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The map label for this gene is trpC

Identifier: 49184178

GI number: 49184178

Start: 1206146

End: 1206907

Strand: Direct

Name: trpC

Synonym: BAS1159

Alternate gene names: 49184178

Gene position: 1206146-1206907 (Clockwise)

Preceding gene: 49184177

Following gene: 49184179

Centisome position: 23.07

GC content: 35.3

Gene sequence:

>762_bases
GTGGGGACGATTTTAGACAAAATTGTAAATCAAAAGAAAAAGGAAGTTGCGGCATTATATGAAACATATACACCAGTAAA
AGAAAAAAGAAAAACGCGCTCACTTGTAAAGGCTCTAGAGCAATTTACTGTCATCGCAGAAGTAAAGCGAGCATCACCAT
CAAAAGGAGATATTAATTTACACGTTGATGTACGAAAACAAGTGAAGACATATGAAGAATGCGGCGCTGGTGCAGTTTCT
GTTTTAACAGACGGTCAATTTTTTAAAGGGTCATTTTATGATTTACAAACGGCAAGAGAAGAAAGTAGCATTCCGCTTTT
ATGTAAAGATTTCATAATCGATAAGATTCAAATTGATAGAGCGTATGAAGCTGGTGCAGATATTATTTTACTAATCGTAG
CGGCGTTAACGAAAGAGAAATTAAAAGAGTTGTATAGCTACGTACTAGAAAAAGGATTAGAAGCGATTGTTGAAGTTCAT
GATGAACAGGAATTAGAAATTGCAATTCAATTAAATCCGCACGTTATCGGTATTAACAACCGTAATTTAAAAACATTCGA
AGTCGATTTAAGTCAAACAGAAAAGCTTGGAAAACGATTAAATGAGGAGAAATTACTTTGGATTAGTGAGAGCGGGATTC
ATTCAAAAGAAGACATAATCCGCGTTAAACGAGCTGGGGCAAAAGGTGTATTAGTTGGAGAAGCGCTTATGACATCGTCT
TCTATTCATACCTTTTTTGAAGATTGTAAGGTGAACATATGA

Upstream 100 bases:

>100_bases
ATAACACTCGCAGCACATAGCATTGACTCTGGAAAAGCATTAGCGAAACTAAACTTATTAATTGCAGCAAGTAACGAAGA
ATTAGAAAGGGTGAATTAAA

Downstream 100 bases:

>100_bases
AAGTGAAAATTTGCGGTATCACTGATATGGAAACAGCAAAACGTGCTTGCGAATACGGAGCTGATGCACTTGGATTTGTT
TTTGCAGAAAGTAAGCGGAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MGTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVS
VLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVH
DEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
SIHTFFEDCKVNI

Sequences:

>Translated_253_residues
MGTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVS
VLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVH
DEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
SIHTFFEDCKVNI
>Mature_252_residues
GTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVSV
LTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHD
EQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSS
IHTFFEDCKVNI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=253, Percent_Identity=36.7588932806324, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=43.6619718309859, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACAA (C3P3T8)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002865767.1
- ProteinModelPortal:   C3P3T8
- SMR:   C3P3T8
- EnsemblBacteria:   EBBACT00000125282
- GeneID:   7851405
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1327
- GeneTree:   EBGT00050000001798
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28437; Mature: 28306

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINL
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDR
EEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SIHTFFEDCKVNI
HHHHHHHHHCCCC
>Mature Secondary Structure 
GTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINL
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDR
EEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SIHTFFEDCKVNI
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA