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The map label for this gene is adk

Identifier: 49183165

GI number: 49183165

Start: 131498

End: 132148

Strand: Direct

Name: adk

Synonym: BAS0131

Alternate gene names: 49183165

Gene position: 131498-132148 (Clockwise)

Preceding gene: 49183164

Following gene: 49183166

Centisome position: 2.51

GC content: 39.63

Gene sequence:

>651_bases
ATGAACTTAATTTTAATGGGGCTTCCTGGTGCTGGTAAAGGTACACAAGCCGAACAGATTGTTGCCAAGTATAACATCCC
TCACATCTCAACAGGAGATATGTTCCGTGCAGCTATGAAGGCTGAAACTGAAATGGGTTTACAAGCAAAATCTTTTATTG
ATAAAGGTGCACTTGTTCCAGATGAAGTTACAATCGGAATTGTTCGTGAACGTTTAAGCCAAGAAGACTGTGTAAGAGGC
TTCTTATTAGATGGTTTCCCACGAACTGTTGCACAAGCATCAGCTCTTGAAGAGATTATGAAAGATCTTGGCAAAAAAAT
CGACTATGTTTTAAACATTAATGTGGATTCAGGGTTGTTATTAAAACGCCTTACAGGCCGTCGCATTTGTAAAGAGTGCG
GTGCGACTTACCACTTAGAATTCAATGCGCCAGCAAAAGCTGACGTGTGCGATAAATGTGGTGGCGAATTATATCAACGC
TCTGATGACAATGAAGAAACTGTAGCAAATCGCTTAGATGTAAATATTAAGCAAACTAAACCTTTGCTTGATTTCTACGA
GGAGCTTGGTTACCTACAAAGCATTAATGGTGAGCAAGATATCAATAAAGTATTTGCTGATATCGATGTTCTCATCGGAG
GCTTAGCGTAA

Upstream 100 bases:

>100_bases
GCCAACTGGTAAAACGCCATTACAAAGGGTTTATCAAGCAGTGAGTAAGTGGGAAGTATTGTCTTCCCTACATGCTCATG
TACTCTGAGGGGGAACAAGG

Downstream 100 bases:

>100_bases
TGATAATCTGCAAAACTCCTCGCGAGATAGAAATCATGCGAGAAGCTGGCAGGATCGTTGCTTTAACTCATCAAGAGTTA
AAACAACACATTACTCCAGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Sequences:

>Translated_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
>Mature_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQR
SDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=40.9756097560976, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=40.9756097560976, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI19923437, Length=208, Percent_Identity=39.4230769230769, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=36.2790697674419, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=36.2790697674419, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=36.2790697674419, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=36.2790697674419, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=32.5358851674641, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=30.2884615384615, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=27.9620853080569, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=29.5238095238095, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=29.5238095238095, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=47.2477064220183, Blast_Score=195, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=39.7129186602871, Blast_Score=161, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=33.495145631068, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=30.6930693069307, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.4038461538462, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=40, Blast_Score=174, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=35.3535353535354, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=211, Percent_Identity=27.9620853080569, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=40.0943396226415, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=35.2040816326531, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=35.2040816326531, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=26.5700483091787, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=26.5700483091787, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BACAA (C3P9S6)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864782.1
- ProteinModelPortal:   C3P9S6
- SMR:   C3P9S6
- EnsemblBacteria:   EBBACT00000128983
- GeneID:   7850890
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0147
- GeneTree:   EBGT00050000002446
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23744; Mature: 23744

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHCCCHHHCC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNAPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHCCCHHHCC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA