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The map label for this gene is lpxK [H]

Identifier: 46447420

GI number: 46447420

Start: 2141506

End: 2142612

Strand: Reverse

Name: lpxK [H]

Synonym: pc1786

Alternate gene names: 46447420

Gene position: 2142612-2141506 (Counterclockwise)

Preceding gene: 46447421

Following gene: 46447419

Centisome position: 88.74

GC content: 36.4

Gene sequence:

>1107_bases
ATGTTTTTGAGAAAAATTGAAATTTATCTCAAGGAAATCATTAAAGAAAAACGAAAAGGAAAATTATCTACATTTATTAA
ATGGATACTTTTACCGTTGAGTTGGATTTATGGTTTTATTGTGTCTATTCGAAATTGGCTTTATGATCAAGGATGGATGA
AAAGATACGTTCCTCCCGTCTCTTTGGTCATCAGTATTGGCAATATCGTCGCTGGCGGAACAGGTAAAACTCCGGTCACT
CTTCTTCTTGCTCAAGCTTTTTATGAACGTTACACATTAGCTATTTTATCTCGAGGGTATCGATCGAAAGTAGAAAAATT
AGAAACCCCAGTTATCCTTTGTGAGGGGCAGGGACCAATTTTTCCTGCTTCTTATTCCGGAGATGAACCTTATATTTACG
CTCAACGTTTTCCCAAATCGATTGTGATTGTTGGAAGGAACCGTAAAAAAGCATCTTTTTTAGCAGCCAAAGCTGGAGCT
CAAGTTATTTTATTAGACGATGCTATGCAACACCGTCGCATTGCTAGGGATTATGATGTTGTCGTGATAGATGTTTCAGA
TCCTTTTGGCCGAGGTTATTATCTACCAAGAGGATTTTTAAGAGAGGATGTCCACTCTTTATCTCGGGCCGATTTATTAA
TTTTAAACAATATTGTTGATGCAGAACAGTTTGAGAATGTAAAAAATCAGCTTAGAGCTTATAGTTTAGCTCCAATAGTA
GGGGTCAAAGGAATAGTCTGCCATCCAAGGGATTTAAAGGGATGCCAAATAGACAACTTACATGAAACTAAAGTGGCTAT
GTTTTGTGCGATTGCTCATCCAGAATATTTTAAGCGCACCTTAGAGTCTGAGGGAATAAAAGTTGTTTCAGAATTTTGTT
TACCTGATCACGATGAGATTAAAGAGAGAAAATTAGAATTATTTGCTTTACAATCTAAAGAGTTAGGGGCTGAGTGGTTG
ATTTGTACGGAGAAAGATCGTGTAAAATTACCAGATCAAATGACTTTAAGTTTACCAATTGCTTGGATTCAAATCGATTT
AACAGTTATCGATGGGCAAAACGAATGGAATTCCTTTCTTGCACAGGCTGAAGCTAAAATTTCTTAA

Upstream 100 bases:

>100_bases
TGCATTTATTTGCAAAAAATTAAATTTTATCAAATGTTAATGATTGGGAGTTTTTAAAATTTTATCATTCATTTTTATCG
AGCTTAATAAGGTTTTTTGC

Downstream 100 bases:

>100_bases
AAATCTTTCGCTATTTCAAATTGTTTAATGACGAGGCATGAATTAAAAGTATGAAGTTGTGGCTGAAAATTTTCATTGGT
TTGGCGTTAGGTGTTTTAGC

Product: putative tetraacyldisaccharide (lipid A) 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MFLRKIEIYLKEIIKEKRKGKLSTFIKWILLPLSWIYGFIVSIRNWLYDQGWMKRYVPPVSLVISIGNIVAGGTGKTPVT
LLLAQAFYERYTLAILSRGYRSKVEKLETPVILCEGQGPIFPASYSGDEPYIYAQRFPKSIVIVGRNRKKASFLAAKAGA
QVILLDDAMQHRRIARDYDVVVIDVSDPFGRGYYLPRGFLREDVHSLSRADLLILNNIVDAEQFENVKNQLRAYSLAPIV
GVKGIVCHPRDLKGCQIDNLHETKVAMFCAIAHPEYFKRTLESEGIKVVSEFCLPDHDEIKERKLELFALQSKELGAEWL
ICTEKDRVKLPDQMTLSLPIAWIQIDLTVIDGQNEWNSFLAQAEAKIS

