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The map label for this gene is gabT [H]

Identifier: 49183338

GI number: 49183338

Start: 332247

End: 333611

Strand: Direct

Name: gabT [H]

Synonym: BAS0310

Alternate gene names: 49183338

Gene position: 332247-333611 (Clockwise)

Preceding gene: 49183337

Following gene: 49183339

Centisome position: 6.35

GC content: 39.27

Gene sequence:

>1365_bases
ATGAATACAAAAAAATTTGCTAAAGTAAATGAACAAATTCCTGGACCGAAAGCAGCGTCTTTACTAGAACGCCGCCAAAA
TATAGTACCAAAAGGAGTAAGTAACGGCATCCCAACGTTTGTACAATCTGCAAACGGTGCTCTTGTAACAGATGTTGATG
GCAATCAGTACATTGATTTCGCTGGAGCGATAGGAACAATTAACGTAGGGCATTGTCACCCAGCTGTTAAAGAAGCGCTC
CATAAACAAGTAGATCAATACATCCATACGGGCTTTAATGTCATGATGTATGAGCCATATATTGAATTAGCAGAAAAACT
TGCGGCATTAGCACCAGGAAGTTTTGATAAGCAAGTACTATTTTTAAATAGTGGTGCAGAAGCAGTTGAGAATGCGGTGA
AAATCGCTCGTAAATATACAAAAAGACCTGGCATTATCGCTTTTTCTAAAGGTTTCCACGGACGTACATTAATGACAATG
ACGATGACAAGTAAAGTAAAACCATATAAATTTGGATTTGGCCCATTTGCTCCAGAAGTATATAAAGCGCCATTCCCTTA
TGAATATCGTTGCCCAGAAGGATTAACGGAAGAGCAGTATGATGACTTTATGATTGAAGAGTTTAAGAATTTCTTCATAT
CAGAAGTAGCACCAGAAACGATTGCAGCCGTTGTAATGGAACCTGTTCAAGGGGAAGGTGGATTTATCGTCCCAAGTAAG
AAGTTTGCGCAAGAAGTACGCAATATTTGTTCAGAACACGGCATCTTATTTGTAGCGGATGAAATTCAAACAGGATTTAG
CCGTACAGGAAAATATTTTGCCATTGATCATTATGATGTCGTTCCGGATTTAATTACGGTATCTAAATCATTAGGTGCTG
GTGTACCAATTAGTGGTGTTATTGGGCGCAAGGAAATTATGAATGAGTCTGCACCAGGAGAGCTTGGGGGAACGTATGCG
GGAAGCCCGCTAGGATGTGCGGCAGCATTAGCAGTACTTGATGTAATAGAAAAAGAGAATTTAAATGATAGAGCGATAGA
ATTAGGAAAAGTTGTAATGAACCGATTCGAAGAGATGAAAAATAAATATAATTGCATCGGTGATGTGCGCGGTTTAGGAG
CAATGTGTGCATTCGAGCTCGTTCAAGACCGTAAGACGAAAACACCTGATAAAACGTTAACAGCTAATTTGTGCACAGAA
GCAAACAAACGCGGCCTACTTCTACTATCAGCAGGAACATACGGTAATGTTATTCGTGTACTAATGCCGCTAGTTATTAC
AGATGAGCAACTGGAAGAAGGATTAACAATTATTGAAGAATCATTGCAAATTTGTTATGAGAAAGCAAATACTGCCCGTG
TTTAA

Upstream 100 bases:

>100_bases
GCGAAATAGAAGGTGTGTAGGATGAATATTGGAAAAGAATGTTGGCATACATTTTGCAATAAAAAGAGAAAACAATGTAA
AGAAAAGGATGGGGTACGTA

Downstream 100 bases:

>100_bases
AAGTTAAATAAATAGCAAACATTCTAGCTGACTCTATATAAAATGCAGAAAATTCACTTTATAATAAAGGTAGTGAAGTG
AATCGATGGATTGGAAGTTA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEVAPETIAAVVMEPVQGEGGFIVPSK
KFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTANLCTE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV

Sequences:

>Translated_454_residues
MNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEVAPETIAAVVMEPVQGEGGFIVPSK
KFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTANLCTE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV
>Mature_454_residues
MNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEVAPETIAAVVMEPVQGEGGFIVPSK
KFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYA
GSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTANLCTE
ANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=35.3221957040573, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32.2352941176471, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=31.6784869976359, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI24119277, Length=424, Percent_Identity=31.6037735849057, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=32.1428571428571, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=36.0606060606061, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=30.9692671394799, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1789016, Length=430, Percent_Identity=47.4418604651163, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=47.8571428571429, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=34.0050377833753, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=34.0909090909091, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI145693181, Length=422, Percent_Identity=33.4123222748815, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=31.0144927536232, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=27.3584905660377, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=447, Percent_Identity=31.3199105145414, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=32.2195704057279, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=30.1204819277108, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=298, Percent_Identity=29.1946308724832, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=471, Percent_Identity=25.0530785562633, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=33.175355450237, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324432, Length=415, Percent_Identity=32.289156626506, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=431, Percent_Identity=25.5220417633411, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=449, Percent_Identity=24.9443207126949, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=31.7073170731707, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=32.4009324009324, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=32.3741007194245, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=32.0574162679426, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=26.3657957244656, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=26.3657957244656, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=26.3657957244656, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49708; Mature: 49708

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDF
CCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEECCCCCEEEE
AGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEVAPETIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC
IGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMK
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTANLCTEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLVITDEQLEEGLTIIEESLQICYEKANTARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQYIDF
CCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEECCCCCEEEE
AGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEVAPETIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC
IGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMK
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTANLCTEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLVITDEQLEEGLTIIEESLQICYEKANTARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]