGTGATASRL
VVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV
>Mature_395_residues
MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERLKEAAIVCTRKYGTGATASRL
VVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=33.6206896551724, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=33.6206896551724, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=32.0547945205479, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI119220554, Length=351, Percent_Identity=31.0541310541311, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI83977442, Length=336, Percent_Identity=33.9285714285714, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI83977444, Length=336, Percent_Identity=33.9285714285714, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI83977440, Length=336, Percent_Identity=33.9285714285714, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=32.0809248554913, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=32.0809248554913, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI5454084, Length=262, Percent_Identity=30.5343511450382, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=33.248730964467, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=32.5, Blast_Score=221, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=32.9081632653061, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=30.6451612903226, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=26.9021739130435, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=26.9021739130435, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982617, Length=285, Percent_Identity=25.2631578947368, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=285, Percent_Identity=25.2631578947368, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=28.3378746594005, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=29.9741602067183, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=29.9625468164794, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=33.7628865979381, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI17137420, Length=346, Percent_Identity=34.1040462427746, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=31.1653116531165, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24653280, Length=280, Percent_Identity=27.5, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24653276, Length=280, Percent_Identity=27.5, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24653278, Length=280, Percent_Identity=27.5, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB2_BACAN (Q81MB0)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846572.1
- RefSeq:   YP_020985.1
- RefSeq:   YP_030276.1
- HSSP:   P0AB77
- ProteinModelPortal:   Q81MB0
- SMR:   Q81MB0
- EnsemblBacteria:   EBBACT00000012697
- EnsemblBacteria:   EBBACT00000017658
- EnsemblBacteria:   EBBACT00000023418
- GeneID:   1087553
- GeneID:   2815754
- GeneID:   2849427
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_4339
- KEGG:   bar:GBAA_4339
- KEGG:   bat:BAS4026
- TIGR:   BA_4339
- TIGR:   GBAA_4339
- GeneTree:   EBGT00050000000589
- HOGENOM:   HBG649839
- OMA:   ASMGACM
- ProtClustDB:   PRK05958
- BioCyc:   BANT260799:BAS4026-MONOMER
- BioCyc:   BANT261594:GBAA4339-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 44073; Mature: 44073

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 23-23 BINDING 135-135 BINDING 182-182 BINDING 356-356

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERL
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECHHHHHHHCCCCEEECCCHHHH
KEAAIVCTRKYGTGATASRLVVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISS
HHHHHEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHH
LACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTV
HHHHHCEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
FSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
EECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVH
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCC
SSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQPWRTHLQTKLKQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLAGDERL
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECHHHHHHHCCCCEEECCCHHHH
KEAAIVCTRKYGTGATASRLVVGNYSLYEEVERSICNWKGTEKALVVNSGFTANVGAISS
HHHHHEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHH
LACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTV
HHHHHCEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
FSMDGDTAHLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
EECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVH
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCC
SSRIRFAVTSQHTIADLKWAIDRITHIAKEEELFV
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629