Sequences:

>Translated_368_residues
MFLRKIEIYLKEIIKEKRKGKLSTFIKWILLPLSWIYGFIVSIRNWLYDQGWMKRYVPPVSLVISIGNIVAGGTGKTPVT
LLLAQAFYERYTLAILSRGYRSKVEKLETPVILCEGQGPIFPASYSGDEPYIYAQRFPKSIVIVGRNRKKASFLAAKAGA
QVILLDDAMQHRRIARDYDVVVIDVSDPFGRGYYLPRGFLREDVHSLSRADLLILNNIVDAEQFENVKNQLRAYSLAPIV
GVKGIVCHPRDLKGCQIDNLHETKVAMFCAIAHPEYFKRTLESEGIKVVSEFCLPDHDEIKERKLELFALQSKELGAEWL
ICTEKDRVKLPDQMTLSLPIAWIQIDLTVIDGQNEWNSFLAQAEAKIS
>Mature_368_residues
MFLRKIEIYLKEIIKEKRKGKLSTFIKWILLPLSWIYGFIVSIRNWLYDQGWMKRYVPPVSLVISIGNIVAGGTGKTPVT
LLLAQAFYERYTLAILSRGYRSKVEKLETPVILCEGQGPIFPASYSGDEPYIYAQRFPKSIVIVGRNRKKASFLAAKAGA
QVILLDDAMQHRRIARDYDVVVIDVSDPFGRGYYLPRGFLREDVHSLSRADLLILNNIVDAEQFENVKNQLRAYSLAPIV
GVKGIVCHPRDLKGCQIDNLHETKVAMFCAIAHPEYFKRTLESEGIKVVSEFCLPDHDEIKERKLELFALQSKELGAEWL
ICTEKDRVKLPDQMTLSLPIAWIQIDLTVIDGQNEWNSFLAQAEAKIS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=303, Percent_Identity=32.6732673267327, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 41951; Mature: 41951

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLRKIEIYLKEIIKEKRKGKLSTFIKWILLPLSWIYGFIVSIRNWLYDQGWMKRYVPPV
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
SLVISIGNIVAGGTGKTPVTLLLAQAFYERYTLAILSRGYRSKVEKLETPVILCEGQGPI
HHEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
FPASYSGDEPYIYAQRFPKSIVIVGRNRKKASFLAAKAGAQVILLDDAMQHRRIARDYDV
CCCCCCCCCCEEEHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEECCHHHHHHHCCCCCE
VVIDVSDPFGRGYYLPRGFLREDVHSLSRADLLILNNIVDAEQFENVKNQLRAYSLAPIV
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHHHHHHCCHHH
GVKGIVCHPRDLKGCQIDNLHETKVAMFCAIAHPEYFKRTLESEGIKVVSEFCLPDHDEI
CCCCEEECCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
KERKLELFALQSKELGAEWLICTEKDRVKLPDQMTLSLPIAWIQIDLTVIDGQNEWNSFL
HHHHHHHEEECCHHCCCEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCHHHHHH
AQAEAKIS
HHHHHCCC
>Mature Secondary Structure
MFLRKIEIYLKEIIKEKRKGKLSTFIKWILLPLSWIYGFIVSIRNWLYDQGWMKRYVPPV
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
SLVISIGNIVAGGTGKTPVTLLLAQAFYERYTLAILSRGYRSKVEKLETPVILCEGQGPI
HHEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
FPASYSGDEPYIYAQRFPKSIVIVGRNRKKASFLAAKAGAQVILLDDAMQHRRIARDYDV
CCCCCCCCCCEEEHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEECCHHHHHHHCCCCCE
VVIDVSDPFGRGYYLPRGFLREDVHSLSRADLLILNNIVDAEQFENVKNQLRAYSLAPIV
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHHHHHHCCHHH
GVKGIVCHPRDLKGCQIDNLHETKVAMFCAIAHPEYFKRTLESEGIKVVSEFCLPDHDEI
CCCCEEECCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
KERKLELFALQSKELGAEWLICTEKDRVKLPDQMTLSLPIAWIQIDLTVIDGQNEWNSFL
HHHHHHHEEECCHHCCCEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCHHHHHH
AQAEAKIS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA