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The map label for this gene is gltT [H]

Identifier: 46447419

GI number: 46447419

Start: 2140226

End: 2141455

Strand: Reverse

Name: gltT [H]

Synonym: pc1785

Alternate gene names: 46447419

Gene position: 2141455-2140226 (Counterclockwise)

Preceding gene: 46447420

Following gene: 46447418

Centisome position: 88.69

GC content: 37.32

Gene sequence:

>1230_bases
ATGAAGTTGTGGCTGAAAATTTTCATTGGTTTGGCGTTAGGTGTTTTAGCAGGAATTATTTTGGGAGAAAGGGCTGCTTT
ATTAAAGCCTTTAGGAACTATTTTTCTCAATTTGATCAACATGATTATTCCTTTGTTGATTCTCTCTTCAATGGCTATAG
GAATCACAAGTATTCACGATCCTCAAAAATTAGGGCGCGTGGGGGGTAAAACGATTGGGATTTATTTCATTACAACAGTC
ATTTCTATTTTAATCGGTATATTATTTGCTAATTCTTTTCAAGTTGGTTCAGGCCTTCATTTAACATCTGTCAATATCAT
AGAAGCAAAAACTCCTTCTTTTAGTGAAATTATTGTCTCAATTATTCCGAGCAATCCAGTTGCTGCTTTAGCGAGTGGGA
GTATTTTGCAAATCATTGTTTTTGCAGTTTTTTTAGGAATTGCAATTAATTTTTCTGGAGAAAAGGGAATTCCTTTAAAA
AACTTTTTAGAATCTTTAGCTGATGTCATGTACCGTTTAACTTCATTAGTGATGGAATTTTCTCCGATTGGAGTTTTTGG
CATCATGGCTTGGGTCGCTGGGACGTTTGGTATTTCTTTATTGATCCCTTTGTTTAAATTTTTAGGCGTTTATTATTTAG
CTTGTCTCATTCATTTGGCAGTTGTTTACAGCCTTATTTTATTAAAAGGATTAGGACATTTGCAGATTTTACCTTTTTTT
AAAGGAATGGGTGACGCCATTATGATGGCTTTTTCAACAGGAAGTAGCGCAGCAACTTTACCTGTGGCCATGCACTGTTT
ACAAGAGAACTTAGGTGTTTCAAAAAATATTTCAAATTTTGTCCTTCCTCTTGGCTTGACAATGAATATGAACGGTTCAG
CTATCTTTCAAGCCATGAGTGCTATATTTATTGCAAAAGCCTATGCGATCCCATTAGACCTATCTGCTTACATTACACTT
TTAATGACAGCAACCATGGCTGCCATCGGGACCGCTGGGGTTCCTGGAGGCGGATTTGTGATGCTCTCGGCGGTCCTTAC
TTCACTAGGACTTCCTTTAGAAGGTTTAGCTGTTTTAGTGGGTATCGATCGGTTACGAGAAATGGTTACCACAGTATTGA
ATATTTTAGGCGATGCTGCAGTGACAGTGTTTATTGCTAAGCAAGAGGGCGAGTTGGACGAACGTAAATATTACCATACT
GAACTTGTCGAATTCGAAGGGAAAATCTAA

Upstream 100 bases:

>100_bases
AAAACGAATGGAATTCCTTTCTTGCACAGGCTGAAGCTAAAATTTCTTAAAAATCTTTCGCTATTTCAAATTGTTTAATG
ACGAGGCATGAATTAAAAGT

Downstream 100 bases:

>100_bases
TTTATGCTTTATTTATAGATTAGGTATAAAGATCATAGAATATGTCAGAGTCTACAAAAATGAATTGGTTATCAAAAGAT
TTTATTCAATATGATAAAGG

Product: putative proton/sodium-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKLWLKIFIGLALGVLAGIILGERAALLKPLGTIFLNLINMIIPLLILSSMAIGITSIHDPQKLGRVGGKTIGIYFITTV
ISILIGILFANSFQVGSGLHLTSVNIIEAKTPSFSEIIVSIIPSNPVAALASGSILQIIVFAVFLGIAINFSGEKGIPLK
NFLESLADVMYRLTSLVMEFSPIGVFGIMAWVAGTFGISLLIPLFKFLGVYYLACLIHLAVVYSLILLKGLGHLQILPFF
KGMGDAIMMAFSTGSSAATLPVAMHCLQENLGVSKNISNFVLPLGLTMNMNGSAIFQAMSAIFIAKAYAIPLDLSAYITL
LMTATMAAIGTAGVPGGGFVMLSAVLTSLGLPLEGLAVLVGIDRLREMVTTVLNILGDAAVTVFIAKQEGELDERKYYHT
ELVEFEGKI

Sequences:

>Translated_409_residues
MKLWLKIFIGLALGVLAGIILGERAALLKPLGTIFLNLINMIIPLLILSSMAIGITSIHDPQKLGRVGGKTIGIYFITTV
ISILIGILFANSFQVGSGLHLTSVNIIEAKTPSFSEIIVSIIPSNPVAALASGSILQIIVFAVFLGIAINFSGEKGIPLK
NFLESLADVMYRLTSLVMEFSPIGVFGIMAWVAGTFGISLLIPLFKFLGVYYLACLIHLAVVYSLILLKGLGHLQILPFF
KGMGDAIMMAFSTGSSAATLPVAMHCLQENLGVSKNISNFVLPLGLTMNMNGSAIFQAMSAIFIAKAYAIPLDLSAYITL
LMTATMAAIGTAGVPGGGFVMLSAVLTSLGLPLEGLAVLVGIDRLREMVTTVLNILGDAAVTVFIAKQEGELDERKYYHT
ELVEFEGKI
>Mature_409_residues
MKLWLKIFIGLALGVLAGIILGERAALLKPLGTIFLNLINMIIPLLILSSMAIGITSIHDPQKLGRVGGKTIGIYFITTV
ISILIGILFANSFQVGSGLHLTSVNIIEAKTPSFSEIIVSIIPSNPVAALASGSILQIIVFAVFLGIAINFSGEKGIPLK
NFLESLADVMYRLTSLVMEFSPIGVFGIMAWVAGTFGISLLIPLFKFLGVYYLACLIHLAVVYSLILLKGLGHLQILPFF
KGMGDAIMMAFSTGSSAATLPVAMHCLQENLGVSKNISNFVLPLGLTMNMNGSAIFQAMSAIFIAKAYAIPLDLSAYITL
LMTATMAAIGTAGVPGGGFVMLSAVLTSLGLPLEGLAVLVGIDRLREMVTTVLNILGDAAVTVFIAKQEGELDERKYYHT
ELVEFEGKI

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=290, Percent_Identity=35.8620689655172, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI66773030, Length=448, Percent_Identity=29.9107142857143, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI21314632, Length=394, Percent_Identity=31.2182741116751, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI223468566, Length=264, Percent_Identity=38.2575757575758, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5032093, Length=411, Percent_Identity=31.1435523114355, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI223468564, Length=258, Percent_Identity=38.3720930232558, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI40254478, Length=441, Percent_Identity=26.7573696145125, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI169790839, Length=263, Percent_Identity=34.2205323193916, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI194239697, Length=258, Percent_Identity=35.6589147286822, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI301601644, Length=164, Percent_Identity=40.8536585365854, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI262359914, Length=204, Percent_Identity=32.3529411764706, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=34.688995215311, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=32.1782178217822, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1788024, Length=409, Percent_Identity=29.3398533007335, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1789473, Length=376, Percent_Identity=28.1914893617021, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=429, Percent_Identity=29.3706293706294, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71983099, Length=429, Percent_Identity=29.3706293706294, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71996953, Length=454, Percent_Identity=27.9735682819383, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193206505, Length=449, Percent_Identity=30.0668151447661, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=29.4258373205742, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=398, Percent_Identity=29.1457286432161, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=429, Percent_Identity=27.7389277389277, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24583025, Length=407, Percent_Identity=28.009828009828, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17137668, Length=407, Percent_Identity=28.009828009828, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24583023, Length=407, Percent_Identity=28.009828009828, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360483, Length=263, Percent_Identity=30.4182509505703, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17137666, Length=263, Percent_Identity=30.4182509505703, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281360481, Length=263, Percent_Identity=30.4182509505703, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43456; Mature: 43456

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWLKIFIGLALGVLAGIILGERAALLKPLGTIFLNLINMIIPLLILSSMAIGITSIHD
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQKLGRVGGKTIGIYFITTVISILIGILFANSFQVGSGLHLTSVNIIEAKTPSFSEIIVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHHH
IIPSNPVAALASGSILQIIVFAVFLGIAINFSGEKGIPLKNFLESLADVMYRLTSLVMEF
HCCCCCHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SPIGVFGIMAWVAGTFGISLLIPLFKFLGVYYLACLIHLAVVYSLILLKGLGHLQILPFF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHH
KGMGDAIMMAFSTGSSAATLPVAMHCLQENLGVSKNISNFVLPLGLTMNMNGSAIFQAMS
HCCCHHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHEEECCEEECCCHHHHHHHHH
AIFIAKAYAIPLDLSAYITLLMTATMAAIGTAGVPGGGFVMLSAVLTSLGLPLEGLAVLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GIDRLREMVTTVLNILGDAAVTVFIAKQEGELDERKYYHTELVEFEGKI
HHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLWLKIFIGLALGVLAGIILGERAALLKPLGTIFLNLINMIIPLLILSSMAIGITSIHD
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQKLGRVGGKTIGIYFITTVISILIGILFANSFQVGSGLHLTSVNIIEAKTPSFSEIIVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHHH
IIPSNPVAALASGSILQIIVFAVFLGIAINFSGEKGIPLKNFLESLADVMYRLTSLVMEF
HCCCCCHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SPIGVFGIMAWVAGTFGISLLIPLFKFLGVYYLACLIHLAVVYSLILLKGLGHLQILPFF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHH
KGMGDAIMMAFSTGSSAATLPVAMHCLQENLGVSKNISNFVLPLGLTMNMNGSAIFQAMS
HCCCHHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHEEECCEEECCCHHHHHHHHH
AIFIAKAYAIPLDLSAYITLLMTATMAAIGTAGVPGGGFVMLSAVLTSLGLPLEGLAVLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GIDRLREMVTTVLNILGDAAVTVFIAKQEGELDERKYYHTELVEFEGKI
HHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]