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The map label for this gene is map [H]

Identifier: 49183166

GI number: 49183166

Start: 132148

End: 132894

Strand: Direct

Name: map [H]

Synonym: BAS0132

Alternate gene names: 49183166

Gene position: 132148-132894 (Clockwise)

Preceding gene: 49183165

Following gene: 49183167

Centisome position: 2.53

GC content: 42.84

Gene sequence:

>747_bases
ATGATAATCTGCAAAACTCCTCGCGAGATAGAAATCATGCGAGAAGCTGGCAGGATCGTTGCTTTAACTCATCAAGAGTT
AAAACAACACATTACTCCAGGAATTACAACGAAAGAGCTCGATCAAATAGCGGAAAAGACGATTCAAAAATATGGTGCTA
CGCCATCTTTTAAAGGATACAACGGATTTCCGGGGAGCATATGTGCTTCTGTAAATGAAGAGCTTGTACACGGAATTCCA
GGGAAGCGCAAGCTCAAAGAGGGCGATATCATCAGTATCGATATTGGTGCGAAATACAATGGGTACCATGGAGATTCTGC
ATGGACGTATCCAGTTGGAAACATTTCTGAATCTGTTCAAAAGCTACTTGATGTCACAGAAAAATCGTTGTATCTTGGTC
TAGAACAAGTAAAACCAGGCGAGAGATTATCAAATATCTCACATGCGGTTCAAACCCATGCTGAAGAGAATGGATTCTCG
ATCGTTAGGGAGTATGTTGGTCACGGAATCGGGCAAGACTTACATGAGGACCCTCAAATCCCGCACTATGGTCCACCAAA
TAGAGGCCCTAGATTAAAGCCGGGAATGGTCATCTGTGTTGAGCCGATGGTGAATCAAGGAAGACGATATGTAAAAACAC
TATCTGATGACTGGACAGTGGTAACGGTAGATGGTAAATGGTGTGCCCATTTTGAGCACACGATTGCTCTTACAGAAGCA
GGATACGAAATCCTTACCACTTTATAA

Upstream 100 bases:

>100_bases
ATTTCTACGAGGAGCTTGGTTACCTACAAAGCATTAATGGTGAGCAAGATATCAATAAAGTATTTGCTGATATCGATGTT
CTCATCGGAGGCTTAGCGTA

Downstream 100 bases:

>100_bases
GTAGCTGGCTCTCCGGGATTTCAGAGCAGTGTAAAATGTTACTGATTTGATGAAGGGAGAACTATTGAATGGCTAAAGAT
GATGTAATTGAAGTCGAAGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEDPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL

Sequences:

>Translated_248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEDPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL
>Mature_248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEDPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=238, Percent_Identity=41.5966386554622, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI40385867, Length=214, Percent_Identity=40.6542056074766, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786364, Length=244, Percent_Identity=44.672131147541, Blast_Score=220, Evalue=8e-59,
Organism=Escherichia coli, GI1789275, Length=222, Percent_Identity=26.5765765765766, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788728, Length=204, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=242, Percent_Identity=39.2561983471074, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=219, Percent_Identity=47.4885844748858, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21355531, Length=238, Percent_Identity=41.5966386554622, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=38.6831275720165, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19920384, Length=231, Percent_Identity=23.3766233766234, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27527; Mature: 27527

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGY
CEEECCCHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGFPGSICASVNEELVHGIPGKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQ
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHH
KLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFSIVREYVGHGIGQDLHEDPQI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCCCC
PHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
CCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCEEEEEECCCEEECHHHEEEEHHC
GYEILTTL
CHHHHHCC
>Mature Secondary Structure
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGY
CEEECCCHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGFPGSICASVNEELVHGIPGKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQ
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHH
KLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFSIVREYVGHGIGQDLHEDPQI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCCCC
PHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
CCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCEEEEEECCCEEECHHHEEEEHHC
GYEILTTL
CHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]